How aortic valve function and heart devices affect blood transport in older adults with valve disease

Who could benefit from this research

What this research studies

This research investigates the impact of aortic valve hemodynamics and left ventricular assist devices (LVADs) on the biological transport processes involved in calcific aortic valve disease. It aims to develop a computational tool to model the transport of Low-Density Lipoprotein (LDL) near the aortic valve, which is crucial for understanding the calcification process. By examining how the movement of the aortic valve leaflets influences LDL transport and how LVADs interact with this process, the research seeks to uncover important relationships that could inform treatment strategies for affected patients.

Why it matters

Where this research is happening

• University of North Texas
  Denton, United States Active

Researchers

• Principal investigator: Sadat, Hamid — University of North Texas
• Study coordinator: Sadat, Hamid

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About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.