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Clinical trials and research at Thomas Jefferson University
As of November 12, 2026, Find a Trial lists 54 clinical trials run by Thomas Jefferson University that are recruiting, at sites in 2 countries (most in United States (54), Switzerland (1)). 2 were first registered in the last 30 days. By phase: Phase 2 (9), Phase 1 (4), Phase 1/2 (2), Early Phase 1 (1). There are also 336 NIH-funded research projects at this institution, with $152.8 million in listed awards. Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 54Clinical trials
- 336NIH research projects
- 2New in 30 days
- 2Countries
Newest trials
All recruiting trials (54)
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Using contrast-enhanced ultrasound to check for local pancreatic cancer recurrence after surgery
This pilot test uses contrast-enhanced ultrasound to see if it can help detect return of pancreatic cancer after surgery in patients being watched with CT scans.
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Urine VOC Test to Detect Lung Cancer in Never Smokers
A urine test that looks for volatile compounds is tested to see if it can help detect lung cancer in adults who have never smoked.
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VYVGART Hytrulo in stiff person syndrome
This trial tests VYVGART Hytrulo versus placebo in adults with stiff person syndrome who have not fully benefited from IVIg or rituximab.
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Early detection of respiratory impairment in ALS using breathing, MRI, and blood markers
This study tests whether breathing patterns, MRI changes in the brainstem and spinal cord, and blood markers can reveal early ALS signs, especially in people with genetic risk or early symptoms.
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Tai Chi for joint pain relief in women on aromatase inhibitors
This pilot study tests whether a Tai Chi program called TaiChi4Joint can help reduce AI-induced arthralgia in postmenopausal women with hormone receptor-positive breast cancer.
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BMS-986368 for post-stroke spasticity in adults
This trial tests whether the drug BMS-986368 can help reduce spasticity after stroke in adults.
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Ultrasound-Triggered Microbubbles Plus Antibiotics for Knee Infections after Joint Replacement
This study tests whether adding ultrasound-activated microbubbles with antibiotics to the standard revision surgery for knee infections can lower re-infection rates.
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International registry of spinal dural arteriovenous fistula outcomes
This registry will collect treatment and outcome data from people with spinal dural arteriovenous fistulas to see which treatments and factors relate to recovery.
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Tai Chi, alpha-lipoic acid, and acupuncture to reduce chemotherapy-related peripheral neuropathy in people treated for gastrointestinal cancers.
This 16-week pilot will try virtual Tai Chi/Qi Gong or alpha-lipoic acid, adding acupuncture for those who don't improve, to see if these approaches reduce chemo-related nerve numbness and tingling in people treated for GI cancers.
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Pembrolizumab with ultrasound-induced microbubble cavitation for recurrent or metastatic head and neck cancer
We will try giving pembrolizumab together with ultrasound-triggered microbubbles to people with HPV-negative recurrent or metastatic head and neck cancer to help the drug reach tumors and improve response.
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How social factors relate to inflammation in women with breast cancer.
This pilot will try to link social and economic factors to blood markers of inflammation in women newly diagnosed with breast cancer who have not yet started treatment.
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Contrast-enhanced ultrasound to monitor soft tissue sarcoma during neoadjuvant radiation
This pilot will try contrast-enhanced ultrasound with Definity in adults with localized soft tissue sarcoma who are receiving pre-surgery radiation to see if it can guide radiation planning and predict treatment response.
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Self-help ACT toolkit for adults with cystic fibrosis
This test tries a smartphone self-help version of Acceptance and Commitment Therapy (ACT) to reduce anxiety and depression and improve psychological flexibility for adults living with cystic fibrosis.
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GUCY2C prime-boost vaccine for advanced colorectal and small bowel adenocarcinomas
This trial will try a two-step GUCY2C vaccine approach (an adenovirus prime followed by two Listeria-based boosts) in adults with advanced colorectal or small bowel adenocarcinomas that have progressed after standard treatments.
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Radiotherapy for Moderate to Severe Hidradenitis Suppurativa in the Axilla
This study tests whether high-dose radiotherapy to one armpit can reduce lesions and improve symptoms in adults with treatment-resistant hidradenitis suppurativa.
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Arterial compliance and response to intra-aortic balloon counterpulsation in cardiogenic shock
This project will see if baseline arterial compliance (stroke volume/pulse pressure) predicts which adults in cardiogenic shock benefit from intra-aortic balloon counterpulsation.
