Exercise therapy for people with axial spondyloarthritis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the effects of a 12-week structured home-based aerobic exercise program on individuals with axial spondyloarthritis who are already receiving biologic therapy. The study aims to determine if brisk walking can improve quality of life, reduce symptoms, and lower markers of immune-mediated inflammation. Additionally, it will assess the acceptability of the intervention through participant feedback and evaluate its impact on cardiometabolic health and body composition. The trial will involve 40 participants, with half receiving the exercise intervention and the other half continuing routine care.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Diagnosis of axSpA by a consultant rheumatologist
* Age=/\>18 years old
* Without other significant cardiovascular comorbidities
* Receiving stable dose biologic treatment
* Able to commit to the time demands of the study

Exclusion Criteria:

* Unable to undertake exercise due to physical or psychological barriers
* Presence of hip or peripheral joint disease
* Contraindication to exercise training (American College of Sports Medicine guidelines)
* Excessively active (score of high on IPAQ)
* Unable to communicate sufficiently in English
* Female participants who are pregnant, lactating, or planning pregnancy during the course of the study.
* Inability to give informed consent or comply with testing and training protocol for any reason.
* Presence of chronic anaemia (haemoglobin less than 13.5 g/dL for men; less than 12.0 g/dL for women; or haematocrit less than 41.0% in men, less than 36.0% in women.
* Co-morbidity that the research team determine to be a contraindication to involvement

Inclusion and exclusion criteria of healthy controls:

Inclusion Criteria:

* Aged between 18 years old and 65 years old
* Not taking any long-term medication that affects inflammation or immune-mediated inflammation.
* Free from infection or infection symptoms

Exclusion criteria:

The participant may not enter the study if ANY of the following apply:

* Unable to undertake exercise due to physical or psychological barriers
* Excessively active (score of high on IPAQ)
* Unable to communicate sufficiently in English
* Female participants who are pregnant, lactating, or planning pregnancy during the course of the study.
* Inability to give informed consent or comply with testing and training protocol for any reason.
* Have been diagnosed with or are aware of at least one of the following health issues:
* Immune system disorder
* Cardiovascular and/or cardiometabolic diseases, including but not limited to high blood pressure, high triglycerides and/or cholesterol levels, diabetes mellitus, etc.
* Any chronic health condition that affects one's ability to partake in physical activity
* Musculoskeletal injury that affects one's ability to partake in physical activity

Where it's running

• Loughborough University, National Centre for Sport and Exercise Medicine
  Loughborough, Leicestershire, United Kingdom Recruiting
• University Hospitals of Leicester NHS trust
  Leicester, United Kingdom, United Kingdom Recruiting

Study contacts

• Principal investigator: Arumugam Moorthy, Dr — University Hospitals, Leicester
• Study coordinator: Nicolette C Bishop, PhD
• Email: N.C.Bishop@lboro.ac.uk
• Phone: 01509226385

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.