Condition

Amputation clinical trials and research

• 62Clinical trials
• 28NIH research projects
• 2New in 30 days
• 12Countries

Newest Amputation clinical trials

All recruiting trials (62)

• Hand prosthesis usability and performance evaluation for people with upper limb absence

  This study tests a new multi-articulating hand prosthesis to see if it performs better or differently than a participant’s own prosthesis.

  Recruiting Össur Iceland ehf · Dublin, Ohio · NCT07915700

• Core muscle function and balance in people with leg amputations

  This study tests how leg amputation affects core muscles and balance by comparing muscle thickness on the amputated side, the intact side, and healthy people using ultrasound.

  Recruiting Hacettepe University · Balçova, İzmir · NCT07875075

• Measuring bottom-of-foot pressures in people with lateral forefoot amputation due to diabetes

  Aiming to see if people with lateral forefoot amputation due to diabetes have higher pressures under remaining foot areas while walking.

  Recruiting at 2 sites Nanyang Technological University · Singapore and 1 other locations · NCT07865208

• Training Independent Muscle Activation From a Common Source

  A new surgical approach plus home training tests whether people with recent amputations or revision surgeries can gain improved muscle control.

  Recruiting Brigham and Women's Hospital · Boston, Massachusetts and 1 other locations · NCT07831278

• Powered ankle prosthesis with neural control and skin feedback for people with lower-leg amputation

  A powered ankle prosthesis that uses neural signals and skin stimulation to help people with a transtibial amputation walk more naturally.

  Recruiting Massachusetts Institute of Technology · Cambridge, Massachusetts · NCT07645729

• Personalized blood-thinner plan for leg artery disease after repair

  A personalized plan using a blood test to tailor antiplatelet therapy is being tested against standard treatment in adults with PAD after a procedure to restore blood flow.

  Recruiting at 2 sites Massachusetts General Hospital · Boston, Massachusetts and 1 other locations · NCT07613840

• Bio Leg: Advancing Mobility for people with above-knee amputations

  This study tests whether the Bio Leg powered knee improves walking function for people who already use a C-leg after an above-knee amputation.

  Recruiting University of Florida · Jacksonville, Florida · NCT07613502

• Socket Fit Testing System for above-the-knee prosthesis users

  A non-invasive device attached to a prosthetic socket is tested to see if it helps measure and improve socket fit for people with above-the-knee amputations.

  Recruiting University of Washington · Seattle, Washington · NCT07491614

• Neuropathic pain after childhood amputation

  This project sees how common phantom and residual limb neuropathic pain is and how it affects children and teens who had limb amputations.

  Recruiting Hopitaux de Saint-Maurice · Saint-Maurice · NCT07401966

• Community mobility using walking and wheeled devices after lower limb amputation

  Researchers will use wearable GPS and activity sensors to see how adults with lower limb amputation combine walking and wheeled mobility when they move around their communities.

  Recruiting Virginia Commonwealth University · Richmond, Virginia · NCT07387744

• Breizh Fabribus mobile workshop for on-site personalized assistive devices

  This project tests whether on-site 3D‑printed and laser‑cut devices made by the Breizh Fabribus mobile workshop help people with disabilities in Finistère perform targeted daily activities better within three months.

  Recruiting Fondation Ildys · Brest, Finistère · NCT07314099

• Slope Adaptive Foot to help veterans with below-knee amputation participate more in daily life

  Tests a new slope-adaptive foot to see if it helps veterans with below-knee amputation walk more comfortably and participate in activities, compared with a standard hydraulic foot.

  Recruiting VA Office of Research and Development · Minneapolis, Minnesota · NCT07266077

• Using AI to Improve Walking After Above-Knee Amputation

  This program tests whether adding artificial intelligence to gait training helps people with above-knee amputations walk better.

