Optimizing mercaptopurine treatment for children with leukemia

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study focuses on children diagnosed with acute lymphoblastic leukemia (ALL) and aims to optimize the maintenance phase of treatment using mercaptopurine (MP). The study will monitor the therapeutic drug levels of MP to ensure effective dosing and minimize potential toxicities associated with the medication. By analyzing individual responses to MP, the research seeks to improve event-free survival rates in pediatric patients undergoing treatment for ALL. The study involves collaboration with several pediatric hospitals in Italy to gather comprehensive data on treatment outcomes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Newly diagnosed ALL
* Age \<18 years at diagnosis
* Written informed consent given

Exclusion Criteria:

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Where it's running

• Fondazione MBBM / A.O. San Gerardo
  Monza, Monza Brianza, Italy Recruiting
• IRCCS Ospedale Pediatrico "Bambino Gesù"
  Roma, Italy Recruiting
• Presidio Infantile Regina Margherita
  Torino, Italy Recruiting
• IRCCS materno infantile Burlo Garofolo
  Trieste, Italy Recruiting

Study contacts

• Study coordinator: Marco Rabusin, MD
• Email: marco.rabusin@burlo.trieste.it
• Phone: +390403785111

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.