Exercise, lung, and heart fitness in young survivors of heart transplant, childhood leukemia, and premature lung disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational project uses standardized, non-invasive exercise testing and respiratory measurements to document cardiac function, ventilation, and exercise capacity in three groups aged 8–25: acute lymphoblastic leukemia survivors, individuals with chronic lung disease of prematurity, and heart transplant recipients. Participants complete supervised exercise protocols with concurrent heart and breathing measurements, and results are compared with healthy age-matched controls. The goal is to characterize exercise intolerance, identify physiologic limitations, and expand testing capabilities for clinical care and research. Findings are intended to inform evidence-based exercise guidance and improve understanding of long-term implications as these individuals age.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Cases:

  * Acute lymphoblastic leukemia survivor, OR living with chronic lung disease of prematurity, OR living with heart transplant
  * 8-25 years old
  * Height: ≥ 48 inches
  * Ambulatory without assistance
  * English speaking
  * Normotensive (\<95th percentile for age; okay if managed with antihypertensive medication)
  * SpO2 \>92%
  * Not pregnant
  * ALL survivor specific: must have completed therapy ≥ 3 months prior to study entry
* Controls

  * 8-25 years old
  * Height: ≥ 48 inches
  * Ambulatory without assistance
  * English speaking
  * No history of arrhythmia or known cardiac dysfunction at baseline
  * Normotensive (\<95th percentile for age; okay if managed with antihypertensive medication)
  * SpO2 \>95%
  * Not pregnant

Exclusion Criteria:

* Cases:

  * ALL specific: received cranial radiation, bone marrow transplant recipients
  * Investigator or patient's primary physician deems the patient unsuitable for the study
* Controls:

  * History of malignancy, CLD or HT or any other diagnosis which may reduce cardiorespiratory function
  * Investigator deems the patient unsuitable for the study

Where it's running

• Masonic Cancer Center
  Minneapolis, Minnesota, United States Recruiting

Study contacts

• Principal investigator: Pianosi Paolo, MD — Masonic Children's Hospital, University of Minnesota
• Study coordinator: Char Napurski, MPH, CCRP
• Email: bake0257@umn.edu
• Phone: 612-626-2140

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.