Understanding and treating congenital aortic valve disease
Official title: Mechanisms and Therapeutics for Congenital Aortic Valve Disease
Funded at Research Inst Nationwide Children's Hosp · NIH-11133027 · Data updated 2026-11-12
This study is looking into congenital aortic valve disease to understand what causes it and to find new treatments that might help people avoid surgery, especially by exploring genetic factors and potential medications.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Research Inst Nationwide Children's Hosp NIH-funded |
| Lab location | 1 site (Columbus, United States) |
| Project start | July 5, 2024 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $598,341 |
| NIH project number | 5R01HL175924-02 |
| Project ID | NIH-11133027 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with congenital aortic valve disease, particularly those with bicuspid aortic valve or aortic valve stenosis.
✕Less likely to help
Patients with acquired aortic valve disease or those without congenital heart defects may not benefit from this research.
What this research studies
This research investigates congenital aortic valve disease, focusing on the mechanisms behind its development and potential therapeutic options. It aims to identify genetic factors, such as NOTCH1 and GATA5, that contribute to this condition, which affects heart valve formation. The study will explore pharmacologic therapies that could reduce the need for surgical interventions in patients with aortic valve stenosis. By utilizing both human genetic studies and murine models, the research seeks to uncover new treatment pathways for affected individuals.
Why it matters
Potential benefit: If successful, this research could lead to new medications that prevent the need for surgery in patients with congenital aortic valve disease.
How similar studies have gone: Previous research has successfully identified genetic links to congenital heart defects, suggesting that this approach may yield valuable insights and advancements.
Where this research is happening
-
Research Inst Nationwide Children's Hosp
Columbus, United States Active
Researchers
- Principal investigator: Garg, Vidu — Research Inst Nationwide Children's Hosp
- Study coordinator: Garg, Vidu
Related research
Other NIH-funded projects on the same topics.
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GATA4's role in why some hearts are born with two valve cusps
A study in mice and human genetics will look at how a specific GATA4 gene change leads to bicuspid aortic valve and related heart problems.
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AI-guided prediction of aortic valve disease progression using CT scans
A patient-friendly AI tool analyzes CT angiography data to predict how quickly aortic valve disease may advance and the risk of complications after valve replacement.
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Small molecule therapy for calcific aortic valve disease
A new drug candidate is being studied to slow or stop calcification of the aortic valve in adults with valve disease.
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Understanding and treating congenital aortic valve problems
This project develops medicines targeting the genetic and molecular causes of malformed aortic valves to help people born with bicuspid or other congenital valve problems avoid or delay surgery.
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Understanding why some people with calcific aortic valve disease develop atherogenic vs non-atherogenic patterns
This NIH-funded project explores why some people with aortic valve disease have accompanying atherosclerosis while others do not, using human genetics, proteomics, and imaging data to uncover differences that could lead to better treatments.
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Lab-grown models of how aging and sex affect aortic valve narrowing
Researchers will build lab-grown heart valve models that mimic aging and male/female differences to learn why older adults develop aortic valve narrowing.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.