Understanding blood flow and outcomes in Type B aortic dissection using advanced MRI techniques
Official title: Linking in vivo hemodynamics with outcomes in Type B aortic dissection using 4D flow MRI
Funded at Northwestern University at Chicago · NIH-11036408 · Data updated 2026-11-12
This study is looking at how a special type of MRI can help doctors understand blood flow in patients with Type B aortic dissection, so they can better predict risks and improve treatment plans for those affected.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northwestern University at Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | February 15, 2024 |
| Project end | January 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $602,233 |
| NIH project number | 5R01HL168700-02 |
| Project ID | NIH-11036408 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Type B aortic dissection who are undergoing evaluation for treatment options.
✕Less likely to help
Patients with other types of aortic dissection or those who do not require intervention may not benefit from this research.
What this research studies
This research investigates how advanced 4D flow MRI can be used to assess blood flow dynamics in patients with Type B aortic dissection. By measuring various hemodynamic parameters, such as flow patterns and pressure, the study aims to better predict adverse outcomes related to this condition. The approach involves systematic imaging and analysis to identify which specific blood flow characteristics are most indicative of patient risk. This could lead to improved treatment planning and patient management.
Why it matters
Potential benefit: If successful, this research could enhance the ability to predict complications in patients with Type B aortic dissection, leading to better treatment outcomes.
How similar studies have gone: Previous pilot studies have shown promising results using similar 4D flow MRI techniques, indicating potential for success in this research.
Where this research is happening
-
Northwestern University at Chicago
Chicago, United States Active
Researchers
- Principal investigator: Allen, Bradley David — Northwestern University at Chicago
- Study coordinator: Allen, Bradley David
Related research
Other NIH-funded projects on the same topics.
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4D flow MRI to predict outcomes in Type B aortic dissection
A patient-centered look at how advanced 4D flow MRI can help predict who with Type B aortic dissection will have complications, guiding safer treatment decisions.
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Improving Outcomes in Vascular Disease for Aortic Dissection: Upfront TEVAR vs Surveillance
A large US study will compare starting treatment with a repair procedure plus medicine to medicine alone with careful follow-up in people with uncomplicated type B aortic dissection.
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Improving Outcomes in Aortic Dissection: Upfront TEVAR vs Surveillance (IMPROVE-AD) for Uncomplicated Type B Dissection
A large, patient-friendly study will compare starting with medicine plus an upfront TEVAR procedure versus medicine with careful monitoring for people with uncomplicated type B aortic dissection.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.