Understanding and treating congenital aortic valve disease
Mechanisms and Therapeutics for Congenital Aortic Valve Disease
This study is looking into congenital aortic valve disease to understand what causes it and to find new treatments that might help people avoid surgery, especially by exploring genetic factors and potential medications.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Research Inst Nationwide Children's Hosp NIH-funded |
| Lab location | 1 site (Columbus, United States) |
| Project ID | NIH-11133027 on NIH RePORTER |
What this research studies
This research investigates congenital aortic valve disease, focusing on the mechanisms behind its development and potential therapeutic options. It aims to identify genetic factors, such as NOTCH1 and GATA5, that contribute to this condition, which affects heart valve formation. The study will explore pharmacologic therapies that could reduce the need for surgical interventions in patients with aortic valve stenosis. By utilizing both human genetic studies and murine models, the research seeks to uncover new treatment pathways for affected individuals.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with congenital aortic valve disease, particularly those with bicuspid aortic valve or aortic valve stenosis.
Not a fit: Patients with acquired aortic valve disease or those without congenital heart defects may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new medications that prevent the need for surgery in patients with congenital aortic valve disease.
How similar studies have performed: Previous research has successfully identified genetic links to congenital heart defects, suggesting that this approach may yield valuable insights and advancements.
Where this research is happening
Columbus, United States
- Research Inst Nationwide Children's Hosp — Columbus, United States (Active)
Researchers
- Principal investigator: Garg, Vidu — Research Inst Nationwide Children's Hosp
- Study coordinator: Garg, Vidu
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.