  Recruiting South Valley University · Banhā, Benha · NCT07265154

• How prosthetic foot stiffness affects outcomes after a below-knee amputation with bone-anchored or socket prostheses

  This trial will test whether using a softer, your usual, or a stiffer prosthetic foot changes comfort, walking function, and bone‑implant loading for adults with a single below‑knee amputation who use either a bone‑anchored limb or a socket prosthesis.

  Recruiting Phase 1 University of Colorado, Denver · Aurora, Colorado · NCT07263945

• Surgery or semi-occlusive dressing for a single finger amputation

  This study will test whether a semi-occlusive film dressing or surgery gives better hand function for adults who have lost the tip of a single finger.

  Recruiting Tampere University Hospital · Tampere · NCT07175675

• How two myoelectric control methods affect attention and daily function for people with below-the-elbow amputation

  This project tests whether pattern recognition control or traditional two-site direct myoelectric control is easier to use and more helpful for adults with below-the-elbow (transradial) limb loss when using a prosthesis.

  Recruiting at 2 sites Virginia Commonwealth University · Austin, Texas and 1 other locations · NCT07075042

• Home-based virtual reality treatment for phantom leg pain

  This program will test whether a home-based active virtual reality treatment can reduce phantom leg pain for adults after a lower-limb amputation.

  Recruiting at 3 sites Albert Einstein Healthcare Network · Philadelphia, Pennsylvania and 2 other locations · NCT07044323

• Effect of EMG sensor number and placement on control of below-elbow prosthetic arms

  This project will test whether changing the number and placement of myoelectric sensors helps adults with below-elbow limb absence control a prosthetic arm better while wearing a real device.

  Recruiting Liberating Technologies, Inc. · Chicago, Illinois and 1 other locations · NCT07011420

• Effect of EMG sensor number and placement on control of below-elbow prosthetic arms

  This project will test whether changing the number and placement of myoelectric sensors helps adults with below-elbow limb absence control a prosthetic arm better while wearing a real device.

  Recruiting Liberating Technologies, Inc. · Chicago, Illinois and 1 other locations · NCT07011420

• Microprocessor-controlled prosthetic knees for limited community ambulators with above-knee amputation.

  This test will see if switching to a microprocessor-controlled prosthetic knee reduces fall-related health problems and improves walking speed, mobility, and quality of life for adults with above-knee amputations who are limited community ambulators compared with non-microprocessor knees.

  Recruiting Hanger Institute for Clinical Research and Education, LLC · Austin, Texas · NCT06937242

• Microprocessor-controlled prosthetic knees for limited community ambulators with above-knee amputation.

  This test will see if switching to a microprocessor-controlled prosthetic knee reduces fall-related health problems and improves walking speed, mobility, and quality of life for adults with above-knee amputations who are limited community ambulators compared with non-microprocessor knees.

  Recruiting Hanger Institute for Clinical Research and Education, LLC · Austin, Texas · NCT06937242

• Tracking nerve-freezing during limb amputation to learn about post-operative and phantom limb pain

  This registry will track how freezing nerves (cryoablation) is used during limb amputations to see if it affects post-operative and phantom limb pain in adults who have or will have an amputation.

  Recruiting at 9 sites AtriCure, Inc. · Jacksonville, Florida and 8 other locations · NCT06908538

• Surgical techniques for treating pain after cancer-related amputations

  This study is testing two different surgical methods to see if they can help cancer patients who have had amputations feel less pain in their residual limbs and reduce phantom limb pain.

  Recruiting M.D. Anderson Cancer Center · Houston, Texas · NCT06840262

• Improving muscle strength and reducing pain in amputees using electrical stimulation

  This study is testing a home-based electrical stimulation program to see if it can help people with a leg amputation build muscle strength and reduce pain.

  Recruiting O&P Clinical Innovations · Pittsburgh, Pennsylvania · NCT06830876

• Assessment of patients with transfemoral amputation using osseointegrated implants

  This study is testing if a new type of implant that attaches directly to the bone can help people with transfemoral amputation move better and feel more comfortable than traditional prosthetic sockets.

