Identifying biomarkers for diagnosing aortic dissection in emergency patients
Official title: Potential Diagnostic Biomarkers for Aortic Dissection in the Emergency Department: the Aggrecan, Desmosine, D-dimer-Emergency Department (ADD-ED) Study
Run by Chinese University of Hong Kong · NCT06065306 · Data updated 2026-11-12
This study is testing if certain blood markers can help doctors quickly diagnose aortic dissection in emergency patients.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 47 (estimated) |
| Sponsor | Chinese University of Hong Kong Academic / other |
| Locations | 1 site (Shatin, NT) |
| Status | Recruiting |
| Started | June 18, 2023 |
| Main results expected | December 31, 2026 |
| Study ends | December 31, 2027 |
| Registry record updated | October 22, 2026 |
| Trial ID | NCT06065306 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are adults aged 18 and older who present to the emergency department with symptoms suggestive of aortic dissection and have a confirmed diagnosis.
✕Probably not a fit
Patients under 18 years old, pregnant individuals, or those who have undergone surgery or stenting prior to recruitment may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to evaluate the effectiveness of specific biomarkers, including desmosine, D-dimer, and aggrecan, in diagnosing aortic dissection in patients presenting to the emergency department. It will measure the plasma levels of these biomarkers in patients confirmed to have aortic dissection within the first 24 hours of symptom onset. The study will also assess how these biomarker levels correlate with clinical outcomes, providing insights into their diagnostic performance.
Why it matters
Potential benefit: If successful, this study could lead to quicker and more accurate diagnoses of aortic dissection, potentially improving patient outcomes.
How similar studies have gone: While the use of biomarkers in diagnosing aortic dissection is an emerging field, similar studies have shown promise in identifying effective diagnostic tools, making this approach both relevant and potentially impactful.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age ≥ 18 years * Presentation to the ED with first 24 hours of symptoms suggesting AD, including chest pain, upper back pain, syncope of unknown cause, symptoms of any acute perfusion deficit * Confirmed AD * the diagnosis of AD adjudicated by an independent expert panel at hospital discharge or death, whichever comes first * The expert panel will consist of (1) a specialist in Emergency Medicine and (2) a specialist in Cardiology and (3) a specialist in Cardiothoracic Surgery. Exclusion Criteria: * Age \<18 years old * Pregnancy * Surgery or stenting performed before recruitment
Where it's running
-
Prince of Wales Hospital
Shatin, Nt, Hong Kong Recruiting
Study contacts
- Study coordinator: Colin A Graham
- Email: cagraham@cuhk.edu.hk
- Phone: +85235051033
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Pregnancy-Related Aortic Dissection in China
This study looks at cases of aortic dissection that occur during pregnancy or shortly after, to understand outcomes for mothers and babies.
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Ketorolac to improve outcomes and prognosis in Stanford Type A aortic dissection
This trial will test whether giving ketorolac around emergency surgery helps adults (18–65) with Stanford Type A aortic dissection recover better and have fewer complications over 90 days.
-
WeFlow-EndoPatch for Distal Aortic Tear Repair in Chronic Dissection
This study tests whether the WeFlow-EndoPatch Aortic Endovascular Patch can safely and effectively seal distal tears in chronic aortic dissection compared with standard treatment.
-
Aortic arch single-branch covered stent graft for treating aortic dissection
This trial tests a single-branch covered stent graft in adults with Stanford Type B aortic dissection who need revascularization of the left subclavian artery.
-
Multicenter study on acute type A aortic dissection
This study is trying to learn more about patients with acute type A aortic dissection by looking at their health details, surgeries, and recovery to see what affects their outcomes.
-
Shape‑memory polymer to seal the false lumen and prevent aortic enlargement
This trial will try a shape‑memory polymer implant to seal the false lumen and stop aortic growth in adults with type B dissection or treated type A dissection who need false lumen repair.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.