Using sivelestat to protect lung function after heart surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the protective effects of sivelestat, an immunomodulatory therapy, on patients undergoing cardiovascular surgery. It aims to determine whether administering sivelestat during the acute phase of cardiovascular diseases can reduce the incidence of systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction syndrome (MODS). The study will enroll patients diagnosed with type A acute aortic syndrome who are scheduled for emergency surgery, comparing outcomes between those receiving sivelestat and a control group. The trial is designed to provide insights into the potential benefits of sivelestat in improving postoperative recovery.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* The patients are conformed to 2010 ACC/AHA guidelines for the diagnosis and treatment of thoracic aortic disease (TAD) within two weeks of onset;
* Patients with type A acute aortic syndrome confirmed clinically and radiologically and planning to undergo emergency surgery were enrolled.
* The patients' age between 18 \~90 years old.
* Agree to participate in the study and sign the informed consent.

Exclusion Criteria:

* Patients allergic to sivelestat sodium;
* Lactating women and pregnant women;
* Patients with mental diseases, drug and alcohol dependence;
* Refuse to participate in this study and refuse to sign the informed consent.

Where it's running

• Beijing Anzhen Hospital
  Beijing, China Recruiting
• The First Affiliated Hospital of Nanjing Medical University and Jiang ye-fan
  Nanjing, China Recruiting

Study contacts

• Study coordinator: Hong Liu, MD
• Email: dr.hongliu@foxmail.com
• Phone: +8618801281613

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.