Understanding how aging affects aortic valve disease
Engineered models of age-related biochemical, biophysical, and hormonal changes to elucidate mechanisms of aortic valve disease onset
['FUNDING_R01'] · UNIVERSITY OF COLORADO DENVER · NIH-11003747
This study is looking into how age and gender affect aortic valve disease, which is common in older adults, by creating models to see how heart valves change as we get older, so we can better understand why aging is a big risk factor and how it impacts men and women differently.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF COLORADO DENVER (nih funded) |
| Locations | 1 site (Aurora, UNITED STATES) |
| Trial ID | NIH-11003747 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms behind aortic valve disease, particularly how age and sex differences influence its onset. By creating engineered models that mimic age-related changes, the study aims to explore the structural and functional alterations in heart valves as people age. The research will utilize in vitro approaches to better understand the biological questions surrounding this condition, which is prevalent in older adults. The goal is to identify why aging is a significant risk factor and how it differs between men and women.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals aged 65 and older, particularly those at risk for aortic valve disease.
Not a fit: Patients under the age of 65 or those without risk factors for aortic valve disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for aortic valve disease in older adults.
How similar studies have performed: While there has been limited research specifically mimicking age-related changes in aortic valve disease, similar approaches in other age-related conditions have shown promise.
Where this research is happening
Aurora, UNITED STATES
- UNIVERSITY OF COLORADO DENVER — Aurora, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MASTERS, KRISTYN S — UNIVERSITY OF COLORADO DENVER
- Study coordinator: MASTERS, KRISTYN S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.