Condition

Metastatic Cancer clinical trials and research

• 74Clinical trials
• 19NIH research projects
• 33Countries

Newest Metastatic Cancer clinical trials

All recruiting trials (74)

• IL-15–Enhanced NK Cell Therapy for Solid Tumors

  A first-in-human, early-phase study tests whether IL-15–enhanced engineered NK cells are safe and can show early signs of effect in adults with relapsed or metastatic solid tumors.

  Recruiting Early Phase 1 Genovn Therapeutics PTE. LTD. · Chongqing · NCT07621471

• LATTICE radiotherapy vs moderately dose-escalated palliative radiation for metastases

  This study tests whether LATTICE radiotherapy given in 5 fractions works better than a standard palliative dose for patients with metastatic cancer who have 1–2 sizable tumors.

  Recruiting Phase 2 Stanford University · Palo Alto, California · NCT07594431

• Givastomig with nivolumab and chemotherapy for CLDN18.2-positive metastatic stomach or gastroesophageal junction cancer

  This study will see if adding givastomig to nivolumab plus standard chemotherapy helps adults with CLDN18.2- and PD-L1-positive metastatic stomach or gastroesophageal junction cancer live longer without their disease getting worse.

  Recruiting at 5 sites Phase 2 I-Mab Biopharma US Limited · Goodyear, Arizona and 5 other locations · NCT07432295

• Support program for parents living with advanced cancer

  This study tests whether adding experiential sessions to a psycho-educational program helps parents with advanced cancer communicate better with their children aged 10–25.

  Recruiting Université Libre de Bruxelles · Anderlecht · NCT07341815

• POLARIS — Ablative radiotherapy with immunotherapy for people with multiple metastatic lesions

  This pilot tests whether giving focused high-dose radiation to up to 10 metastatic tumors while patients are on immunotherapy helps people with advanced solid tumors who have 3–10 metastases.

  Recruiting Phase 1 University of Illinois Chicago · Chicago, Illinois · NCT07269080

• Adding Y‑NM600 imaging and targeted Y‑90 radiation to anti‑PD‑1/PD‑L1 treatment for metastatic cancer

  This will test whether giving radioactive Y‑NM600 imaging and a targeted Y‑90 radiation dose to people with metastatic cancer who are on anti‑PD‑1 or anti‑PD‑L1 medicines is safe and can help those medicines work better.

  Recruiting Phase 1 University of Wisconsin, Madison · Madison, Wisconsin · NCT07197671

• 68Ga-FXX489 PET/CT to image tumor stroma and metastases

  This test will try a new PET/CT radiotracer called 68Ga-FXX489 in adults with suspected or confirmed solid tumors to see if it safely lights up tumors and metastatic disease.

  Recruiting Phase 1 First Hospital of China Medical University · Shenyang, Liaoning · NCT07144085

• Zanzalintinib with a bone-strengthening agent for metastatic clear cell RCC with bone metastases

  This phase 2 trial tests zanzalintinib plus a bone-strengthening agent in adults with metastatic clear cell renal cell cancer that has spread to bone and progressed after 1–3 prior therapies, including IO therapy.

  Recruiting Phase 2 University of California, San Francisco · San Francisco, California · NCT07043608

• Monthly digital financial hardship screening for people with advanced cancer

  This project tests whether monthly remote digital financial hardship screening helps adults with advanced or metastatic cancer who are receiving non-curative systemic therapy.

  Recruiting at 7 sites Alliance Foundation Trials, LLC. · Phoenix, Arizona and 6 other locations · NCT06963723

• Precision oncology navigation with expert genomic review to guide therapy and survival

  This tests whether a centralized precision oncology navigator and expert review of NGS results increase the use of genome-informed therapies for people with stage IV breast, lung, colorectal, or bladder cancer.

  Recruiting UNC Lineberger Comprehensive Cancer Center · Chapel Hill, North Carolina · NCT06896162

• PET imaging with [68Ga]Ga-ABY-025 to visualize HER2-positive and HER2-low tumors during HER2 therapy

  This trial will test whether a PET tracer called [68Ga]Ga-ABY-025 can better visualize tumors in adults with HER2-positive or HER2-low advanced cancers who are receiving HER2-targeted therapy.

