Investigating the role of cadherin-11 in heart valve disease in older adults
Cadherin-11 in calcific aortic valve disease
This study is looking at how a protein called cadherin-11 affects calcific aortic valve disease in people over 65, to see if targeting it can help slow down or even reverse the disease, and to find out if it can help doctors decide when to treat patients with aortic stenosis.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University NIH-funded |
| Lab location | 1 site (Nashville, UNITED STATES) |
| Project ID | NIH-11231564 on NIH RePORTER |
What this research studies
This research focuses on calcific aortic valve disease (CAVD), a common condition affecting individuals over 65 years of age. The study aims to understand how cadherin-11, a protein involved in cell interactions, contributes to the progression of this disease. Researchers will explore the mechanisms by which cadherin-11 influences heart valve cells and assess whether targeting this protein can halt or even reverse the disease's progression. Additionally, the study will evaluate cadherin-11 as a potential biomarker to help determine the best timing for interventions in patients with aortic stenosis.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals aged 65 and older who are experiencing symptoms of aortic stenosis or calcific aortic valve disease.
Not a fit: Patients under the age of 65 or those without aortic stenosis or calcific aortic valve disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that effectively slow or reverse the progression of calcific aortic valve disease in older adults.
How similar studies have performed: Previous research has shown promising results in targeting similar pathways in cardiovascular diseases, suggesting potential for success in this novel approach.
Where this research is happening
Nashville, UNITED STATES
- Vanderbilt University — Nashville, United States (Active)
Researchers
- Principal investigator: Merryman, William D — Vanderbilt University
- Study coordinator: Merryman, William D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.