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CHW4CervixHealth: HPV self-collection kits with community health workers
This project will test whether giving self-collection HPV kits during community workshops led by community health workers helps increase screening among under-screened women aged 25–65 and will first compare kit results to clinical Pap smears.
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Ureteral stent versus no stent for adults having radical cystectomy with an ileal conduit
This trial tests whether placing temporary ureteral stents at the time of radical cystectomy with ileal conduit reduces post-operative complications compared with not placing stents in adults having cystectomy for bladder or other pelvic cancers.
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Lowering opioid use before spine surgery
This pilot test tries two tapering approaches for adults who take daily opioids and have spine surgery scheduled at least four weeks away—education alone versus education plus two CBT sessions—to see which helps them reduce opioids by the time of surgery.
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Mozobil (plerixafor) to mobilize stem cells for autologous transplant
This trial will test whether starting with G‑CSF and giving Plerixafor only when needed can collect enough stem cells for adults with multiple myeloma or lymphoma undergoing autologous transplant while possibly lowering engraftment syndrome.
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Continuous glucose monitoring versus finger‑stick checks in pregnancy with type 2 diabetes
This trial tests whether wearing a continuous glucose monitor helps pregnant people with type 2 diabetes keep up with blood sugar checks more than traditional finger‑stick testing.
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Using contrast-enhanced ultrasound to check Y-90 radioembolization response in liver cancer
This will test whether contrast-enhanced ultrasound (CEUS) can show treatment response to Y‑90 radioembolization in people with newly diagnosed hepatocellular carcinoma who are scheduled for TARE.
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Non-invasive breathing therapies to improve respiratory function after chronic spinal cord injury
We will try combining non-invasive spinal electrical stimulation and brief high-carbon-dioxide breathing with respiratory resistance exercises to see if they improve breathing in adults with chronic incomplete spinal cord injury.
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Blood transfusions at home
This pilot tests whether giving required blood transfusions at home works well and is acceptable for adults with transfusion-dependent blood cancers or bone marrow failure who receive care at SKCCC.
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Registry for COPD patients undergoing lung cancer screening
This study looks at people with COPD who are getting screened for lung cancer to see how their condition affects their screening results and overall health.
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Advanced imaging techniques for understanding idiopathic intracranial hypertension
This study is testing advanced imaging techniques on patients with stubborn idiopathic intracranial hypertension to see how stenting affects their brain fluid flow and overall condition.
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Using an educational video to improve understanding and confidence in thyroid surgery
This study tests if watching a short video about thyroid surgery can help people with thyroid nodules feel more confident and satisfied compared to just getting information from their doctor.
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Rivaroxaban in breast milk after maternal dosing
This will test how much rivaroxaban passes into breast milk in postpartum people taking either prophylactic (10 mg) or therapeutic (20 mg) doses.
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Daily versus split-dose aspirin in high-risk pregnancies
This test compares taking aspirin 162 mg once daily versus 81 mg twice daily to see which dosing better prevents preeclampsia and preterm birth in people with high-risk singleton pregnancies who start aspirin before 16 weeks.
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Evaluating uterine fibroids using ultrasound techniques before and after treatment
This study is testing if a special ultrasound can help women with uterine fibroids see how their condition changes before and after a specific treatment called uterine artery embolization.
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Improving communication about diagnostic uncertainty in the emergency department
This study is testing a new way to help doctors talk to patients about unclear diagnoses when they leave the emergency room to see if it can reduce confusion and prevent them from coming back.
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Tebentafusp plus liver-directed therapy for metastatic uveal melanoma
This trial tests whether combining tebentafusp with liver-directed treatments helps HLA-A*02:01-positive adults with metastatic uveal melanoma keep their liver tumors from growing.
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Comparing strict and permissive thresholds for treating gestational diabetes
This study is testing whether treating gestational diabetes with stricter or more relaxed blood sugar targets leads to better health outcomes for mothers and their babies.
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Comparing strict and permissive thresholds for treating gestational diabetes
This study tests whether starting treatment for gestational diabetes with stricter or more relaxed rules leads to better health outcomes for moms and their babies.
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Using tebentafusp before surgery to shrink large, unresectable uveal melanoma
This trial will try giving tebentafusp before surgery to see if it can shrink large, unresectable primary uveal melanoma in patients who are HLA-A*02:01 positive.