  Recruiting Early Phase 1 Vanderbilt-Ingram Cancer Center · Nashville, Tennessee · NCT06828588

• Treatment of advanced cancers using CEA-targeted CAR-T cells

  This study is testing a new type of CAR-T cell treatment for people with advanced cancers that have a specific marker, to see if it is safe and how well it works for those who haven't had success with other treatments.

  Recruiting Phase 1 Zhejiang University · Hangzhou, Zhejiang · NCT06821048

• Treatment of metastatic solid tumors with SLV-154

  This study is testing a new treatment called SLV-154 for people with advanced solid tumors, like certain types of lung and breast cancer, to see how safe it is and how well it works.

  Recruiting at 12 sites Phase 1 Solve Therapeutics · Newport Beach, California and 11 other locations · NCT06771219

• Program for early detection and management of side effects in metastatic cancer patients

  This study tests a smartphone program that helps people with metastatic cancer spot and manage side effects from their treatment early on to see if it reduces the chances of stopping therapy due to these issues.

  Recruiting M.D. Anderson Cancer Center · Houston, Texas · NCT06693687

• Evaluating PSA response in metastatic prostate cancer

  This study is testing how changes in PSA levels can help doctors understand how well treatments are working for men with advanced prostate cancer.

  Recruiting Fondazione Policlinico Universitario Agostino Gemelli IRCCS · Rome, Lazio · NCT06652607

• Boosting checkpoint immunotherapy with focused ultrasound histotripsy for metastatic or unresectable cancer

  This trial will test whether a single session of focused ultrasound histotripsy combined with ipilimumab and nivolumab helps adults with metastatic or unresectable cancer that has progressed after standard treatments.

  Recruiting Phase 1 UMC Utrecht · Utrecht, Utrecht · NCT06524570

• Lattice radiation therapy for treating large tumors

  This study is testing a new type of radiation therapy called lattice radiation therapy to see if it works better than standard treatment for people with large tumors.

  Recruiting Phase 2 University of Cincinnati · Cincinnati, Ohio · NCT06416007

• Targeted approach for detecting and treating metastatic cancer

  This study is testing a new way to find and treat metastatic cancer using special imaging and a targeted treatment to see if it helps patients who haven't responded to other therapies.

  Recruiting Phase 1 University of California, Davis · Sacramento, California · NCT06389123

• Using targeted stereotactic radiotherapy to try to restore immunotherapy response in metastatic cancer

  This will try three focused stereotactic radiotherapy sessions (8 Gy each on days 1, 4, and 7) to see if that can restore response to anti‑PD‑1 immunotherapy in people with metastatic solid tumors who began to progress after at least six months on immunotherapy.

  Recruiting Elsan · Soyaux, Charente · NCT06363773

• Combining two immunotherapy drugs for MSI-H/dMMR advanced stomach and gastroesophageal junction cancer

  This trial will try two immunotherapy drugs (balstilimab and botensilimab) as first treatment for adults with MSI‑H/dMMR, HER2‑negative advanced or metastatic stomach or gastroesophageal‑junction cancer whose tumors have PD‑L1 CPS ≥5, and will compare that to standard chemotherapy with nivolumab.

  Recruiting at 7 sites Phase 3 Centre Leon Berard · Brest and 6 other locations · NCT06346197

• Registry for patients with metastatic cancer receiving radiation therapy

  This study collects information from patients with metastatic cancer who are getting radiation therapy to see how well it works and improve future treatments.

  Recruiting UNC Lineberger Comprehensive Cancer Center · Chapel Hill, North Carolina · NCT06306924

• Upfront dose-reduced chemotherapy for older patients with metastatic colorectal cancer

  This study is testing whether giving lower doses of chemotherapy can help older patients with advanced colorectal cancer live longer and feel better compared to the standard full doses.

  Recruiting at 10 sites Phase 3 Leiden University Medical Center · 's-Hertogenbosch and 35 other locations · NCT06275958

• Testing MGC026 in patients with advanced solid tumors

  This study is testing a new treatment called MGC026 to see if it can help adults with advanced solid tumors that can't be removed or have spread to other parts of the body.

  Recruiting at 12 sites Phase 1 MacroGenics · Los Angeles, California and 11 other locations · NCT06242470

• Comparing single-isocenter and multiple-isocenter SBRT for treating multiple metastatic cancers

  This study is testing if a simpler radiation treatment for multiple cancers works just as well as a more complex approach to see if it can make things easier and more comfortable for patients.

