Observing the progression of moderate aortic valve disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational cohort study aims to evaluate and predict the progression of moderate aortic valve stenosis and regurgitation through clinical characterization, biological assessments, echocardiography, and computed tomography. Conducted at the Second Affiliated Hospital of Zhejiang University School of Medicine, the study seeks to understand the factors influencing disease progression and the potential impact of device or drug therapies. The research addresses the lack of consensus on treatment for moderate aortic valve diseases and emphasizes the importance of regular monitoring for these patients.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* At least 18 years old
* Be willing and able to provide informed consent to participate in the study
* Patient has moderate aortic valve diseases with echocardiographically derived criteria

Exclusion Criteria:

* Severe aortic valve diseases with echocardiographically derived criteria or planned cardiac surgery or likely need for surgery within 6 months
* Patients who have undergone elective transfemoral transcatheter aortic valve replacement
* Life expectancy is less than 12 months due to non-heart disease (such as cancer, chronic liver disease, chronic kidney disease, or chronic end-stage lung disease, etc.)
* Severe dementia (cannot sign research informed consent, cannot take care of themselves or complete the study visit)
* Acute pulmonary oedema or cardiogenic shock
* The investigator believes that the patient is not suitable to participate in the study or complete the follow-up prescribed by the protocol from other medical, social and psychological aspects
* The patient is currently participating in another randomized study

Where it's running

• Second Affiliated Hospital of Zhejiang University, School of Medicine
  Hangzhou, Zhejiang, China Recruiting

Study contacts

• Principal investigator: Jianan Wang, Dorctor — Second Affiliated Hospital of Zhejiang University, School of Medicine
• Study coordinator: Xianbao Liu, Dorctor
• Email: liuxb@zju.edu.cn
• Phone: 086-571-87784705

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• EmStop Embolic Protection System for TAVR in Aortic Valve Stenosis

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• Tracking progression and consequences of heart valve disease

  This project will follow adults with moderate or worse valve disease to see if clinical tests and imaging can predict when their condition will get worse.

  Recruiting at 15 sites Second Affiliated Hospital, Zhejiang University, School of Medicine · Fuzhou, Fujian and 14 other locations · NCT07267117

• Real-world outcomes of the INSPIRIS RESILIA aortic valve in adults

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• Transcatheter JenaValve or J-Valve treatment for severe aortic regurgitation

  This project will try two transcatheter heart valves (JenaValve and J-Valve) to treat people with severe symptomatic aortic regurgitation who are high risk for open-heart surgery.

  Recruiting Prince of Wales Hospital, Shatin, Hong Kong · Hong Kong, Shatin · NCT07021612

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.