  Recruiting Istituto Ortopedico Rizzoli · Bologna, Bologna · NCT06737770

• Improving physical activity for individuals after lower limb amputation

  This study is testing a new virtual program to help people who have had a leg amputation due to diabetes or vascular disease become more active and improve their physical health.

  Recruiting West Park Healthcare Centre · Toronto, Ontario · NCT06667739

• Osseointegrated (bone-anchored) prosthesis for below-knee (transtibial) amputation

  This trial tests whether the OPRA bone-anchored implant helps people aged 22–65 with transtibial (below-knee) amputations who cannot use or do not benefit from socket prostheses.

  Recruiting at 2 sites Walter Reed National Military Medical Center · Bethesda, Maryland and 1 other locations · NCT06636136

• Testing a new prosthesis control method for upper limb amputees

  This study is testing a new way to control prosthetic arms to see if it helps people with upper limb amputations perform better and feel more satisfied compared to a standard method.

  Recruiting Infinite Biomedical Technologies · Redondo Beach, California · NCT06539936

• Point Mini for children with partial hand differences

  This trial will test whether the Point Mini helps children ages 5–15 with partial hand loss use their hands better than their current prosthesis, other assistive device, or no device.

  Recruiting Point Designs · Lafayette, Colorado and 1 other locations · NCT06501092

• Understanding the impact of powered prosthetics on walking for transfemoral amputees

  This study is testing whether powered knee and ankle prosthetics can help transfemoral amputees walk better, especially when combined with special training.

  Recruiting Shirley Ryan AbilityLab · Chicago, Illinois · NCT06433648

• Understanding the impact of powered prosthetics on walking for transfemoral amputees

  This study is testing whether powered knee and ankle prosthetics can help transfemoral amputees walk better, especially when combined with special training.

  Recruiting Shirley Ryan AbilityLab · Chicago, Illinois · NCT06433648

• Improving walking skills for lower limb prosthesis users on uneven terrain

  This study tests a walking program for people using lower limb prostheses to see if training on uneven surfaces helps them walk better and feel more confident.

  Recruiting University of Nevada, Las Vegas · Las Vegas, Nevada · NCT06419920

• Using a Regenerative Peripheral Nerve Interface to Improve Control of Lower Limb Prostheses

  This study is testing whether a new nerve interface can help people with above-knee amputations have better control and feeling in their robotic legs.

  Recruiting University of Michigan · Ann Arbor, Michigan · NCT06275282

• Evaluating a new adaptable foot prosthesis for amputees

  This study is testing a new foot prosthesis that can adjust to different movements to see if it helps people with lower limb amputations walk better and feel more comfortable compared to their usual prosthetic feet.

  Recruiting at 3 sites University of Washington · Tampa, Florida and 2 other locations · NCT06214026

• Registry for patients using lower-limb prosthetics

  This study is collecting information from people using lower-limb prosthetics to see how different devices work for them over time.

  Recruiting Össur Iceland ehf · Irvine, California · NCT06210620

• Comparing powered and mechanical prosthetic knees for K2-level amputees

  This study is testing whether powered prosthetic knees work better than mechanical ones for K2-level amputees to help improve their mobility and make better choices for future prosthetic designs.

  Recruiting Liberating Technologies, Inc. · Austin, Texas · NCT06194838

• Comparing powered and mechanical prosthetic knees for K2-level amputees

  This study is testing whether powered prosthetic knees work better than mechanical ones for K2-level amputees to help improve their mobility and make better choices for future prosthetic designs.

  Recruiting Liberating Technologies, Inc. · Austin, Texas · NCT06194838

• Comparing powered and mechanical prosthetic knees for K2-level amputees

  This study is testing whether powered prosthetic knees work better than mechanical ones for K2-level amputees to help improve their mobility and make better choices for future prosthetic designs.

