How aortic valve function and heart devices affect blood transport in older adults with valve disease
The Influence of Aortic Valve Hemodynamics and LVAD on bio-transport processes in Calcific Aortic Valve Disease
This study is looking at how the movement of the aortic valve and the use of heart pumps (LVADs) affect the way bad cholesterol (LDL) moves around the heart, which is important for understanding and treating calcific aortic valve disease.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of North Texas NIH-funded |
| Lab location | 1 site (Denton, United States) |
| Project ID | NIH-10292320 on NIH RePORTER |
What this research studies
This research investigates the impact of aortic valve hemodynamics and left ventricular assist devices (LVADs) on the biological transport processes involved in calcific aortic valve disease. It aims to develop a computational tool to model the transport of Low-Density Lipoprotein (LDL) near the aortic valve, which is crucial for understanding the calcification process. By examining how the movement of the aortic valve leaflets influences LDL transport and how LVADs interact with this process, the research seeks to uncover important relationships that could inform treatment strategies for affected patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are elderly individuals over 65 years old who are experiencing calcific aortic valve disease or are supported by LVADs.
Not a fit: Patients with aortic valve disease who are not elderly or do not have LVAD support may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved management and treatment options for older adults suffering from calcific aortic valve disease.
How similar studies have performed: While there have been numerous studies on aortic valve hemodynamics, this specific approach to modeling LDL transport in relation to LVADs is novel and has not been extensively tested.
Where this research is happening
Denton, United States
- University of North Texas — Denton, United States (Active)
Researchers
- Principal investigator: Sadat, Hamid — University of North Texas
- Study coordinator: Sadat, Hamid
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.