Genetics of childhood acute lymphoblastic leukemia
Official title: Genomics of childhood acute lymphoblastic leukemia in the Childhood Cancer and Leukemia International Consortium
Funded at University of Minnesota · NIH-11407899 · Data updated 2026-11-12
This project looks at how inherited genes affect the risk of acute lymphoblastic leukemia in children from many countries and ancestry groups.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project start | August 22, 2022 |
| Project end | July 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $101,629 |
| NIH project number | 3R01CA266253-04S1 |
| Project ID | NIH-11407899 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal participants are children and young adults diagnosed with ALL and unaffected children from diverse ancestral backgrounds who can provide DNA samples and basic health information.
✕Less likely to help
People without available DNA samples or those seeking immediate changes to their current treatment plan are unlikely to receive direct clinical benefit from joining this research.
What this research studies
If your child has or had acute lymphoblastic leukemia (ALL), this project gathers DNA and health information from children around the world to search for genetic differences tied to risk. Researchers compare genomes from children with ALL to those without the disease, use genome-wide scans to find common genetic variants, and build polygenic risk scores to measure inherited risk. The work is done through an international consortium that combines samples and data from many regions, especially places with high ALL burden. By including diverse ancestry groups, the team aims to explain why ALL rates differ across populations.
Why it matters
Potential benefit: If successful, this work could help identify children at higher inherited risk for ALL and inform earlier detection or targeted prevention efforts in the future.
How similar studies have gone: Previous genome-wide studies have already found multiple inherited variants linked to childhood ALL and produced polygenic risk scores, but large, diverse international analyses remain limited.
Where this research is happening
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University of Minnesota
Minneapolis, United States Active
Researchers
- Principal investigator: Spector, Logan G. — University of Minnesota
- Study coordinator: Spector, Logan G.
Related research
Other NIH-funded projects on the same topics.
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Genomics of childhood ALL across global populations
A wide-ranging study looks at how inherited genetics influence the risk of childhood acute lymphoblastic leukemia around the world.
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Genomics of childhood ALL across diverse populations
A large international study will look at why children everywhere get acute lymphoblastic leukemia and how genetics may influence risk.
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Genomics of childhood acute lymphoblastic leukemia across global populations
This grant studies how inherited genes influence the risk of childhood ALL around the world to understand why some groups are more affected.
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Childhood acute lymphoblastic leukemia genetics around the world
This project compares inherited genetic differences in children with and without acute lymphoblastic leukemia across many countries to learn who is at higher risk.
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How inherited genes affect childhood acute lymphoblastic leukemia worldwide
This project looks at inherited gene differences that relate to the risk of children developing acute lymphoblastic leukemia across many countries.
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Understanding the genetics of childhood acute lymphoblastic leukemia
This study is looking at how certain genes might make kids aged 0-14 more likely to get acute lymphoblastic leukemia (ALL), and it hopes to find ways to better prevent and treat the disease by understanding how different backgrounds can affect this risk.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.