Home › Trials › NCT05215587

Evaluating TEVAR for uncomplicated aortic dissection

Scandinavian Trial of Uncomplicated Aortic Dissection Therapy

Not applicable Interventional University of Aarhus · NCT05215587

This study is testing if adding a special procedure called TEVAR to standard treatment can help people with uncomplicated aortic dissection live longer and have better health outcomes.

Quick facts

PhaseNot applicable
Study typeInterventional
Enrollment554 (estimated)
Ages18 Years and up
SexAll
SponsorUniversity of Aarhus Academic / other
Locations28 sites (Aalborg and 27 other locations)
Trial IDNCT05215587 on ClinicalTrials.gov

What this trial studies

This clinical trial investigates the effectiveness of thoracic endovascular aortic repair (TEVAR) in improving 5-year survival rates for patients with uncomplicated Stanford type-B aortic dissection (uTBAD). Participants will be randomly assigned to receive either standard medical therapy alone or standard medical therapy combined with TEVAR. The study aims to provide robust evidence regarding the potential benefits of TEVAR, addressing uncertainties in its use for uncomplicated cases. Secondary outcomes will assess aortic-related mortality, neurological events, quality of life, and healthcare costs.

Who should consider this trial

Good fit: Ideal candidates are adults aged 18 or older with an uncomplicated Stanford type-B aortic dissection diagnosed within the last four weeks.

Not a fit: Patients with complicated aortic dissections, pre-existing aortic conditions requiring intervention, or significant comorbidities may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could provide evidence that TEVAR improves survival and quality of life for patients with uncomplicated aortic dissections.

How similar studies have performed: While there have been analyses suggesting potential benefits of TEVAR, this specific approach for uncomplicated dissections is novel and has not been extensively tested in randomized trials.

Eligibility criteria

Show full inclusion / exclusion criteria 
Inclusion Criteria:

All subjects, aged 18 or greater at the time of informed consent, admitted or referred to the participating vascular surgery site with an uTBAD of less than four weeks duration.

Exclusion Criteria:

* Subjects with no signed informed consent.
* Subjects presenting with a complicated type B aortic dissection according to the above definition.
* Subjects previously treated in their descending aorta, either open surgery or TEVAR.
* Subjects with pre-existing thoracoabdominal aortic aneurysm.
* Subjects with other aortic pathology with an indication for intervention that requires TEVAR.
* Subjects with traumatic aortic dissections.
* Subjects with an established connective tissue disease at the time of randomization, including but not limited to Marfans and Loeys-Dietz syndrome.
* Subjects with a clinically estimated life expectancy \< 2 years.
* Subjects with dementia.
* Pregnant or nursing subjects.
* Subjects with current sepsis.
* Subjects currently participating in other clinical interventional trials.

Where this trial is running

Aalborg and 27 other locations

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
View on ClinicalTrials.gov → Find more trials like this →
Conditions Aortic DissectionAorticdissectionTEVARendovascularvascular
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.