Setbp1’s role in how joint cells behave during inflammatory arthritis
Official title: Uncovering the role of Setbp1 in fibroblast-like synoviocytes during inflammatory arthritis
Funded at Emory University · NIH-11398188 · Data updated 2026-11-12
This project looks at how a protein called SETBP1 affects delicate joint cells (FLS) that drive inflammation in arthritis, with potential implications for better treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | September 6, 2017 |
| Project end | July 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $415,871 |
| NIH project number | 5R01AR070736-08 |
| Project ID | NIH-11398188 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with inflammatory arthritis (e.g., rheumatoid arthritis, psoriatic arthritis, juvenile idiopathic arthritis) could potentially benefit from future therapies derived from this work.
✕Less likely to help
This preclinical research may not directly benefit patients in the short term but could inform future treatments.
What this research studies
If you have inflammatory arthritis, the researchers aim to understand why joint-damaging cells stay troublemakers even after inflammation subsides. They will study SETBP1, a protein that helps turn genes on or off, to see how it shapes the “memory” of these cells in the joint. The work combines lab studies of cell behavior with analyses of epigenetic changes to identify what keeps FLS in their aggressive state. By uncovering these molecular pathways, the goal is to point toward new ways to calm the disease and protect joints.
Why it matters
Potential benefit: Finding how SETBP1 drives harmful FLS behavior could lead to new therapies that prevent joint damage in inflammatory arthritis.
How similar studies have gone: Prior studies link epigenetic changes to FLS aggression, with this project exploring SETBP1 as a key regulator; success in similar avenues has informed potential targets in arthritis.
Where this research is happening
-
Emory University
Atlanta, United States Active
Researchers
- Principal investigator: Bhattaram, Pallavi — Emory University
- Study coordinator: Bhattaram, Pallavi
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.