Understanding the causes of chronic pain after amputation
Official title: Identification of Procedural, Genetic and Psychosocial Risk Factors for ChronicPost-Amputation Pain
Funded at VA Boston Health Care System · NIH-11061789 · Data updated 2026-11-12
This study is looking into what causes ongoing pain after an amputation, focusing on things like medical care, genetics, and emotional factors, to help improve treatment for amputees who experience this kind of pain.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | VA Boston Health Care System NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | April 1, 2024 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| NIH project number | 5I01BX006104-02 |
| Project ID | NIH-11061789 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have undergone an amputation and are experiencing or at risk of chronic post-amputation pain.
✕Less likely to help
Patients who have not undergone amputation or those who do not experience chronic pain after amputation may not benefit from this research.
What this research studies
This research investigates the factors contributing to chronic post-amputation pain (cPAP) among amputees, focusing on procedural, genetic, and psychosocial elements. By analyzing data from the Million Veteran Program, the study aims to identify the demographics of amputees and the incidence of cPAP, as well as the impact of perioperative care and access to treatment on pain outcomes. The goal is to fill critical knowledge gaps regarding cPAP and improve future treatment options for affected patients.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and management of chronic pain in amputees, ultimately improving their quality of life.
How similar studies have gone: Previous research has shown that understanding the multifactorial nature of chronic pain can lead to improved treatment strategies, suggesting this approach has potential for success.
Where this research is happening
-
VA Boston Health Care System
Boston, United States Active
Researchers
- Principal investigator: Otis, John D — VA Boston Health Care System
- Study coordinator: Otis, John D
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.