Condition

Metastatic Solid Tumor clinical trials and research

• 50Clinical trials
• 19Countries

Newest Metastatic Solid Tumor clinical trials

All recruiting trials (50)

• Adding targeted GRID-style radiation to standard palliative therapy for unresectable solid tumors

  This study tests whether adding spatially fractionated radiation therapy to standard palliative radiation helps relieve symptoms in patients with unresectable solid tumors.

  Recruiting at 2 sites Mayo Clinic · Scottsdale, Arizona and 1 other locations · NCT07856394

• BG-85738 alone or with other anticancer drugs in RAS-mutant advanced or metastatic solid tumors

  This study tests BG-85738, alone or with other cancer drugs, in adults whose solid tumors have RAS mutations and have progressed.

  Recruiting at 3 sites Phase 1 BeOne Medicines · South Brisbane, Queensland and 2 other locations · NCT07746141

• DS1025a: first-in-human test in advanced solid tumors

  This first-in-human trial tests DS1025a in adults with advanced, metastatic, or unresectable solid tumors to see if it is safe and tolerable and to look for early signs of activity.

  Recruiting at 3 sites Phase 1 Daiichi Sankyo · Kashiwa and 2 other locations · NCT07681882

• MSK-TCR5 in adults with advanced solid tumors that have KRAS/HRAS/NRAS G12D

  This study tests MSK-TCR5 to see if it is safe for adults with advanced solid tumors carrying a KRAS, HRAS, or NRAS G12D mutation.

  Recruiting at 7 sites Phase 1 Memorial Sloan Kettering Cancer Center · Basking Ridge, New Jersey and 6 other locations · NCT07638371

• IDP-001 in advanced or metastatic solid tumors (including head and neck and skin cancers)

  A first- and second-phase study will test IDP-001 in people with advanced or metastatic solid tumors to see if it is safe and tolerable and to look for signs of activity.

  Recruiting at 6 sites Phase 1/2 InduPro, Inc. · Los Angeles, California and 5 other locations · NCT07602842

• Prophylactic Radiotherapy to Prevent Bone Complications in Metastatic Cancers

  This study tests whether giving early radiotherapy to high-risk bone metastases, in addition to standard care, can reduce bone-related problems in adults with metastatic solid cancers.

  Recruiting Phase 2 Institute of Oncology Ljubljana · Ljubljana · NCT07540650

• First-in-human test of ZE94-0605 for advanced solid tumors

  This first-in-human trial tests ZE94-0605, an oral CDK2 inhibitor, in adults with advanced or metastatic solid tumors to find a safe dose and explore early signs of activity.

  Recruiting at 3 sites Phase 1 Eilean Therapeutics · Kogarah, New South Wales and 2 other locations · NCT07524140

• ITC-6146RO in advanced cancers beyond standard therapy

  A new drug called ITC-6146RO is being tested to see if it is safe and can help people with advanced cancers who have no other approved options.

  Recruiting at 3 sites Phase 1 IntoCell, Inc · Seoul, Seoul and 2 other locations · NCT07423117

• PLX-61639 for advanced SMARCA4-deficient solid tumors

  This trial will test a daily oral drug called PLX-61639 in people with advanced or metastatic solid tumors that have a SMARCA4 loss and who have no other approved treatment options.

  Recruiting at 10 sites Phase 1 Plexium, Inc. · Scottsdale, Arizona and 9 other locations · NCT07284186

• IPN01203 for adults with advanced or metastatic solid tumors after immune checkpoint therapy

  We will test whether the experimental drug IPN01203 is safe and can slow or stop tumor growth in adults with advanced or metastatic solid tumors who previously received immune checkpoint inhibitors.

  Recruiting at 10 sites Phase 1/2 Ipsen · Grand Rapids, Michigan and 9 other locations · NCT07213830

• Safety and anti-tumor activity of IPN60300 in adults with advanced or metastatic solid tumors

  This trial will test whether injections of IPN60300 are safe and can help control advanced or metastatic solid tumors in adults.

  Recruiting at 10 sites Phase 1/2 Ipsen · New Haven, Connecticut and 11 other locations · NCT07213817

• GI-108 monotherapy for people with advanced or metastatic solid tumors

  We are testing GI-108 by itself to see if it is safe and can shrink tumors in people with advanced or metastatic solid tumors, including lung, head and neck, and pancreatic cancers.

