PROACTIVE: Tailored pain relief for musculoskeletal and arthritis-related movement pain

Testing the Pain Relief of musculOskeletal conditions and Arthritis using Carefully Tailored InterVEntions (PROACTIVE) Intervention: A Randomized Controlled Trial

NIH-funded research University of Florida · NIH-11369050

A tailored pain self-management program offering education, a resource toolkit, active prayer, and financial counseling for adults with chronic movement-related musculoskeletal pain.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionUniversity of Florida NIH-funded
Lab location1 site (Gainesville, United States)
Project IDNIH-11369050 on NIH RePORTER

What this research studies

You would be randomly assigned to either the PROACTIVE program or usual care and followed over time to see whether the program reduces pain when you move (movement-evoked pain). The PROACTIVE program combines focused pain self-management education, a practical toolkit of resources, an optional active prayer/spirituality component, and financial counseling about healthcare benefits. Researchers will measure movement-evoked pain, physical function, and other health factors such as health literacy and financial hardship to judge benefit. The intervention is designed to give older adults non-drug tools to manage pain and address real-life barriers to care.

Who could benefit from this research

Good fit: Adults aged 21 and older with chronic musculoskeletal pain that worsens with movement who are willing to try non-drug self-management approaches would be ideal candidates.

Not a fit: People with recent acute injuries needing immediate medical or surgical care, those requiring urgent opioid therapy, or those unable or unwilling to participate in self-management or spiritual components may not benefit.

Why it matters

Potential benefit: If successful, this program could reduce movement-related pain, improve mobility and daily functioning, and decrease reliance on long-term opioid or NSAID use.

How similar studies have performed: Prior pain self-management programs have shown mixed or small benefits and rarely focused primarily on movement-evoked pain, so combining tailored education with spirituality and financial counseling is a relatively new approach.

Where this research is happening

Gainesville, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.