Identifying biomarkers for diagnosing aortic dissection in emergency patients
Potential Diagnostic Biomarkers for Aortic Dissection in the Emergency Department: the Aggrecan, Desmosine, D-dimer-Emergency Department (ADD-ED) Study
This study is testing if certain blood markers can help doctors quickly diagnose aortic dissection in emergency patients.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 47 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Chinese University of Hong Kong Academic / other |
| Locations | 1 site (Sha Tin, NT) |
| Trial ID | NCT06065306 on ClinicalTrials.gov |
What this trial studies
This observational study aims to evaluate the effectiveness of specific biomarkers, including desmosine, D-dimer, and aggrecan, in diagnosing aortic dissection in patients presenting to the emergency department. It will measure the plasma levels of these biomarkers in patients confirmed to have aortic dissection within the first 24 hours of symptom onset. The study will also assess how these biomarker levels correlate with clinical outcomes, providing insights into their diagnostic performance.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 18 and older who present to the emergency department with symptoms suggestive of aortic dissection and have a confirmed diagnosis.
Not a fit: Patients under 18 years old, pregnant individuals, or those who have undergone surgery or stenting prior to recruitment may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to quicker and more accurate diagnoses of aortic dissection, potentially improving patient outcomes.
How similar studies have performed: While the use of biomarkers in diagnosing aortic dissection is an emerging field, similar studies have shown promise in identifying effective diagnostic tools, making this approach both relevant and potentially impactful.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age ≥ 18 years * Presentation to the ED with first 24 hours of symptoms suggesting AD, including chest pain, upper back pain, syncope of unknown cause, symptoms of any acute perfusion deficit * Confirmed AD * the diagnosis of AD adjudicated by an independent expert panel at hospital discharge or death, whichever comes first * The expert panel will consist of (1) a specialist in Emergency Medicine and (2) a specialist in Cardiology and (3) a specialist in Cardiothoracic Surgery. Exclusion Criteria: * Age \<18 years old * Pregnancy * Surgery or stenting performed before recruitment
Where this trial is running
Sha Tin, NT
- Prince of Wales Hospital — Sha Tin, Nt, Hong Kong (Recruiting)
Study contacts
- Study coordinator: Colin A Graham
- Email: cagraham@cuhk.edu.hk
- Phone: +85235051033
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.