  Recruiting at 3 sites Phase 1/2 GI Innovation, Inc. · Seoul and 2 other locations · NCT07172802

• SYN818 plus olaparib for advanced or metastatic BRCA‑mutant or HRD solid tumors

  This study tests whether combining SYN818 with olaparib is safe and helps control advanced or metastatic solid tumors in adults whose cancers have BRCA mutations or homologous recombination repair defects.

  Recruiting at 2 sites Phase 1 Hangzhou SynRx Therapeutics Biomedical Technology Co., Ltd · Shanghai, Shanghai Municipality and 1 other locations · NCT07156253

• BSI-082 Alone or with Trastuzumab Deruxtecan in Advanced Solid Tumors

  This early-stage study tests BSI-082 by itself and then with Trastuzumab deruxtecan to see if higher doses are safe and tolerable in adults with advanced or metastatic solid tumors.

  Recruiting Phase 1 The University of Texas Health Science Center at San Antonio · San Antonio, Texas · NCT07086768

• YH32364 for locally advanced or metastatic EGFR‑overexpressing solid tumors

  This trial will test whether YH32364 can help adults with advanced or metastatic cancers that overexpress EGFR when other treatments haven't worked.

  Recruiting at 4 sites Phase 1/2 Yuhan Corporation · Seoul and 3 other locations · NCT06975410

• Oral MOMA-341 for advanced or metastatic MSI-H or dMMR solid tumors

  This trial will test whether the oral drug MOMA-341, alone or with irinotecan or immunotherapy, can be safe and show anti-tumor activity in adults with advanced or metastatic MSI-H/dMMR solid tumors who have progressed after prior PD-(L)1 therapy.

  Recruiting at 13 sites Phase 1 MOMA Therapeutics · Phoenix, Arizona and 14 other locations · NCT06974110

• Testing XB628 for advanced or metastatic solid tumors

  This study is testing a new treatment called XB628 to see if it can help people with advanced or metastatic solid tumors by finding the right dose that is safe and effective.

  Recruiting at 11 sites Phase 1 Exelixis · San Francisco, California and 10 other locations · NCT06952010

• Treatment of advanced or metastatic solid tumors with BGB-B455

  This study is testing a new treatment called BGB-B455 to see if it can help adults with advanced or metastatic solid tumors feel better and improve their condition.

  Recruiting at 10 sites Phase 1 BeOne Medicines · Celebration, Florida and 10 other locations · NCT06803680

• Treatment for adult patients with solid tumors that have a specific p53 mutation

  This study is testing a new treatment for adults with advanced solid tumors that have a specific p53 mutation to see if it is safe and effective.

  Recruiting at 21 sites Phase 1 Clasp Therapeutics, Inc. · Scottsdale, Arizona and 20 other locations · NCT06778863

• SYN818 for advanced or metastatic solid tumors

  This Phase 1 study will test oral SYN818 in adults with advanced or metastatic solid tumors, including breast, ovarian, and prostate cancers, whose standard treatments have been exhausted.

  Recruiting at 2 sites Phase 1 Hangzhou SynRx Therapeutics Biomedical Technology Co., Ltd · Zhengzhou, Henan and 1 other locations · NCT06666270

• Evaluating CHS-114 with Toripalimab for Advanced Solid Tumors

  This study is testing a new treatment combining CHS-114 and toripalimab to see if it helps people with advanced stomach or esophageal cancer feel better.

  Recruiting at 28 sites Phase 1 Coherus Oncology, Inc. · Tucson, Arizona and 29 other locations · NCT06657144

• Analyzing patient characteristics for advanced cancer treatment

  This study looks at the personal and lifestyle factors of cancer patients starting their first treatment to see how these affect their response to the treatment.

  Recruiting at 9 sites Centro Nacional de Investigaciones Oncologicas CARLOS III · A Coruña, A Coruña/ Galicia and 8 other locations · NCT06590506

• Intramuscular ACM-CpG treatment for advanced solid tumors

  This study is testing a new injection treatment for people with advanced solid tumors who have already tried immunotherapy to see if it is safe and effective.

  Recruiting Phase 1 National Cancer Centre, Singapore · Singapore · NCT06587295

• Assessing the safety and effectiveness of BC3195 in advanced cancer patients

  This study is testing a new drug called BC3195 to see if it is safe and effective for people with advanced cancer who haven't had success with other treatments.

  Recruiting Phase 1 Biocity Biopharmaceutics Co., Ltd. · Cleveland, Ohio · NCT06548672

• Oral treatment with MOMA-313 for advanced solid tumors

  This study is testing a new oral treatment called MOMA-313 for people with advanced solid tumors that can't be cured, to see how safe it is and how well it works, especially for those with certain genetic changes.

