Comparing two surgical treatments for CMC arthritis
Official title: A Randomized Prospective Multicenter Study Comparing Suture Button Suspensionplasty (SBS) with Ligament Reconstruction and Tendon Interposition (LRTI)
Run by Fraser Orthopaedic Research Society · NCT05111405 · Data updated 2026-11-12
This study is testing two different surgical options for people with CMC arthritis to see which one helps relieve pain better and gets them back to their normal activities faster.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 50 Years and up |
| Sex | All |
| Enrollment | 138 (estimated) |
| Sponsor | Fraser Orthopaedic Research Society Research network |
| Locations | 2 sites (Calgary, Alberta and 1 other locations) |
| Status | Recruiting |
| Started | June 20, 2022 |
| Main results expected | February 2026 |
| Study ends | May 2026 |
| Registry record updated | February 28, 2025 |
| Trial ID | NCT05111405 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are individuals aged fifty years or older with isolated carpometacarpal osteoarthritis who have not responded to non-operative management.
✕Probably not a fit
Patients who have had previous surgery for CMC arthritis or have other significant hand or wrist pathologies may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial is a multi-center, randomized control trial that compares two standard surgical treatments for carpometacarpal (CMC) arthritis: trapezial excision with or without soft tissue interposition and/or ligament reconstruction (LRTI) versus suture button suspension arthroplasty (SBS). The study aims to evaluate the effectiveness of SBS in providing pain relief compared to LRTI, while also assessing factors such as operating room time, grip strength, and return to work times. Patient-reported outcomes will be collected at multiple time points over the course of one year to measure the success of each intervention.
Why it matters
Potential benefit: If successful, this study could provide patients with a more effective surgical option for pain relief from CMC arthritis.
How similar studies have gone: While there have been biomechanical and clinical studies comparing related procedures, this is the first randomized control trial specifically comparing LRTI with SBS.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age fifty years or older * Isolated carpometacarpal (trapeziometacarpal) osteoarthritis * Failure to respond to non-operative management * Willing and able to consent on their own behalf and follow the protocol and clinical visits as described * Able to read and understand English or have interpreter available Exclusion Criteria: * Previous surgery for CMC arthritis * Duration of symptoms for less than 6 months * Greater than or equal to 30 degrees of ipsilateral metacarpophalangeal (MCP) hyperextension * Scaphotrapeziotrapezoidal (stage 4 CMC) arthritis * Other significant ipsilateral wrist or hand pathology * A history of inflammatory arthropathy * A requirement for concomitant surgery for another condition * Any previous hand or wrist fracture * Likely problems, in the judgement of the investigators, with maintaining follow-up (i.e. patients with no fixed address, not mentally competent to give consent, intellectually challenged patients without adequate support, etc.)
Where it's running
-
South Campus Research Unit for Bone and Soft Tissue
Calgary, Alberta, Canada Recruiting -
Fraser Orthopaedic Research Society
New Westminster, British Columbia, Canada Recruiting
Study contacts
- Study coordinator: Bertrand Perey
- Email: bperey@shaw.ca
- Phone: 604-553-3247
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.