Understanding how T cells make IFN-γ and IL-17 in kids with juvenile arthritis

Who could benefit from this research

What this research studies

This grant focuses on how specific T cells (Th1 and Th17) and their inflammatory signals (IFN-γ and IL-17) develop in juvenile idiopathic arthritis. The work includes studying genetic mutations in JIA patients and how these mutations affect the production of IL-17 and IFN-γ, potentially identifying new targets for therapy. The research combines laboratory experiments with training for the investigator to advance translational skills that could benefit children with JIA. By identifying biologic factors that influence disease pathways, the project aims to inform better diagnostic and treatment decisions for young patients. The plan emphasizes a pathway from basic biology to clinically relevant insights that could guide future trials and care.

Why it matters

Where this research is happening

• Vanderbilt University Medical Center
  Nashville, United States Active

Researchers

• Principal investigator: Patrick, Anna Elizabeth — Vanderbilt University Medical Center
• Study coordinator: Patrick, Anna Elizabeth

Related research

Other NIH-funded projects on the same topics.

• Deciphering What Drives Juvenile Idiopathic Arthritis in African American Children

  This project looks at why African American children with juvenile idiopathic arthritis have more joint damage, using clinical data and genetic information to find factors that may explain the differences.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11442239

• Lung disease linked to systemic juvenile idiopathic arthritis in children

  This project looks at how ongoing immune activation and some arthritis medicines may cause lung inflammation and breathing problems in children with systemic juvenile idiopathic arthritis (SJIA).

  NIH research Cincinnati Childrens Hosp Med Ctr · Cincinnati, United States · NIH-11326213

• Linking JIA Registry with Claims Data to Improve Understanding of Juvenile Arthritis

  A study will connect the CARRA JIA patient registry with a large national claims database to see how well registry data match real-world care and outcomes for children with juvenile idiopathic arthritis.

  NIH research Rutgers Biomedical and Health Sciences · Newark, UNITED STATES · NIH-11295916

• Investigating the role of viruses and gut bacteria in arthritis flares in children

  This study is looking at how certain viruses and bacteria in the gut might affect flare-ups of juvenile idiopathic arthritis in kids, hoping to find clues that could help manage these painful episodes better.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11056288

• Understanding lung disease in children with systemic juvenile idiopathic arthritis

  This study is looking at how a serious lung problem in some kids with systemic juvenile idiopathic arthritis happens, and it aims to find new ways to help treat or prevent this issue by understanding how a certain part of their immune system works.

  NIH research Cincinnati Childrens Hosp Med Ctr · Cincinnati, United States · NIH-11042812

• Understanding how immune cells produce inflammatory signals in children with arthritis

  This study is looking at how certain immune cells in children with juvenile idiopathic arthritis produce substances that cause inflammation, and it hopes to find genetic clues that could help improve how we diagnose and treat this condition.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-10903950

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.