Non-invasive 4D flow MRI to predict risk in aortic dissection
Official title: Non-invasive hemodynamic and biomechanic imaging methods for early risk prediction in aortic dissection
Funded at University of Wisconsin-Madison · NIH-11385397 · Data updated 2026-11-12
A study using 4D flow MRI to help doctors predict which patients with aortic dissection are at higher long-term risk so they can tailor treatment.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project start | July 1, 2023 |
| Project end | April 30, 2028 |
| Funding year | 2026 |
| Award (this year) | $480,255 |
| NIH project number | 5R01HL170059-04 |
| Project ID | NIH-11385397 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults diagnosed with aortic dissection who are being considered for or managed with TEVAR or medical therapy.
✕Less likely to help
Patients without aortic dissection or those not undergoing imaging interventions are unlikely to benefit.
What this research studies
This project uses cutting-edge 4D flow MRI and related imaging to measure how blood moves and how the aorta fights back in people with aortic dissection. By capturing dynamic functional information early, researchers aim to identify patients who may benefit from timely interventions like TEVAR. The study focuses on translating advanced imaging findings into risk predictions that complement traditional anatomy-based metrics. If successful, the approach could guide personalized treatment decisions and improve long-term outcomes for patients with this condition.
Why it matters
Potential benefit: If successful, patients with aortic dissection could receive more precise treatment decisions, potentially reducing unnecessary procedures and improving survival.
How similar studies have gone: Previous work suggests that advanced functional imaging can reveal hemodynamic factors linked to outcomes in vascular diseases, but 4D-flow MRI for long-term risk prediction in aortic dissection is an area of active development.
Where this research is happening
-
University of Wisconsin-Madison
Madison, United States Active
Researchers
- Principal investigator: Burris, Nicholas Scott — University of Wisconsin-Madison
- Study coordinator: Burris, Nicholas Scott
Related research
Other NIH-funded projects on the same topics.
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Improving Outcomes in Vascular Disease for Aortic Dissection: Upfront TEVAR vs Surveillance
A large US study will compare starting treatment with a repair procedure plus medicine to medicine alone with careful follow-up in people with uncomplicated type B aortic dissection.
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Improving Outcomes in Aortic Dissection: Upfront TEVAR vs Surveillance (IMPROVE-AD) for Uncomplicated Type B Dissection
A large, patient-friendly study will compare starting with medicine plus an upfront TEVAR procedure versus medicine with careful monitoring for people with uncomplicated type B aortic dissection.
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IMPROVE-AD: Better outcomes for uncomplicated type B aortic dissection
A large patient study in the US will compare starting with medical care plus upfront TEVAR versus medical care with monitoring alone to see which approach leads to better outcomes for people with uncomplicated type B aortic dissection.
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Upfront TEVAR plus medical therapy vs lifelong monitoring for uncomplicated type B aortic dissection
A large US study tests whether adding early TEVAR to standard medical care helps people with uncomplicated type B aortic dissection live better than medical care alone with ongoing monitoring.
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Early aortic stent plus medicine versus medicine with watchful waiting for uncomplicated type B aortic dissection
This compares giving an early aortic stent graft plus medicines to using medicines with close follow-up for people with uncomplicated type B aortic dissection to find which approach leads to better outcomes.
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Improving care for people with type B aortic dissection
This study will compare immediate stent-graft repair plus medicines to medicines with watchful waiting for people with uncomplicated type B aortic dissection.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.