Child and Young Adult (CAYA) Cancer Outcomes Review

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This retrospective cohort review collects medical record data from participating centers in low- and middle-income countries to describe treatment patterns and outcomes for children and young adults (0–21) diagnosed with cancer in the past 15 years, with a focus on acute lymphoblastic leukemia and lymphoblastic lymphoma. Data will include diagnosis details, treatments (chemotherapy, surgery, radiation, immunotherapy), timing of care, comorbidities, and outcomes such as treatment failure and survival. The project aims to identify system- and patient-level factors linked to poor outcomes and to inform targeted, evidence-based interventions to reduce disparities. The registry is led by Resonance, Inc. with collaborators including Servier and site partners in Armenia, El Salvador, and Guatemala.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Subjects must meet all the following criteria to be included in this registry:

1. Participants must be willing and able to provide informed consent prior to enrollment in the registry.

   1. For minors or individuals unable to provide informed consent, assent must be obtained along with consent from a legal guardian.
   2. Note: Exemption applies to this criterion when waiver of informed consent/assent is granted by Institutional Review Board(IRB)/Independent Ethics Committee(IEC)/Competent Authorities(CAs).
2. A confirmed diagnosis of any type of cancer within the 15 years prior to the site's activation date.
3. Age 0 to 21 years at the time of diagnosis.
4. Received substantial anti-cancer treatment at the participating center, including but not limited to:

   1. Chemotherapy
   2. Surgery
   3. Radiation therapy
   4. Immunotherapy
5. Medical records are available and accessible for review

Exclusion Criteria:

* Subjects meeting any of the following criteria will be excluded from this registry:

  1. Patients who only visited the participating center for:

     1. Consultation without subsequent primary anti-cancer treatment at the participating center
     2. Pathology, radiology, or other diagnostic evaluations without treatment

Where it's running

• Yeolyan Center for Cancer and Blood Disorders
  Yerevan, Armenia Recruiting
• Fundación Ayúdame a Vivir
  El Salvador, El Salvador, El Salvador Recruiting
• Unidad Nacional de Oncología Pediátrica (UNOP)
  Guatemala City, Guatemala Recruiting
• Hospital Mario Catarino Rivas
  San Pedro Sula, Cortés Department, Honduras Recruiting
• Hospital Escuela
  Tegucigalpa, Distrito Central, Honduras Recruiting
• The Children's Cancer Hospital Egypt 57357
  Cairo, Egypt Not yet recruiting

Study contacts

• Study coordinator: Gabriela Villanueva, MD.
• Email: gabriela.villanueva@resonancehealth.org
• Phone: +1-901-205-9518

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.