Genetics of childhood acute lymphoblastic leukemia
Genomics of childhood acute lymphoblastic leukemia in the Childhood Cancer and Leukemia International Consortium
['FUNDING_R01'] · UNIVERSITY OF MINNESOTA · NIH-11407899
This project looks at how inherited genes affect the risk of acute lymphoblastic leukemia in children from many countries and ancestry groups.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MINNESOTA (nih funded) |
| Locations | 1 site (MINNEAPOLIS, UNITED STATES) |
| Trial ID | NIH-11407899 on ClinicalTrials.gov |
What this research studies
If your child has or had acute lymphoblastic leukemia (ALL), this project gathers DNA and health information from children around the world to search for genetic differences tied to risk. Researchers compare genomes from children with ALL to those without the disease, use genome-wide scans to find common genetic variants, and build polygenic risk scores to measure inherited risk. The work is done through an international consortium that combines samples and data from many regions, especially places with high ALL burden. By including diverse ancestry groups, the team aims to explain why ALL rates differ across populations.
Who could benefit from this research
Good fit: Ideal participants are children and young adults diagnosed with ALL and unaffected children from diverse ancestral backgrounds who can provide DNA samples and basic health information.
Not a fit: People without available DNA samples or those seeking immediate changes to their current treatment plan are unlikely to receive direct clinical benefit from joining this research.
Why it matters
Potential benefit: If successful, this work could help identify children at higher inherited risk for ALL and inform earlier detection or targeted prevention efforts in the future.
How similar studies have performed: Previous genome-wide studies have already found multiple inherited variants linked to childhood ALL and produced polygenic risk scores, but large, diverse international analyses remain limited.
Where this research is happening
MINNEAPOLIS, UNITED STATES
- UNIVERSITY OF MINNESOTA — MINNEAPOLIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SPECTOR, LOGAN G. — UNIVERSITY OF MINNESOTA
- Study coordinator: SPECTOR, LOGAN G.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.