Identifying risks in patients with uncomplicated type B aortic dissection
Official title: Risk stratification of uncomplicated type B aortic dissection using clinical and engineering analysis
Funded at Emory University · NIH-10897983 · Data updated 2026-11-12
This study is looking at patients with uncomplicated type B aortic dissection to find out who might need earlier treatment instead of just standard care, so they can get the best help possible.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | September 20, 2021 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $534,965 |
| NIH project number | 5R01HL155537-04 |
| Project ID | NIH-10897983 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with uncomplicated type B aortic dissection who are currently receiving optimal medical therapy.
✕Less likely to help
Patients with complicated type B aortic dissection requiring immediate surgical intervention may not benefit from this research.
What this research studies
This research focuses on patients with uncomplicated type B aortic dissection, a serious condition where a tear in the aorta can lead to severe complications. The study aims to develop a risk stratification model that helps predict which patients may not respond well to standard medical treatment and may need earlier intervention. By analyzing clinical and anatomical data from a large patient database, the researchers hope to improve patient outcomes through better decision-making regarding treatment timing. This approach combines clinical assessments with advanced imaging techniques to enhance understanding of the condition.
Why it matters
Potential benefit: If successful, this research could lead to improved survival rates and better long-term outcomes for patients with uncomplicated type B aortic dissection.
How similar studies have gone: Previous research has shown promise in using risk stratification models for other cardiovascular conditions, indicating potential success for this novel approach.
Where this research is happening
-
Emory University
Atlanta, United States Active
Researchers
- Principal investigator: Leshnower, Bradley Graham — Emory University
- Study coordinator: Leshnower, Bradley Graham
Related research
Other NIH-funded projects on the same topics.
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Improving Outcomes in Vascular Disease for Aortic Dissection: Upfront TEVAR vs Surveillance
A large US study will compare starting treatment with a repair procedure plus medicine to medicine alone with careful follow-up in people with uncomplicated type B aortic dissection.
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Improving Outcomes in Aortic Dissection: Upfront TEVAR vs Surveillance (IMPROVE-AD) for Uncomplicated Type B Dissection
A large, patient-friendly study will compare starting with medicine plus an upfront TEVAR procedure versus medicine with careful monitoring for people with uncomplicated type B aortic dissection.
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IMPROVE-AD: Better outcomes for uncomplicated type B aortic dissection
A large patient study in the US will compare starting with medical care plus upfront TEVAR versus medical care with monitoring alone to see which approach leads to better outcomes for people with uncomplicated type B aortic dissection.
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Upfront TEVAR plus medical therapy vs lifelong monitoring for uncomplicated type B aortic dissection
A large US study tests whether adding early TEVAR to standard medical care helps people with uncomplicated type B aortic dissection live better than medical care alone with ongoing monitoring.
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Non-invasive 4D flow MRI to predict risk in aortic dissection
A study using 4D flow MRI to help doctors predict which patients with aortic dissection are at higher long-term risk so they can tailor treatment.
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Early aortic stent plus medicine versus medicine with watchful waiting for uncomplicated type B aortic dissection
This compares giving an early aortic stent graft plus medicines to using medicines with close follow-up for people with uncomplicated type B aortic dissection to find which approach leads to better outcomes.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.