  Recruiting Liberating Technologies, Inc. · Austin, Texas · NCT06194838

• Reducing phantom limb pain in amputees

  This study is testing two different rehabilitation programs to see which one helps amputees with phantom limb pain feel better.

  Recruiting Neuroscience Research Australia · Randwick, New South Wales · NCT06167330

• Evaluation of a powered prosthesis for individuals with transfemoral amputation

  This study is testing a powered knee and ankle prosthesis to see if it helps people with leg amputations move better and feel more satisfied with their mobility after special surgeries.

  Recruiting Shirley Ryan AbilityLab · Chicago, Illinois · NCT06160882

• Adaptive control of powered prosthetic legs for amputees

  This study is testing a new way to make powered prosthetic legs work better for amputees by adapting to different walking speeds and activities.

  Recruiting University of Michigan · Ann Arbor, Michigan · NCT06138977

• Evaluating the MyoTrain System for Individuals with Trans-radial Limb Loss

  This study is testing if the MyoTrain system can help people who have lost their arm below the elbow learn to use prosthetics better compared to regular training methods.

  Recruiting Infinite Biomedical Technologies · Grand Rapids, Michigan · NCT05888428

• Evaluation of a new myoelectric prosthesis for transradial amputees

  This study is testing a new type of prosthetic arm that uses a special implant to help people with below-the-elbow amputations control it more easily and naturally.

  Recruiting University of Pittsburgh · Pittsburgh, Pennsylvania · NCT05768802

• Evaluation of a new myoelectric prosthesis for transradial amputees

  This study is testing a new type of prosthetic arm that uses a special implant to help people with below-the-elbow amputations control it more easily and naturally.

  Recruiting University of Pittsburgh · Pittsburgh, Pennsylvania · NCT05768802

• Comparing oral and intravenous antibiotics for treating infected nonunion of fractures

  This study is testing whether taking antibiotics by mouth works as well as getting them through an IV for people with infected fractures that haven't healed properly after surgery.

  Recruiting at 9 sites Phase 3 Major Extremity Trauma Research Consortium · Indianapolis, Indiana and 12 other locations · NCT05699174

• Improving footwear options for women Veterans with leg amputations

  This study tests a new ankle-foot prosthetic designed for women Veterans with leg amputations to see if it helps them feel better about themselves and participate more in their communities while wearing different types of shoes.

  Recruiting VA Office of Research and Development · Minneapolis, Minnesota · NCT05601869

• Exploring touch sensations to improve feedback in prosthetics

  This study is testing how touch sensations can be improved in prosthetics to help amputees feel better and interact more naturally with their devices.

  Recruiting Institut National de la Santé Et de la Recherche Médicale, France · Marseille and 1 other locations · NCT05548322

• Using micro-electrodes to control prosthetic limbs and provide sensory feedback for amputees

  This study is testing if tiny electrodes can help amputees control advanced prosthetic arms and feel sensations like touch.

  Recruiting University of Utah · Salt Lake City, Utah · NCT05505513

• Using multi-sensory stimulation to help patients with neuropathy and chronic pain

  This study is testing whether a combination of virtual reality and electrical nerve stimulation can help people with neuropathy and chronic pain feel better.

  Recruiting ETH Zurich · Zurich, Canton of Zurich · NCT05483816

• Evaluating a new prosthesis control system for amputees

  This study is testing a new way for amputees to control a prosthetic hand using special sensors implanted in their arm muscles to see how well it works in everyday life.

  Recruiting Össur Iceland ehf · Glasgow, Glasgow · NCT04936789

• Understanding the experiences of upper limb prosthesis users

  This study is trying to understand how people who use upper limb prostheses feel about them and what affects their acceptance, to help match them with the right devices and improve their quality of life.

  Recruiting Louis Stokes VA Medical Center · Cleveland, Ohio · NCT04855214

• Evaluating fibroblast injections for amputees

  This study is testing if injections made from patients' own skin cells can help improve the healing and comfort of adults with lower leg amputations using prostheses.