  Recruiting University of Zurich · Zurich · NCT06230666

• CD70-targeted CAR-T treatment for advanced gynecologic cancer

  This study is testing a new CAR-T treatment that targets CD70 to see if it can help people with advanced gynecologic cancers feel better and improve their outcomes.

  Recruiting Phase 1 Chongqing Precision Biotech Co., Ltd · Wuhu, Anhui · NCT06215950

• Testing PTX-912 in patients with advanced solid tumors

  This study is testing a new drug called PTX-912 to see if it is safe and effective for people with advanced solid tumors.

  Recruiting at 3 sites Phase 1 Proviva Therapeutics, Inc. · Duarte, California and 2 other locations · NCT06190886

• Testing a new treatment for advanced cancer using a radiolabeled drug

  This study is testing a new drug for adults with advanced cancer who have run out of other treatment options to see if it is safe and how well it works.

  Recruiting at 2 sites Phase 1/2 Spago Nanomedical AB · Adelaide, South Australia and 1 other locations · NCT06184035

• Continued access to treatment for patients with advanced cancer

  This study is testing if patients with advanced cancer who have benefited from previous treatments can safely continue receiving a specific drug to see if it helps them longer.

  Recruiting Phase 3 Daiichi Sankyo · Miami, Florida and 33 other locations · NCT06174987

• Radiation treatment for high-risk spine cancer patients

  This study is testing a new type of radiation treatment for patients with cancer that has spread to the spine to see if it can help manage their condition without needing major surgery.

  Recruiting Phase 2 Stony Brook University · Stony Brook, New York · NCT06165419

• Testing XON7 for advanced metastatic solid tumors

  This study is testing a new treatment called XON7 to see if it can help people with advanced solid tumors that haven't responded to other therapies.

  Recruiting at 5 sites Phase 1/2 Xenothera SAS · Anderlecht and 4 other locations · NCT06154291

• Treatment for Oligometastatic Breast Cancer

  This study is testing whether adding a special type of radiation therapy to standard treatment can help women with a few metastatic breast cancer spots live longer and feel better.

  Recruiting National Cancer Institute, Egypt · Cairo · NCT06144346

• Combining radiotherapy and immunotherapy for limited metastatic gastric cancer

  This study is testing a new treatment that combines radiation, chemotherapy, and immunotherapy to see if it can help people with limited metastatic gastric cancer live longer and improve their health.

  Recruiting Phase 2 Fudan University · Shanghai · NCT06121700

• Monoclonal antibody treatment for advanced solid tumors

  This study is testing a new antibody treatment for people with advanced solid tumors to see if it is safe and effective on its own or when combined with another cancer drug.

  Recruiting at 4 sites Phase 1/2 OncoResponse, Inc. · Austin, Texas and 3 other locations · NCT06090266

• Evaluating disparities in precision oncology for metastatic cancer patients

  This study looks at how different social factors affect the treatment and outcomes for people with metastatic cancer to help understand why some patients do better than others.

  Recruiting Indiana University · Indianapolis, Indiana · NCT06081517

• Identifying biomarkers for endocrine therapy resistance in lobular breast cancer

  This study is trying to find markers in the blood that can help doctors understand how well patients with lobular breast cancer respond to hormone therapy.

  Recruiting Phase 2 University of Wisconsin, Madison · Madison, Wisconsin · NCT06067503

• Using Trastuzumab Deruxtecan to treat brain cancer

  This study is testing if a new drug called trastuzumab deruxtecan can effectively treat brain cancer in adults with specific types of tumors that have the HER2 protein.

  Recruiting Phase 2 Memorial Sloan Kettering Cancer Center · New York, New York · NCT06058988

• Testing ONM-501 alone and with Cemiplimab for advanced solid tumors and lymphomas

  This study is testing a new treatment called ONM-501, both alone and with another drug called cemiplimab, to see if it can help people with advanced solid tumors and lymphomas who have run out of other treatment options.

  Recruiting at 5 sites Phase 1 OncoNano Medicine, Inc. · Los Angeles, California and 15 other locations · NCT06022029

• FOG-001 treatment for advanced or metastatic solid tumors

  This study is testing a new drug called FOG-001 to see if it can help people with advanced solid tumors, especially those with certain genetic changes, when traditional treatments aren't working.

