Understanding temperature regulation in people with a leg amputation to prevent tissue complications
Official title: Thermoregulation in individuals with a leg amputation: mechanics and vascular physiology factors to understand risks for tissue complications
Funded at University of Utah · NIH-10886611 · Data updated 2026-11-12
This study looks at how temperature changes in the legs of people with a leg amputation can affect their skin health, especially for those with diabetes, to help find better ways to prevent issues like pressure sores.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project start | August 26, 2022 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $453,177 |
| NIH project number | 5R01HD106911-03 |
| Project ID | NIH-10886611 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals aged 21 and older who have undergone a unilateral leg amputation, particularly those with diabetes.
✕Less likely to help
Patients who have not experienced a leg amputation or those under 21 years old may not benefit from this research.
What this research studies
This research investigates how temperature regulation affects individuals with a leg amputation, focusing on the intact leg and residual limb. It aims to understand the mechanical and vascular factors that contribute to skin temperature changes, which can lead to complications like pressure sores. By studying how these factors interact, especially in patients with diabetes, the research seeks to identify risks and improve early diagnosis and intervention strategies. The methodology includes monitoring temperature responses during walking and analyzing the impact of mechanical forces on tissue health.
Why it matters
Potential benefit: If successful, this research could lead to better prevention strategies for tissue complications in amputees, enhancing their quality of life.
How similar studies have gone: Previous studies have shown promising results in understanding temperature regulation in similar populations, indicating that this approach may yield valuable insights.
Where this research is happening
-
University of Utah
Salt Lake City, United States Active
Researchers
- Principal investigator: Takahashi, Kota — University of Utah
- Study coordinator: Takahashi, Kota
Related research
Other NIH-funded projects on the same topics.
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Spinal muscle targets to improve mobility after leg amputation
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AMPDECIDE: Helping Veterans choose amputation level with personalized outcome information
A doctor helps a veteran facing leg amputation learn personalized risks and likely outcomes for different amputation levels to guide their care choices.
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Thermoregulation and tissue health in leg-amputee patients
This grant looks at how skin temperature and mechanical factors during walking affect tissue health and risk of sores in people with a leg amputation, especially those with diabetes.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.