Chronic Post-amputation Pain: Identifying Risk Factors to Improve Care
Official title: Identification of Procedural, Genetic and Psychosocial Risk Factors for ChronicPost-Amputation Pain
Funded at VA Boston Health Care System · NIH-11290794 · Data updated 2026-11-12
A study of people who have had an amputation to learn what factors before, during, and after surgery are linked to chronic pain, with the goal of guiding better care.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | VA Boston Health Care System NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | April 1, 2024 |
| Project end | March 31, 2028 |
| Funding year | 2027 |
| NIH project number | 5I01BX006104-03 |
| Project ID | NIH-11290794 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults who have undergone amputation and are part of the MVP Amputee cohort, including Veterans receiving care at VA facilities.
✕Less likely to help
Patients without access to MVP or VA healthcare data may have limited direct applicability to their care.
What this research studies
This project uses data from the Million Veteran Program to look at people who have had an amputation and track how many develop chronic post-amputation pain (cPAP), when it appears, and how severe it is over time. It will also examine the surgeries and post-operative care they received and whether these practices influence cPAP development. The aim is to uncover demographic, genetic, procedural, and psychosocial risk factors so clinicians can tailor prevention and treatment strategies. The work will provide a clearer picture of cPAP in a real-world veteran population and identify potential targets for intervention.
Why it matters
Potential benefit: If successful, findings could help doctors predict who is at risk for cPAP and guide earlier, more effective prevention and treatment strategies.
How similar studies have gone: Previous work has shown that post-amputation pain is common and multifactorial, but this study aims to expand understanding using MVP data.
Where this research is happening
-
VA Boston Health Care System
Boston, United States Active
Researchers
- Principal investigator: Otis, John D — VA Boston Health Care System
- Study coordinator: Otis, John D
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.