  Recruiting at 32 sites Phase 1/2 Parabilis Medicines, Inc. · Phoenix, Arizona and 32 other locations · NCT05919264

• Evaluating CJRB-101 with Pembrolizumab for Advanced Cancer

  This study is testing a new treatment combining CJRB-101 with pembrolizumab to see if it helps people with advanced cancers like lung cancer and melanoma feel better and respond better to their treatment.

  Recruiting at 4 sites Phase 1/2 CJ Bioscience, Inc. · Irvine, California and 3 other locations · NCT05877430

• Platform program for evaluating treatments in metastatic HER2-positive breast cancer

  This study is testing different new treatments for people with advanced HER2-positive breast cancer to see which ones work best before moving them to larger trials.

  Recruiting at 5 sites Phase 1/2 QuantumLeap Healthcare Collaborative · Birmingham, Alabama and 9 other locations · NCT05868226

• MQ710 with or without pembrolizumab for advanced skin and other solid tumors

  This will test different doses of MQ710, alone or together with pembrolizumab, in adults with advanced or recurrent solid tumors (including skin cancers) to find a safe dose with mild side effects.

  Recruiting at 5 sites Phase 1 Memorial Sloan Kettering Cancer Center · Basking Ridge, New Jersey and 6 other locations · NCT05859074

• Comparing surgical methods for metastatic pathologic fractures

  This study is testing which of three surgical methods works best to help people with painful fractures caused by cancer so they can feel better and move around more easily.

  Recruiting Ankara University · Ankara, altindag · NCT05825456

• Evaluating INX-315 for advanced cancer treatment

  This study is testing a new oral medication called INX-315 to see if it can safely help people with advanced cancers, including breast and ovarian cancer, who haven't responded to other treatments.

  Recruiting at 17 sites Phase 1/2 Incyclix Bio · Orlando, Florida and 17 other locations · NCT05735080

• Evaluating liver embolization techniques for tumor management

  This study tests different liver embolization methods to see how well they help people with liver tumors live longer and maintain liver function while they continue their usual treatments.

  Recruiting IRCCS San Raffaele · Milan · NCT05714124

• Immunotherapy using E7 TCR-T cells for HPV-related cancers

  This study is testing a new immunotherapy using E7 TCR-T cells to see if it can help people with advanced HPV-related cancers like cervical and throat cancer feel better and improve their health.

  Recruiting at 3 sites Phase 2 Rutgers, The State University of New Jersey · Bethesda, Maryland and 2 other locations · NCT05686226

• Immunotherapy for advanced metastatic solid tumors

  This study is testing a new immunotherapy called SYNC-T to see if it can help people with advanced solid tumors that haven't responded to other treatments.

  Recruiting Phase 1 Williams Cancer Foundation · Mexico City · NCT05544240

• Ablative radiotherapy for metastatic cancer treatment

  This study is testing if a new type of targeted radiation therapy can help people with multiple metastatic cancers live longer and feel better compared to standard treatment.

  Recruiting at 3 sites London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's · London, Ontario and 2 other locations · NCT05508464

• Using immunotherapy to treat advanced cervical cancer

  This study is testing a new immunotherapy called MGD019 to see if it can help people with advanced cervical cancer who haven't had chemotherapy yet.

  Recruiting Phase 2 M.D. Anderson Cancer Center · Houston, Texas · NCT05475171

• Abiraterone, Enzalutamide, or Apalutamide in Castration-sensitive Prostate Cancer

  This study tests whether adding abiraterone, enzalutamide, or apalutamide helps men with castration-sensitive metastatic prostate cancer.

  Recruiting at 12 sites Phase 2 Sun Pharmaceutical Industries Limited · Los Angeles, California and 11 other locations · NCT05422911

• New treatment for advanced solid tumors using Q901 and pembrolizumab

  This study is testing a new drug called Q901, alone or with pembrolizumab, to see if it can safely help people with advanced solid tumors.

  Recruiting at 14 sites Phase 1/2 Qurient Co., Ltd. · Phoenix, Arizona and 13 other locations · NCT05394103

• Treatment for recurrent prostate cancer with metastases

  This study is testing whether combining hormone therapy with targeted radiation or surgery can help men with recurrent prostate cancer live longer without their cancer spreading.

