Reducing phantom limb pain in amputees

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the effectiveness of two rehabilitation programs for individuals with amputations experiencing phantom limb pain. Participants will be randomized into two groups: one receiving a progressive rehabilitation program that includes pain science education, sensory training, and mirror therapy, and the other receiving treatment with transcutaneous electrical nerve stimulation and cranial electrical stimulation. The study aims to determine which approach is more effective in reducing pain intensity and interference. A total of 208 participants will be involved in this research.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Experiencing phantom limb pain for at least three months.
* Report at least one episode of phantom limb pain in the previous week.
* Report at least 4 points in pain intensity over the previous 7 days, assessed using the 11-point Numerical Pain Rating Scale.
* Be a resident in Australia for the intervention and follow-up period.
* Have access to the internet and smart device (e.g., mobile phone).
* Be proficient in English.

Exclusion Criteria:

* Bilateral amputation.
* Scheduled for major surgery during the study period.
* Pain in the intact limb.
* Vision impairment that would preclude successful participation.
* Auditory impairment that would preclude successful participation.
* Cognitive problems that would preclude effective participation in trial procedures (e.g., Alzheimer's, dementia).
* Previously diagnosed neurological disorders that affect the movement of the intact limb (e.g., stroke, Parkinson, Multiple Sclerosis).
* Completed Graded Motor Imagery in the order of left/right judgements, imagined movements, and mirror therapy.
* Have contraindications for the use of stimulation devices (e.g., pacemaker, spinal cord stimulator).

Where it's running

• Neuroscience Research Australia
  Randwick, New South Wales, Australia Recruiting

Study contacts

• Principal investigator: James H McAuley, PhD — Neuroscience Research Australia
• Study coordinator: James H McAuley, PhD
• Email: j.mcauley@neura.edu.au
• Phone: +61293991266

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.