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Using ultrasound to assess liver tumor treatment response
This study is testing if using a special ultrasound during liver cancer treatment can help doctors see how well the treatment is working sooner than traditional imaging methods.
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Cervical cerclage for preventing premature birth in high-risk pregnancies
This study is testing if a procedure called cervical cerclage can help prevent early birth in pregnant people who are at high risk due to a short cervix.
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Evaluating heart damage from radiation in lung and esophageal cancer patients
This study is testing how radiation treatment for lung and esophageal cancer affects the heart and aims to find ways to reduce heart damage during therapy.
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Increasing Lung Cancer Screening for Smokers
This study is testing whether teaching doctors and patients about lung cancer screening can help more smokers get screened for the disease.
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Using contrast-enhanced ultrasound to diagnose recurrent kidney cancer after treatment
This study is testing if a special type of ultrasound can better detect kidney cancer that comes back after treatment compared to regular imaging methods like CT and MRI.
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Combining new drugs with chemotherapy for relapsed or refractory acute myeloid leukemia
This study is testing if adding new drugs, palbociclib or tazemetostat, to standard chemotherapy can help people with relapsed or refractory acute myeloid leukemia feel better and fight their cancer more effectively.
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Peer genetic coaching for African American men with metastatic prostate cancer
This study tests whether having trained peer coaches can help African American men with metastatic prostate cancer understand and access genetic testing better.
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Surgical order of blood vessel division and circulating tumor DNA after lung cancer surgery
This compares doing the pulmonary vein first versus the pulmonary artery first during lung cancer surgery to see if it lowers circulating tumor DNA in adults with stage I–III non-small cell lung cancer.
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Peer navigation to support African American men with metastatic prostate cancer during genetic testing
This trial tests whether a trained peer navigator helps African American men with metastatic prostate cancer better understand and complete genetic testing compared with standard care.
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Noninvasive method to estimate portal hypertension using ultrasound
This study is testing a new ultrasound method to see if it can accurately measure pressure in the liver for people with liver diseases and portal hypertension.
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Time restricted eating for patients with HER2 negative breast cancer undergoing chemotherapy
This study is testing if following a time-restricted eating schedule can help women with HER2 negative breast cancer feel better and respond better to chemotherapy.
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Using virtual reality to improve head and neck cancer surgery
This study is testing if using virtual reality during surgery can help improve outcomes for patients with head and neck cancer.
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Reduced-intensity conditioning to lower treatment-related mortality in stem cell transplant patients
This study is testing a new way to prepare patients for a stem cell transplant to see if it can lower the risk of serious treatment-related complications.
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Caloric restriction combined with targeted radiation therapy for early stage breast cancer
This study is testing if cutting calories while getting targeted radiation therapy can help reduce tumor size more in people with early stage breast cancer compared to just the radiation alone.
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Intravenous iron therapy for anemia in pregnant women
This study tests whether getting iron through an IV works better than taking iron pills for treating anemia in pregnant women.
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Comparing Upper Airway Stimulation and CPAP for Sleep Apnea
This study is testing whether a new treatment called Upper Airway Stimulation works better than the standard CPAP machine for people with obstructive sleep apnea.
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Collection of breast cancer tissue and blood samples
This study is collecting breast cancer tissue and blood samples from patients during surgery to help with future research on the disease.
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Improving how patients take oral cancer medicines with extra education and support
This program tests whether adding enhanced education and material support helps adults with advanced cancers and low health literacy take their oral cancer medicines as prescribed.
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Evaluating brain function in patients with multiple brain tumors treated with targeted radiation
This study is testing whether a specific type of radiation treatment for multiple brain tumors helps patients keep their thinking skills and quality of life better than another type of radiation.
NIH-funded research (newest 40 of 336)
Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.
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Understanding CAG repeat instability in Huntington’s disease
A Huntington’s disease study explores why the CAG repeat in the HTT gene becomes unstable and leads to earlier disease, aiming to uncover factors that influence when and how the disease starts.
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Noninvasive portal pressure estimation using ultrasound-based subharmonic signals
A noninvasive ultrasound method to estimate portal vein pressure in adults with cirrhosis to help manage varices and ascites.
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Twice-reading RNA sequencing to better map RNA modifications
Researchers are using a novel method to read RNA twice to more accurately map chemical modifications in human transcripts, which could help us understand health and disease.
