Understanding how genetic changes in the ETV6 gene lead to childhood leukemia
Pathogenesis of ETV6-Related Acute Lymphoblastic Leukemia
This study is looking at how certain genes, especially the ETV6 gene, might play a role in causing acute lymphoblastic leukemia (ALL) in kids, especially those with a family history of low platelet counts, to help find better ways to treat the disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | St. Jude Children's Research Hospital NIH-funded |
| Lab location | 1 site (Memphis, United States) |
| Project ID | NIH-11163330 on NIH RePORTER |
What this research studies
This research investigates the genetic factors that contribute to acute lymphoblastic leukemia (ALL) in children, specifically focusing on the ETV6 gene. By studying families with a history of thrombocytopenia and B-ALL, researchers aim to identify how specific genetic variants affect the development of leukemia. The approach includes sequencing samples from children diagnosed with B-ALL to find common genetic mutations and using laboratory models to understand how these mutations disrupt normal cell function. This research could provide insights into the mechanisms of leukemia and potentially lead to new treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are children under 11 years old who have been diagnosed with acute lymphoblastic leukemia.
Not a fit: Patients with other types of leukemia or those over the age of 11 may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for children with acute lymphoblastic leukemia.
How similar studies have performed: Previous research has shown success in identifying genetic factors associated with leukemia, making this approach promising.
Where this research is happening
Memphis, United States
- St. Jude Children's Research Hospital — Memphis, United States (Active)
Researchers
- Principal investigator: Nichols, Kim Erika — St. Jude Children's Research Hospital
- Study coordinator: Nichols, Kim Erika
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.