  Recruiting at 14 sites Phase 1 MOMA Therapeutics · Goodyear, Arizona and 17 other locations · NCT06545942

• Evaluating NVL-330 for advanced HER2-altered lung cancer

  This study is testing a new treatment called NVL-330 to see if it can safely help people with advanced lung cancer that has changes in the HER2 gene.

  Recruiting at 20 sites Phase 1 Nuvalent Inc. · Irvine, California and 20 other locations · NCT06521554

• LY4052031 for advanced or metastatic urothelial and other nectin‑4–expressing solid tumors

  This trial will test whether LY4052031 is safe and can help people with advanced or metastatic urothelial cancer or other solid tumors that express nectin‑4.

  Recruiting at 36 sites Phase 1 Eli Lilly and Company · Duarte, California and 39 other locations · NCT06465069

• Evaluating AGX101 for advanced solid tumors

  This study is testing a new drug called AGX101 to see if it can help people with advanced solid tumors who haven't had success with other treatments.

  Recruiting at 7 sites Phase 1 Angiex, Inc. · Los Angeles, California and 6 other locations · NCT06440005

• Treatment of advanced solid tumors using ACE2016 cell therapy

  This study is testing a new cell therapy called ACE2016 to see if it can help people with advanced solid tumors that have not improved with other treatments.

  Recruiting at 4 sites Phase 1 Acepodia Biotech, Inc. · San Diego, California and 8 other locations · NCT06415487

• Using topical tretinoin to prevent skin issues from cancer treatment

  This study is testing if a cream called tretinoin can help reduce skin rashes for patients with metastatic colorectal cancer who are receiving certain cancer treatments.

  Recruiting Phase 2 University of Utah · Salt Lake City, Utah · NCT06358677

• Combining Afatinib and Pemigatinib for Advanced Solid Tumors

  This study is testing a combination of two drugs, Afatinib and Pemigatinib, to see if they can safely help people with advanced solid tumors that have specific genetic changes.

  Recruiting Phase 1 Massachusetts General Hospital · Boston, Massachusetts · NCT06302621

• Evaluating FMC-376 for advanced solid tumors with KRAS G12C mutations

  This study is testing a new drug called FMC-376 to see if it can help people with advanced solid tumors that have a specific KRAS G12C mutation.

  Recruiting at 20 sites Phase 1/2 Frontier Medicines Corporation · La Jolla, California and 25 other locations · NCT06244771

• Evaluating the safety and effectiveness of ASD141 for advanced solid tumors

  This study is testing a new drug called ASD141 to see if it is safe and effective for people with advanced solid tumors.

  Recruiting at 2 sites Phase 1 Ascendo Biotechnology Co., Ltd. · Tainan and 1 other locations · NCT06235437

• Testing a new treatment for advanced solid tumors

  This study is testing a new treatment called tolododekin alfa for people with advanced solid tumors that haven't improved with standard therapies to see how safe it is and how well it works.

  Recruiting at 5 sites Phase 1 Ankyra Therapeutics, Inc · Bethesda, Maryland and 4 other locations · NCT06171750

• JZP898 infusion for advanced metastatic solid tumors

  This study is testing a new treatment called JZP898, alone and with another drug, to see if it can help adults with advanced solid tumors feel better and improve their health.

  Recruiting at 10 sites Phase 1 Jazz Pharmaceuticals · Encinitas, California and 9 other locations · NCT06108050

• PEP07 for patients with advanced or metastatic solid tumors

  This study is testing a new drug called PEP07 to see if it is safe and what the best dose is for people with advanced or metastatic solid tumors who haven't had success with other treatments.

  Recruiting at 3 sites Phase 1 PharmaEngine · Taichung and 2 other locations · NCT05983523

• Evaluating ART6043 for patients with advanced metastatic solid tumors

  This study is testing a new oral cancer drug called ART6043, alone or with other medications, to see how safe it is and if it can help people with advanced metastatic solid tumors, especially certain types of breast cancer.

  Recruiting at 20 sites Phase 1/2 Artios Pharma Ltd · Grand Rapids, Michigan and 26 other locations · NCT05898399

• Testing DS-3939a for advanced solid tumors

  This study is testing a new drug called DS-3939a to see if it can safely help people with advanced solid tumors feel better.