  Recruiting Phase 3 Universitaire Ziekenhuizen KU Leuven · Leuven · NCT05352178

• Digital health coaching for cancer survivors

  This study is testing whether a digital health coaching program can help cancer survivors feel better and improve their health after finishing treatment.

  Recruiting at 2 sites Pack Health · Gainesville, Florida and 6 other locations · NCT05349227

• Continuing systemic therapy after local treatment for metastatic breast cancer

  This study is testing if continuing treatment after local therapies can help people with metastatic breast cancer feel better and live longer.

  Recruiting at 7 sites Phase 2 The Netherlands Cancer Institute · Alkmaar and 6 other locations · NCT05301881

• Infusion of engineered lymphocytes for patients with NY-ESO-1 expressing metastatic cancers

  This study is testing a new treatment using specially modified immune cells to see if it can help people with certain advanced cancers that have the NY-ESO-1 marker.

  Recruiting Phase 1/2 Hadassah Medical Organization · Jerusalem · NCT05296564

• Using liquid biopsy to improve cancer treatment in community hospitals

  This study is testing if using a simple blood test can help doctors make better treatment choices for people with advanced cancer at community hospitals.

  Recruiting at 13 sites Gustave Roussy, Cancer Campus, Grand Paris · Bayonne and 20 other locations · NCT05283044

• Monoclonal antibody treatment for advanced cancer

  This study is testing a new antibody treatment for people with advanced cancer to see if it is safe and effective, either on its own or with another medication.

  Recruiting at 17 sites Phase 1/2 Aulos Bioscience, Inc. · Miami, Florida and 16 other locations · NCT05267626

• Combination treatment of Penpulimab and Cetuximab for advanced head and neck cancer

  This study is testing a new combination of two medications, Penpulimab and Cetuximab, to see if they can help people with advanced head and neck cancer who haven't had treatment before.

  Recruiting at 2 sites Phase 2 Eye & ENT Hospital of Fudan University · Changchun, Jilin and 1 other locations · NCT05260671

• Evaluating liquid biopsy as a diagnostic tool for metastatic cancer

  This study tests whether a simple blood test can help diagnose metastatic cancer and see how it compares to traditional methods like tissue biopsies.

  Recruiting University Hospital Augsburg · Augsburg, Bavaria · NCT05245136

• (Peak) CGT9486 plus Sunitinib vs Sunitinib in advanced or metastatic GIST

  This study tests whether adding CGT9486 to sunitinib helps people with advanced or metastatic GIST who have already tried other treatments.

  Recruiting at 8 sites Phase 3 Cogent Biosciences, Inc. · Birmingham, Alabama and 125 other locations · NCT05208047

• Treatment of advanced cancer using a targeted radioactive antibody

  This study is testing a new radioactive treatment for advanced colorectal cancer to see how safe it is and what the best dose is for patients.

  Recruiting Phase 1 City of Hope Medical Center · Duarte, California · NCT05204147

• Validation of a survival prediction tool for metastatic cancer patients receiving palliative radiation

  This study is testing a new tool that helps doctors predict how long patients with advanced cancer might live after receiving palliative radiation treatment.

  Recruiting at 3 sites Indiana University · Avon, Indiana and 2 other locations · NCT05100342

• Oncolytic virus treatment combined with nivolumab for advanced solid tumors

  This study is testing a new virus treatment combined with an existing cancer drug to see if it can help people with advanced solid tumors, like lung cancer, whose cancer has not improved with previous treatments.

  Recruiting Phase 1 Memgen, Inc. · Tampa, Florida and 1 other locations · NCT05076760

• Testing lower doses of radiation for metastatic tumors with ATM mutations

  This study is testing whether lower doses of radiation can effectively treat metastatic tumors with ATM mutations in patients who need palliative care.

  Recruiting at 7 sites Phase 2 Memorial Sloan Kettering Cancer Center · Basking Ridge, New Jersey and 6 other locations · NCT05010031

• Stereotactic radiotherapy for patients with metastatic head and neck cancer showing limited progression

  This study is testing if a special type of targeted radiation therapy can help people with metastatic head and neck cancer who are seeing limited disease progression while on other treatments.

