Improving outcomes for patients with aortic dissection
1/2 IMPRoving Outcomes in Vascular DisEase - Aortic Dissection (IMPROVE-AD)
['FUNDING_OTHER'] · DUKE UNIVERSITY · NIH-11027406
This study is looking at two different ways to treat people with uncomplicated type B aortic dissection to see which one works better: one approach combines medication with a quick surgery, while the other relies on medication and careful monitoring, and we're inviting 1,100 participants from across the U.S. to help us find the best option for managing this serious condition.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | DUKE UNIVERSITY (nih funded) |
| Locations | 1 site (DURHAM, UNITED STATES) |
| Trial ID | NIH-11027406 on ClinicalTrials.gov |
What this research studies
This research investigates the effectiveness of two treatment strategies for patients with uncomplicated type B aortic dissection. It compares medical therapy combined with immediate thoracic endovascular aortic repair (TEVAR) against medical therapy with ongoing monitoring for any deterioration. The study aims to enroll 1,100 participants across the United States and will involve experienced clinical and statistical teams to ensure robust data collection and analysis. Patients will be monitored closely to determine the best management approach for this serious condition.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with uncomplicated type B aortic dissection who meet specific inclusion criteria.
Not a fit: Patients with complicated type B aortic dissection or those who do not meet the study's eligibility criteria may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment protocols that enhance survival and quality of life for patients with aortic dissection.
How similar studies have performed: This research is novel in its scale and approach, as no previous studies of this size have been conducted specifically for uncomplicated type B aortic dissection management.
Where this research is happening
DURHAM, UNITED STATES
- DUKE UNIVERSITY — DURHAM, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PATEL, MANESH R — DUKE UNIVERSITY
- Study coordinator: PATEL, MANESH R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Aortic Diseases