Assessing risk factors and prognosis for aortic valve diseases
Official title: Aortic Valve Diseases RISk facTOr assessmenT and Prognosis modeL Construction (ARISTOTLE)
Run by Sun Yat-sen University · NCT06069232 · Data updated 2026-11-12
This study is trying to find out what factors affect the health of people with aortic valve disease while they're in the hospital, to help doctors make better decisions about their care.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 100 Years |
| Sex | All |
| Enrollment | 2000 (estimated) |
| Sponsor | Sun Yat-sen University Academic / other |
| Locations | 7 sites (Guangzhou, Guangdong and 6 other locations) |
| Status | Recruiting |
| Started | March 1, 2021 |
| Main results expected | March 1, 2028 |
| Study ends | March 1, 2028 |
| Registry record updated | October 12, 2023 |
| Trial ID | NCT06069232 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are adults aged 18 and older who have been diagnosed with aortic valve disease.
✕Probably not a fit
Patients who have undergone aortic valve replacement at baseline will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This multicenter cohort study focuses on patients diagnosed with aortic valve disease, including aortic insufficiency and aortic stenosis, during hospitalization. The study aims to evaluate prognostic risk factors and construct a predictive model to guide clinical decision-making. By following patients over time, the study will assess all-cause mortality and cardiovascular events as primary and secondary outcomes, respectively.
Why it matters
Potential benefit: If successful, this study could provide valuable insights into the risk factors associated with aortic valve diseases, leading to improved patient management and outcomes.
How similar studies have gone: Other studies have successfully identified risk factors and prognostic models for cardiovascular diseases, suggesting that this approach has potential for meaningful insights.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * age ≥ 18 * diagnosed as aortic valve disease Exclusion Criteria: * aortic valve replacement at baseline
Where it's running
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First Affiliated Hospital, Sun Yat-Sen University
Guangzhou, Guangdong, China Recruiting -
Third Affiliated Hospital, Sun Yat-Sun University
Guangzhou, Guangdong, China Recruiting -
Jieyang People's Hospital
Jieyang, Guangdong, China Recruiting -
Second Affiliated Hospital of Shantou University Medical College
Shantou, Guangdong, China Recruiting -
Eighth Affiliated Hospital, Sun Yat-Sen University
Shenzhen, Guangdong, China Recruiting -
Affiliated Hospital of Guangdong Medical University
Zhanjiang, Guangdong, China Recruiting
Show 1 more location
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Zhongshan People's Hospital
Zhongshan, Guangdong, China Recruiting
Study contacts
- Principal investigator: xiaodong zhuang, PhD — First Affiliated Hospital, Sun Yat-Sen University
- Study coordinator: xiaodong zhuang, PhD
- Email: zhuangxd3@mail.sysu.edu.cn
- Phone: +86 13760755035
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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KONECT RESILIA Aortic Valved Conduit real-world use in adults needing valve and ascending aorta replacement
This study tests how the KONECT RESILIA aortic valved conduit performs in adults needing aortic valve and ascending aorta replacement.
-
Savvywire versus standard LV guidewires during transfemoral TAVI
For people 50 and older having transfemoral TAVI, researchers will compare the Savvywire and standard LV guidewires to see if the Savvywire improves pacing and procedure-related blood flow.
-
EmStop Embolic Protection System for TAVR in Aortic Valve Stenosis
This study tests whether the EmStop protective device can safely capture and remove debris during transcatheter aortic valve replacement in adults with severe aortic valve stenosis.
-
Tracking progression and consequences of heart valve disease
This project will follow adults with moderate or worse valve disease to see if clinical tests and imaging can predict when their condition will get worse.
-
Real-world outcomes of the INSPIRIS RESILIA aortic valve in adults
This registry will collect real-world data to see how the INSPIRIS RESILIA aortic valve performs in adults undergoing aortic valve replacement.
-
Transcatheter JenaValve or J-Valve treatment for severe aortic regurgitation
This project will try two transcatheter heart valves (JenaValve and J-Valve) to treat people with severe symptomatic aortic regurgitation who are high risk for open-heart surgery.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.