Engage: A Telehealth Program to Help Patients with Advanced Cancer Manage Symptoms

Engage: A Randomized Controlled Trial Testing the Efficacy of a Telehealth-Delivered Psychosocial Intervention to Decrease Symptom Interference in Patients with Advanced Cancer

NIH-funded research Duke University · NIH-11158704

This program offers a telehealth-delivered approach to help patients with advanced cancer better manage symptoms like pain, fatigue, and distress that interfere with their daily lives.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionDuke University NIH-funded
Lab location1 site (Durham, United States)
Project IDNIH-11158704 on NIH RePORTER

What this research studies

Patients living with advanced cancer often experience challenging symptoms such as pain, tiredness, and emotional distress, which can make it hard to live life fully. Current medical treatments for these symptoms sometimes have side effects or don't fully address all concerns. This program, called ENGAGE, combines traditional coping skills with acceptance and mindfulness techniques to help you reduce symptom severity and accept experiences that cannot be changed. The goal is to lessen how much these symptoms disrupt your life and improve your overall well-being. This approach is delivered remotely, making it accessible from your home.

Who could benefit from this research

Good fit: Ideal candidates are patients with advanced cancer who are experiencing significant pain, fatigue, or distress that interferes with their daily activities.

Not a fit: Patients who do not have advanced cancer or are not experiencing significant symptom interference may not find this program beneficial.

Why it matters

Potential benefit: If successful, this program could offer patients with advanced cancer a new way to reduce the impact of difficult symptoms on their daily lives and significantly improve their quality of life.

How similar studies have performed: Pilot programs using this approach have shown promising results, but this larger effort aims to confirm its effectiveness in a more comprehensive way.

Where this research is happening

Durham, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions Advanced CancerCancers
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.