  Recruiting Phase 2 Major Extremity Trauma Research Consortium · Baltimore, Maryland · NCT04839497

• Early Psychological and Physiotherapy Follow-up After Lower-Limb Amputation

  We’re testing if adding a psychologist and a physiotherapist before and after surgery helps improve physical and emotional well-being for adults with lower-limb amputations.

  Recruiting Centre Hospitalier Departemental Vendee · La Roche-sur-Yon · NCT04750876

• Using heparin to improve success after finger replantation

  This study is testing if giving heparin through an IV can help improve the chances of success for people who have had their fingers amputated and are getting them reattached.

  Recruiting Phase 4 Centre hospitalier de l'Université de Montréal (CHUM) · Montreal, Quebec · NCT04725201

• Innovative surgery for improving lower limb prosthetics and reducing pain in amputees

  This study is testing a new type of surgery for amputees to see if it can help reduce pain and improve movement by using special devices in their residual limb.

  Recruiting at 2 sites Brigham and Women's Hospital · Bethesda, Maryland and 2 other locations · NCT04063592

• Injection of skin cells from the palm or sole into the stump site of amputees

  This study is testing if injecting skin cells from the palm or sole into the stump of below-the-knee amputees can make the skin healthier and more comfortable.

  Recruiting Phase 2 Johns Hopkins University · Baltimore, Maryland · NCT03947450

• A new method for upper limb amputation to improve control and sensation

  This study is testing a new way to perform upper limb amputations to see if it can help patients control advanced prosthetics better and feel more sensation in their limbs.

  Recruiting at 4 sites Brigham and Women's Hospital · Bethesda, Maryland and 3 other locations · NCT03882073

• Using hyperbaric oxygen therapy after lower limb amputation

  This study is testing if adding hyperbaric oxygen therapy after a leg amputation can help patients heal better and reduce the chances of needing more amputations.

  Recruiting at 2 sites Oslo University Hospital · Oslo and 1 other locations · NCT03594344

• Using nerve feedback to help lower limb amputees feel sensations in their prosthetics

  This study tests whether giving nerve feedback through small electrical currents can help lower limb amputees feel sensations in their prosthetics and control them better.

  Recruiting Louis Stokes VA Medical Center · Cleveland, Ohio · NCT03409133

• Improving prosthetic limb control with implanted electrodes after nerve surgery

  This study is testing if implanted electrodes can help people who have lost an arm control their prosthetic limb better after having surgery to repair their nerves.

  Recruiting University of Michigan · Ann Arbor, Michigan · NCT03260400

• Improving hand control for amputees using advanced electrodes

  This study is testing if special electrodes can improve hand control for people with different types of upper limb amputations.

  Recruiting University of Texas Southwestern Medical Center · Dallas, Texas · NCT02994160

• Penile allotransplantation for men with severe penile injuries

  This study is testing a new surgery to see if transplanting a penis can help men who have lost theirs due to serious injuries or cancer feel better and improve their quality of life.

  Recruiting Phase 2/3 Johns Hopkins University · Baltimore, Maryland · NCT02395497

NIH-funded research (28)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Spinal muscle targets to improve mobility after leg amputation

  A study with adults who’ve had a lower-leg amputation will look at how spinal muscle weakness and fat in the back muscles relate to mobility, with the aim of guiding rehabilitation choices.

  NIH research University of Delaware · Newark, UNITED STATES · NIH-11599315

• Bone and skin movement inside prosthetic sockets for below-knee amputees

  This project uses moving X-ray and CT-based 3D models to measure how bones, skin, and liners move inside the prosthetic socket of people with below-knee amputations during walking and other activities.

  NIH research VA Medical Center · New York, United States · NIH-11457775

• Surgical strategies to prevent and reduce amputation pain

  This project tests how two nerve-sparing techniques can prevent or lessen phantom and residual limb pain in people who have or will have amputations, especially veterans.

