Using a natural compound to treat calcific aortic valve disease
Develop natural compound emodin as a novel therapy for calcific aortic valve disease
This study is looking at a new treatment for calcific aortic valve disease, a heart condition that many older adults face, by using a natural compound called emodin to see if it can help stop or even reverse the disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Acepre, LLC NIH-funded |
| Lab location | 1 site (Columbia, United States) |
| Project ID | NIH-10822082 on NIH RePORTER |
What this research studies
This research focuses on calcific aortic valve disease (CAVD), a serious heart condition that affects many older adults. The study aims to develop a novel therapy using a natural compound called emodin, which has shown promise in blocking the progression of valve calcification in laboratory settings. Researchers will investigate how this compound interacts with valve cells to potentially halt or reverse the disease process. The approach includes both in vitro assays and animal models to better understand the effectiveness of emodin in treating CAVD.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults, particularly those over 65 years of age, who are at risk for or currently suffering from calcific aortic valve disease.
Not a fit: Patients who are younger than 65 years or those with other forms of heart disease unrelated to calcific aortic valve disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a new non-surgical treatment option for patients suffering from calcific aortic valve disease.
How similar studies have performed: While the use of emodin in this context is novel, previous research has indicated that targeting TGFβ signaling may be a promising approach for treating calcific aortic valve disease.
Where this research is happening
Columbia, United States
- Acepre, LLC — Columbia, United States (Active)
Researchers
- Principal investigator: Azhar, Mohamad — Acepre, LLC
- Study coordinator: Azhar, Mohamad
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.