Understanding pain in inflammatory joint diseases
Official title: Advancing the Understanding of Pain Mechanisms in Inflammatory Arthritis Towards Precision Pain Management
Run by Diakonhjemmet Hospital · NCT06718569 · Data updated 2026-11-12
This project will follow people with inflammatory joint diseases who are starting or switching biological or targeted synthetic DMARDs to try to identify different pain types and see if central sensitization and cognitive function relate to persistent pain.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 350 (estimated) |
| Sponsor | Diakonhjemmet Hospital Academic / other |
| Locations | 1 site (Oslo) |
| Status | Recruiting |
| Started | November 11, 2025 |
| Main results expected | November 2027 |
| Study ends | November 2027 |
| Registry record updated | April 13, 2026 |
| Trial ID | NCT06718569 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
People with inflammatory joint diseases who are initiating or switching biological or targeted synthetic DMARD therapy are the intended participants.
✕Probably not a fit
People who are not starting or changing biologic/targeted synthetic DMARDs or whose pain is unrelated to inflammatory joint disease may not receive direct benefit from participation.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is an exploratory, longitudinal observational project enrolling patients with inflammatory joint diseases who initiate or switch biological or targeted synthetic DMARD therapy. Participants will undergo repeated clinical assessments over time to identify phenotypes and endotypes of chronic pain, with a special focus on measures of central sensitization and cognitive functioning. The study will examine how these pain subtypes and risk factors relate to disease activity, treatment response, and daily functioning. Collected data aim to clarify causes and consequences of chronic pain and guide more personalized pain-management approaches.
Why it matters
Potential benefit: If successful, the findings could lead to more personalized pain management and better matching of treatments for people with inflammatory joint diseases.
How similar studies have gone: Prior work has linked central sensitization and cognitive factors to chronic pain in arthritis, but comprehensive longitudinal phenotyping tied to biologic/targeted synthetic DMARD starts or switches is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * All patients who initiate or switch biological or targeted synthetic DMARDs Exclusion Criteria: * None
Where it's running
-
Diakonhjemmet Hospital
Oslo, Norway Recruiting
Study contacts
- Study coordinator: Ida K Haugen, MD PhD
- Email: ida.k.haugen@gmail.com
- Phone: +47 95859884
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.