  NIH research Clement J. Zablocki VA Medical Center · Milwaukee, United States · NIH-11412844

• Improving how we measure physical function for people using artificial arms

  Aimed at making it easier and more accurate to track how well people with upper limb prostheses move and function in daily life.

  NIH research Providence VA Medical Center · Providence, United States · NIH-11402390

• AMPDECIDE: Helping Veterans choose amputation level with personalized outcome information

  A doctor helps a veteran facing leg amputation learn personalized risks and likely outcomes for different amputation levels to guide their care choices.

  NIH research VA Puget Sound Healthcare System · Seattle, United States · NIH-11395975

• Thermoregulation and tissue health in leg-amputee patients

  This grant looks at how skin temperature and mechanical factors during walking affect tissue health and risk of sores in people with a leg amputation, especially those with diabetes.

  NIH research Utah State Higher Education System--University of Utah · Salt Lake City, United States · NIH-11372931

• Biomechanical changes in the shoulder after losing a forearm through amputation

  Researchers will study how losing a forearm affects shoulder movement and bone shape in people with transhumeral amputation, compared to healthy individuals.

  NIH research Utah State Higher Education System--University of Utah · Salt Lake City, United States · NIH-11359594

• Prevention of Amputation with Rapid Healing of Diabetic Ulcers Using a Patient's Own Fat

  A new, quick, point-of-care treatment using a patient’s own fat tissue aims to speed healing of foot ulcers in adults with diabetes to prevent amputation.

  NIH research Syntr Health Technologies, LLC · Irvine, UNITED STATES · NIH-11349024

• Automatically adjusting socket for below-knee prostheses

  A prosthetic socket that automatically changes size to keep a comfortable, stable fit for people with below-knee (transtibial) amputations.

  NIH research University of Washington · Seattle, United States · NIH-11320787

• Targeted spinal-cord electrodes to restore feeling after lower-limb amputation

  This project is designing and testing thinner, more flexible spinal-cord electrodes to create focused sensations for people with lower-limb amputations.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11314502

• Preventing amputations in rural patients with diabetes and poor circulation

  This study is working on a friendly program to help people in rural West Virginia with diabetes and circulation problems avoid amputations by creating community-based solutions that fit their needs.

  NIH research Duke University · Durham, United States · NIH-11294631

• Chronic Post-amputation Pain: Identifying Risk Factors to Improve Care

  A study of people who have had an amputation to learn what factors before, during, and after surgery are linked to chronic pain, with the goal of guiding better care.

  NIH research VA Boston Health Care System · Boston, United States · NIH-11290794

• Improving walking for Veterans with non‑traumatic leg amputation

  A rehabilitation program aims to help Veterans with non‑traumatic lower‑limb amputation walk more evenly and reduce disability.

  NIH research VA Eastern Colorado Health Care System · Aurora, UNITED STATES · NIH-11249121

• A modified below-knee amputation to help veterans with diabetes or poor leg circulation walk and have less pain

  Testing a modified below-knee amputation called the Ewing amputation in veterans with diabetes or peripheral arterial disease to improve walking with a prosthesis and reduce pain.

  NIH research Cincinnati VA Medical Center Research · Cincinnati, United States · NIH-11222664

• Better ways to measure arm and hand function after an upper limb amputation

  This project is improving questionnaires and short performance tests to more accurately track how people with upper limb amputations use prosthetic arms and hands.

  NIH research Providence VA Medical Center · Providence, United States · NIH-11220692

• Decision aids to help Veterans choose the best amputation level

  This project will build easy-to-use tools that show Veterans their personalized chances of outcomes for different lower-leg amputation levels so they can choose what fits their goals.

  NIH research VA Puget Sound Healthcare System · Seattle, United States · NIH-11206915

• Understanding Temperature Control in People with Leg Amputations

  This project looks at how body temperature is regulated in people with a leg amputation to help prevent skin problems like pressure sores.

