Collection of synovial fluid from arthritis patients
Establishment of a Bank of Synovial Fluids and Paired Sera From Arthritic Patients for the Evaluation of New Methods Facilitating the Diagnosis and the Monitoring of Progression and Therapy of Arthritis.
This study is collecting joint fluid and blood samples from arthritis patients to see if new markers can help us understand joint damage and inflammation better.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 500 (estimated) |
| Ages | 3 Years to 95 Years |
| Sex | All |
| Sponsor | Université de Sherbrooke Academic / other |
| Locations | 1 site (Sherbrooke, Quebec) |
| Trial ID | NCT00512343 on ClinicalTrials.gov |
What this trial studies
This project aims to collect synovial fluid and paired serum samples from patients with arthritis to evaluate novel biomarkers related to joint damage and inflammation. The study will focus on understanding the prevalence and diagnostic/prognostic values of these biomarkers, as well as how therapeutic interventions may influence their levels. Specific attention will be given to biomarkers associated with bone resorption, cartilage degradation, and the activity of proteases involved in joint damage. The findings could lead to the identification of new therapeutic targets for arthritis treatment.
Who should consider this trial
Good fit: Ideal candidates for this study are arthritis patients with significant joint effusion.
Not a fit: Patients with hemorrhagic or traumatic effusions, or those unable to provide consent, may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved diagnostic tools and targeted therapies for arthritis patients.
How similar studies have performed: Other studies have shown promise in identifying biomarkers for arthritis, suggesting that this approach could yield valuable insights.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Significant joint effusion Exclusion Criteria: * Hemorrhagic effusion * Traumatic effusion * Less than 3 ml total of collected fluid (used for routine analysis and culture) * Inability or refusal to consent
Where this trial is running
Sherbrooke, Quebec
- Centre hospitalier universitaire de Sherbrooke — Sherbrooke, Quebec, Canada (Recruiting)
Study contacts
- Principal investigator: Gilles Boire, MD, MSc — CHUS and Université de Sherbrooke
- Study coordinator: Gilles Boire, MD, MSc
- Email: Gilles.Boire@USherbrooke.ca
- Phone: (819) 564-5261
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.