  Recruiting Phase 2 Centre hospitalier de l'Université de Montréal (CHUM) · Montreal, Quebec · NCT04989725

• Monitoring side effects of radiotherapy in metastatic cancer patients using wearable technology

  This study is testing if a wearable device can help track vital signs and activity levels in patients with metastatic cancer undergoing radiotherapy to better manage side effects and improve their care.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT04983199

• Evaluating TJ033721 for advanced or metastatic solid tumors

  This study is testing a new drug called TJ033721 to see if it can help people with advanced or metastatic solid tumors, both on its own and in combination with other treatments.

  Recruiting at 7 sites Phase 1 I-Mab Biopharma US Limited · Orange, California and 20 other locations · NCT04900818

• Optimizing treatment selection for advanced colorectal cancer

  This study tests if using blood tests to check for tumor DNA can help doctors choose better chemotherapy options for people with advanced colorectal cancer after their initial treatment.

  Recruiting at 2 sites Phase 2 Aarhus University Hospital · Aarhus N and 1 other locations · NCT04680260

• Treatment of advanced or metastatic solid tumors with ART0380

  This study is testing a new drug called ART0380 to see if it can safely help people with advanced solid tumors that have specific DNA repair issues, either on its own or with other chemotherapy drugs.

  Recruiting at 62 sites Phase 1/2 Artios Pharma Ltd · Birmingham, Alabama and 87 other locations · NCT04657068

• Imaging solid tumors with a new radiolabeled agent

  This study is testing a new imaging agent to see if it can better detect metastatic cancer in patients with solid tumors compared to standard imaging methods.

  Recruiting Phase 1 University of California, San Francisco · San Francisco, California · NCT04621435

• Testing different radiation schedules for metastatic prostate cancer

  This study is testing whether a more intense radiation schedule works better and causes fewer side effects for people with newly diagnosed metastatic prostate cancer.

  Recruiting Umeå University · Umeå · NCT04612907

• Evaluating PC14586 for advanced solid tumors with a specific mutation

  This study is testing a new oral medication called PC14586 to see if it can help people with advanced solid tumors that have a specific mutation in the TP53 gene.

  Recruiting at 71 sites Phase 1/2 PMV Pharmaceuticals, Inc · Irvine, California and 75 other locations · NCT04585750

• Comparing how often to give nivolumab or pembrolizumab for advanced cancers

  This study is testing if giving nivolumab or pembrolizumab less often can still help people with advanced cancers just as well as the usual schedule.

  Recruiting at 2 sites Phase 1 University of Chicago · Chicago, Illinois and 1 other locations · NCT04295863

• Study of immune resistance in cancer patients after immunotherapy

  This study is trying to understand why some cancer patients don’t respond to immunotherapy while others do, by looking at their tumor and blood samples.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT04243720

• Registry to assess adverse events from ablative radiotherapy in metastatic cancer

  This study is trying to collect information about side effects from a specific type of radiation treatment for adults with metastatic cancer to better understand how safe it is.

  Recruiting at 5 sites Duke University · Cary, North Carolina and 4 other locations · NCT04085029

NIH-funded research (19)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Whole-Body Redox Maps to Guide Prostate Cancer Therapy

  A new research project will map redox states across the body to understand how prostate cancer and its spread respond to therapy.

  NIH research Cold Spring Harbor Laboratory · Cold Spring Harbor, United States · NIH-11434570

• Digital activity tracking to understand metastatic breast cancer care

  A smartphone-based activity tracking study will help people with metastatic cancer better understand how daily movement relates to health and treatment outcomes.

  NIH research Sloan-Kettering Inst Can Research · New York, United States · NIH-11430629

• Measuring how cancer patients and doctors talk to each other to improve treatment outcomes

  This project uses machine learning to study how patient-provider conversations affect cancer patients’ use of oral therapies and their health results.

  NIH research Yale University · New Haven, United States · NIH-11357591

• Symptoms and quality of life during immunotherapy for metastatic cancer

  The team will track symptoms and day-to-day quality of life in people with metastatic cancer who are receiving immune checkpoint inhibitor treatments.

  NIH research University of Miami School of Medicine · Coral Gables, United States · NIH-11267220

• A New Treatment for Metastatic Cancer

  This project is exploring a brand-new treatment designed to specifically target and remove metastatic cancer cells in people with advanced cancer.

