Helping Families Support Loved Ones with Advanced Cancer in Making Health Decisions

Decision Support Training for Advanced Cancer Family Caregivers: The CASCADE Factorial Trial

NIH-funded research University of Alabama at Birmingham · NIH-11112423

This project offers a program to teach family caregivers of people with advanced cancer how to best support their loved ones when making important health choices.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionUniversity of Alabama at Birmingham NIH-funded
Lab location1 site (Birmingham, United States)
Project IDNIH-11112423 on NIH RePORTER

What this research studies

When someone has advanced cancer, their family often helps them make big health decisions about treatments, care locations, and palliative care. This project aims to prepare these family caregivers to be effective partners in these discussions. We are testing a program called CASCADE, which uses a lay navigator through telehealth to teach caregivers communication skills and how to use decision guides. The goal is to help patients make choices that truly match their values and preferences, reducing distress for both patients and their families.

Who could benefit from this research

Good fit: This program is designed for family caregivers of adults (21+ years old) living with advanced cancer, especially those in underserved communities.

Not a fit: Patients without a primary family caregiver involved in their health decisions, or those not dealing with advanced cancer, may not directly benefit from this specific program.

Why it matters

Potential benefit: If successful, this program could help patients with advanced cancer make more informed decisions aligned with their wishes, while also reducing stress for their family caregivers.

How similar studies have performed: While few palliative care interventions have specifically focused on enhancing caregiver decision support skills, this program builds upon prior successful early palliative care caregiving interventions.

Where this research is happening

Birmingham, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions Advanced CancerCancer FamilyCancer PatientCancer TreatmentCancers
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.