  NIH research Utah State Higher Education System--University of Utah · Salt Lake City, United States · NIH-11136337

• A prosthetic socket that automatically adjusts for amputees

  This study is testing a new type of prosthetic socket for people with below-the-knee amputations that automatically adjusts to fit comfortably while they walk or sit, making it easier for them to stay active and enjoy life without constantly worrying about their fit.

  NIH research University of Washington · Seattle, United States · NIH-11061891

• Understanding the causes of chronic pain after amputation

  This study is looking into what causes ongoing pain after an amputation, focusing on things like medical care, genetics, and emotional factors, to help improve treatment for amputees who experience this kind of pain.

  NIH research VA Boston Health Care System · Boston, United States · NIH-11061789

• Measuring bone and skin movement in prosthetic limbs for amputees

  This study looks at how the part of the leg left after a below-the-knee amputation moves with the prosthetic socket during activities, using special imaging technology to help make prosthetics more comfortable and effective for people like you.

  NIH research VA Medical Center · New York, United States · NIH-11055337

• Using electrodes to stimulate the spinal cord for restoring sensation in amputees

  This study is working on creating better electrodes that can help people with lower-limb amputations feel sensations in their missing leg, which could make it easier for them to balance and move around safely.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11046662

• Improving how we measure grief after limb amputation to enhance health outcomes.

  This study is looking at how people feel emotionally after losing a limb and aims to create better ways to understand and support those feelings, so that healthcare providers can help patients heal both physically and emotionally.

  NIH research University of Washington · Seattle, United States · NIH-11032395

• Helping Veterans make informed decisions about amputation levels

  This study is all about helping Veterans who have had leg amputations because of diabetes or circulation issues by giving them personalized information to help them make the best choices for their health and lifestyle, so they can feel more in control and improve their quality of life.

  NIH research VA Puget Sound Healthcare System · Seattle, United States · NIH-10994031

• Improving walking ability for veterans with non-traumatic lower limb amputation

  This study is looking to help veterans with non-traumatic lower limb amputations, like those caused by diabetes, walk more evenly and comfortably, so they can enjoy a better quality of life and avoid further health problems.

  NIH research VA Eastern Colorado Health Care System · Aurora, UNITED STATES · NIH-10988225

• Developing a new prosthetic finger for people with partial hand loss

  This study is working on a new, easy-to-use prosthetic finger for people who have lost part of their hand, aiming to make everyday tasks easier and improve their quality of life.

  NIH research Point Designs, LLC · Broomfield, UNITED STATES · NIH-10931733

• Improving how we measure physical function in people with upper limb amputations

  This study is all about improving how we measure how well upper limb prostheses help people with arm amputations, so we can better understand their daily function and make sure they’re getting the support they need.

  NIH research Providence VA Medical Center · Providence, United States · NIH-10923928

• Investigating a new amputation technique for veterans with peripheral arterial disease

  This study is looking at a new type of surgery called Ewing amputation for veterans with diabetes and peripheral arterial disease who need below-knee amputations, to see if it helps them recover better and walk more easily with prosthetics.

  NIH research Veterans Health Administration · Decatur, UNITED STATES · NIH-10919765

• Understanding temperature regulation in people with a leg amputation to prevent tissue complications

  This study looks at how temperature changes in the legs of people with a leg amputation can affect their skin health, especially for those with diabetes, to help find better ways to prevent issues like pressure sores.

  NIH research University of Utah · Salt Lake City, United States · NIH-10886611

Related topics

Quick answers

How many Amputation clinical trials are recruiting right now?

62, as of November 12, 2026. 2 of them were first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 12 countries. The most sites are in United States (47 trials), France (4 trials), Canada (2 trials), Italy (1 trial), United Kingdom (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 2, Phase 4: 1, Phase 2/3: 1, Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

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