  Recruiting at 43 sites Phase 1/2 Daiichi Sankyo · Sarasota, Florida and 60 other locations · NCT05875168

• Evaluating a new treatment for advanced solid tumors

  This study is testing a new treatment called ADU-1805 for people with advanced solid tumors to see how safe it is and how well it works on its own and with another drug.

  Recruiting at 11 sites Phase 1 Sairopa B.V. · Detroit, Michigan and 10 other locations · NCT05856981

• Comparing two radiation therapy techniques for advanced solid tumors

  This study is testing whether a new type of radiation therapy works better than the standard method for treating advanced solid tumors that have spread, to see if it can improve outcomes for patients needing palliative care.

  Recruiting at 7 sites Memorial Sloan Kettering Cancer Center · Basking Ridge, New Jersey and 6 other locations · NCT05837767

• Evaluating GI-102 for advanced solid tumors with or without other cancer drugs

  This study is testing a new cancer treatment called GI-102, both on its own and with other cancer drugs, to see how safe it is and how well it works for people with advanced solid tumors.

  Recruiting at 11 sites Phase 1/2 GI Innovation, Inc. · Scottsdale, Arizona and 10 other locations · NCT05824975

• Combining niraparib and irinotecan for cancers with DNA repair gene mutations

  This study is testing a new combination of two cancer drugs, niraparib and irinotecan, to see if it's safe and effective for people with certain types of cancer that have DNA repair gene mutations.

  Recruiting Phase 1 University of California, San Francisco · San Francisco, California · NCT05694715

• Combination treatment for HER2-positive metastatic solid tumors with brain metastases

  This study is testing if a combination of two drugs can help people with HER2-positive metastatic solid tumors that have spread to the brain feel better and live longer.

  Recruiting Phase 2 M.D. Anderson Cancer Center · Houston, Texas · NCT05673928

• Evaluating NVL-655 for Advanced ALK-Positive Solid Tumors

  This study is testing a new drug called NVL-655 to see if it can safely help people with advanced ALK-positive solid tumors, including non-small cell lung cancer.

  Recruiting at 73 sites Phase 1/2 Nuvalent Inc. · Orange, California and 73 other locations · NCT05384626

• Testing the safety and dosing of zeaxanthin for advanced cancer treatment

  This study is testing how much zeaxanthin, a natural compound, can be safely given to people with advanced cancer to see if it helps them without causing bad side effects.

  Recruiting Phase 1 Valley Health System · Paramus, New Jersey · NCT05232409

• Evaluating NVL-520 for Advanced ROS1-positive Solid Tumors

  This study is testing a new drug called NVL-520 to see if it can safely help people with advanced solid tumors that have a specific genetic change called ROS1.

  Recruiting at 58 sites Phase 1/2 Nuvalent Inc. · Orange, California and 62 other locations · NCT05118789

• Testing repotrectinib with chemotherapy for children and young adults with advanced solid tumors

  This study is testing if the drug repotrectinib, when combined with chemotherapy, can help children and young adults with advanced solid tumors feel better and improve their treatment outcomes.

  Recruiting Phase 1/2 Memorial Sloan Kettering Cancer Center · New York, New York · NCT05004116

• Evaluating GI-101 with Pembrolizumab, Lenvatinib, or Radiotherapy in Advanced Solid Tumors

  This study is testing a new treatment called GI-101, alone and with other therapies, to see if it can help people with advanced solid tumors.

  Recruiting at 13 sites Phase 1/2 GI Innovation, Inc. · New York, New York and 12 other locations · NCT04977453

• Evaluating PC14586 for advanced solid tumors with a specific mutation

  This study is testing a new oral medication called PC14586 to see if it can help people with advanced solid tumors that have a specific mutation in the TP53 gene.

  Recruiting at 71 sites Phase 1/2 PMV Pharmaceuticals, Inc · Irvine, California and 75 other locations · NCT04585750

• Evaluating the safety and early effectiveness of IL12-L19L19 in advanced solid tumors

  This study is testing a new treatment called IL12-L19L19 to see if it's safe and effective for people with advanced solid tumors who have already tried other immune therapies.

  Recruiting at 9 sites Phase 1 Philogen S.p.A. · Hamburg, Free and Hanseatic City of Hamburg and 10 other locations · NCT04471987

Related topics

Quick answers

How many Metastatic Solid Tumor clinical trials are recruiting right now?

50, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 19 countries. The most sites are in United States (36 trials), South Korea (11 trials), Spain (11 trials), Australia (10 trials), France (7 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1: 30, Phase 1/2: 14, Phase 2: 3. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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