Clinical trial Recruiting at 7 sites Observational Ages 18 to 100

Assessing risk factors and prognosis for aortic valve diseases

Official title: Aortic Valve Diseases RISk facTOr assessmenT and Prognosis modeL Construction (ARISTOTLE)

Run by Sun Yat-sen University · NCT06069232 · Data updated 2026-11-12

This study is trying to find out what factors affect the health of people with aortic valve disease while they're in the hospital, to help doctors make better decisions about their care.

Quick facts

Study typeObservational
Ages18 Years to 100 Years
SexAll
Enrollment2000 (estimated)
SponsorSun Yat-sen University
Academic / other
Locations7 sites (Guangzhou, Guangdong and 6 other locations)
StatusRecruiting
StartedMarch 1, 2021
Main results expectedMarch 1, 2028
Study endsMarch 1, 2028
Registry record updatedOctober 12, 2023
Trial IDNCT06069232 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are adults aged 18 and older who have been diagnosed with aortic valve disease.

Probably not a fit

Patients who have undergone aortic valve replacement at baseline will not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This multicenter cohort study focuses on patients diagnosed with aortic valve disease, including aortic insufficiency and aortic stenosis, during hospitalization. The study aims to evaluate prognostic risk factors and construct a predictive model to guide clinical decision-making. By following patients over time, the study will assess all-cause mortality and cardiovascular events as primary and secondary outcomes, respectively.

Why it matters

Potential benefit: If successful, this study could provide valuable insights into the risk factors associated with aortic valve diseases, leading to improved patient management and outcomes.

How similar studies have gone: Other studies have successfully identified risk factors and prognostic models for cardiovascular diseases, suggesting that this approach has potential for meaningful insights.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* age ≥ 18
* diagnosed as aortic valve disease

Exclusion Criteria:

* aortic valve replacement at baseline

Where it's running

  • First Affiliated Hospital, Sun Yat-Sen University
    Guangzhou, Guangdong, China
    Recruiting
  • Third Affiliated Hospital, Sun Yat-Sun University
    Guangzhou, Guangdong, China
    Recruiting
  • Jieyang People's Hospital
    Jieyang, Guangdong, China
    Recruiting
  • Second Affiliated Hospital of Shantou University Medical College
    Shantou, Guangdong, China
    Recruiting
  • Eighth Affiliated Hospital, Sun Yat-Sen University
    Shenzhen, Guangdong, China
    Recruiting
  • Affiliated Hospital of Guangdong Medical University
    Zhanjiang, Guangdong, China
    Recruiting
Show 1 more location
  • Zhongshan People's Hospital
    Zhongshan, Guangdong, China
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.