  NIH research Transcode Therapeutics, INC. · Boston, United States · NIH-11182730

• How cancer cells release proteins that help tumors spread

  This project is learning how tumor cells send out certain proteins that help cancer move to other parts of the body, with the goal of helping people with metastatic cancer.

  NIH research Saint Louis University · Saint Louis, United States · NIH-11133044

• Making palliative care work better for people with metastatic cancer

  This project aims to find what helps specialist palliative care give better support and quality of life for people with metastatic cancer.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11129108

• Understanding Opioid Pain Treatment for Metastatic Cancer

  This project looks at how opioid medications help or harm people with metastatic cancer who are managing pain.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11118820

• Understanding how communication between patients and providers affects cancer treatment outcomes

  This study is looking at how good communication between cancer patients and their doctors can help patients stick to their oral treatments better, using technology to understand how they talk to each other and improve their interactions.

  NIH research Yale University · New Haven, United States · NIH-11109737

• Understanding the supportive care needs of Asian Americans with metastatic cancer

  This study is looking at the unique support needs of Asian American patients with advanced cancer, especially those from Chinese, Vietnamese, and Korean backgrounds, to create helpful resources that respect their cultural values and improve their care.

  NIH research University of California-Irvine · Irvine, United States · NIH-11072131

• Understanding what makes palliative care effective for patients with metastatic cancer

  This study looks at how different parts of palliative care teams can improve the quality of life for people with advanced cancer, aiming to find the best ways to support patients and help hospitals provide better care.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11044074

• Understanding side effects and quality of life for diverse patients using immune therapies for cancer.

  This study is looking at how different people with advanced cancer feel while getting immune checkpoint inhibitors, focusing on their side effects and quality of life, to help improve support and care for patients like you.

  NIH research University of Miami School of Medicine · Coral Gables, United States · NIH-11040016

• Testing a new therapy for metastatic cancer

  This study is testing a new treatment called MN-anti-miR10b that aims to help people with metastatic cancer by targeting and eliminating cancer cells, and it may be used alongside low-dose chemotherapy to help shrink tumors.

  NIH research Transcode Therapeutics, INC. · Boston, United States · NIH-11005913

• Improving palliative care access for Hispanic/Latino patients with metastatic cancer

  This study is all about helping Hispanic and Latino patients with advanced cancer get better support and care by making it easier for them and their families to talk about their treatment options, so they can enjoy a better quality of life.

  NIH research University of Miami School of Medicine · Coral Gables, United States · NIH-10912698

• Understanding the supportive care needs of Asian Americans with metastatic cancer

  This study is looking to understand the special support needs of Asian American patients with advanced cancer, especially those from Chinese, Vietnamese, and Korean backgrounds, so that we can create helpful resources that respect their cultural values and preferences in cancer care.

  NIH research University of California-Irvine · Irvine, United States · NIH-10892672

• Understanding how certain proteins are released in metastatic cancer

  This study is looking at how certain proteins are released from cells in unusual ways when they are under stress, like in cancerous tumors, to find new treatment options that could help improve care for cancer patients.

  NIH research Saint Louis University · Saint Louis, United States · NIH-10880671

• How bone changes in response to primary and metastatic cancer

  This study looks at how a primary breast tumor changes the bone environment and affects immune and bone cells before cancer spreads, with the goal of finding new ways to improve treatment for patients like you.

  NIH research Washington University · Saint Louis, United States · NIH-10880414

• Investigating opioid therapy for pain management in metastatic cancer patients

  This study is looking to learn more about how opioids can help manage pain for people with metastatic cancer, and it invites patients and healthcare providers to share their experiences to improve pain relief options safely.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-10864049

• Reversing cancer cell changes that help tumors spread using special materials and heat.

  This study is exploring a new way to help people with metastatic cancer by using special materials and gentle heat to make cancer cells easier to treat with regular chemotherapy.

  NIH research South Dakota School of Mines and Techn'y · Rapid City, United States · NIH-10514841

Related topics

Quick answers

How many Metastatic Cancer clinical trials are recruiting right now?

74, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 33 countries. The most sites are in United States (44 trials), Australia (9 trials), China (9 trials), France (8 trials), Canada (5 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1: 18, Phase 2: 16, Phase 1/2: 12, Phase 3: 5. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

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