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Improving HIV Prevention for Women in ObGyn Care
Aimed at helping women in obstetric/gynecologic care reduce their risk of HIV by making PrEP and risk–screening more accessible and acceptable.
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Immunostimulatory short non-coding RNAs and lupus
A study in people with lupus looks at tiny RNA pieces that may spark inflammation, to understand if they drive disease activity.
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Global Network for Women’s and Children’s Health: New Cycle Leadership and Collaboration
A long-standing collaboration between TJU and JNMC is expanding to lead and coordinate efforts to improve the health of mothers and young children in low-resource settings.
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Breastfeeding Education Support Tool for Baby
A community-based program in India trains mothers with peer counselors and a mobile app to support exclusive breastfeeding for 6 months and promote healthy growth and development.
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Shared-care program to better coordinate cancer and chronic disease care for underserved patients
This program connects oncologists and primary care doctors to improve care for people newly treated for breast, gastrointestinal, or blood cancers who also have other chronic health conditions.
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Understanding how cells recycle mitochondria with their own DNA
Scientists are studying how cells quietly remove mitochondria that contain their own DNA, a process that could influence cancer biology and cell health.
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Metabolic-ISR Pathway in C9orf72 ALS/FTD and Potential Treatments
A study exploring how brain energy stress and the ISR pathway connect to a common ALS/FTD gene change, with the goal of finding new ways to help people with these conditions.
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Molecular and cellular rules that limit synapse growth in smell circuits
Scientists are studying how smell circuits in the brain form the right number of connections to work well, which could help understand diseases that affect thinking and memory.
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Ultrasound-Activated Antibiotics to Prevent Spinal Infections
A new method uses ultrasound to release antibiotics directly at spinal hardware to help prevent infections after spine surgery.
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Dual-Action Anti-tick Vaccine to Protect People and Pets
A new vaccine aims to help protect people and animals from tick-borne diseases by targeting tick neuron ion channels to kill ticks.
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Molecular factors controlling how short immune-stimulating RNAs are made and released
Researchers are studying tiny RNA molecules that help the immune system respond to infections, with a new method to detect these RNAs more completely.
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A measles-based vaccine to protect children from rabies
A new, affordable measles-vectored vaccine is being developed to help prevent rabies in children, especially in places where dog bites are common.
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How a nutrient transporter in immune cells helps fight bacterial infections
A researcher plans to study how a specific nutrient transporter in dendritic cells supports anti-bacterial defenses and immune signaling.
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Cytoskeleton tricks by Chlamydia in infection
This grant studies how the sexually transmitted bacterium Chlamydia trachomatis changes the inside of human cells to survive and grow, with potential to inform new ways to prevent disease.
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Contrast-enhanced Ultrasound to Better Characterize Indeterminate Ovarian Lesions
A multicenter study tests a new ultrasound tool that uses contrast and AI-ready analysis to more accurately tell if ovarian lesions are cancerous in women with uncertain findings.
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Understanding ADHD Stimulant Use and Teen Substance Outcomes
A long-term study following adolescents with ADHD to see how different patterns of stimulant treatment relate to later substance use risks and outcomes.
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Second-Generation Stat5 Inhibitors to Fight Prostate Cancer
A new drug candidate is being developed to block Stat5 signaling in prostate cancer that has stopped responding to standard hormone therapy.
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NSD2-NEO1 pathway and CNS spread of childhood ALL
A pediatric leukemia study looks at how a gene mutation helps leukemia cells reach the brain, with the aim of finding targeted, less toxic treatments.
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Mitochondria-meets-phagosomes: how cell powerhouses help dendritic cells fight infections
A short project will explore how mitochondria and phagosomes talk to each other in dendritic cells to support immune defense against bacteria.
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Targeting serotonin receptors to boost a cancer cell weakness in uveal melanoma
A small funding project tests whether blocking the serotonin HTR2B receptor can weaken mutant GNAQ/GNA11-driven uveal melanoma cells to help fight metastatic eye cancer.
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Tailored postpartum care strategies to improve maternal health
A real-world study tests a customized set of postpartum care practices led by community partners to improve new mothers' health and safety.
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CONNECT: Multilevel support to help women stick with endocrine breast cancer therapy
A study at Thomas Jefferson University aims to help women with hormone receptor–positive breast cancer stay on endocrine therapy longer by combining navigation, social connections, and smart monitoring.
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Understanding how Wnt signaling works in diseases like cancer and heart disease
A research team will study how two proteins (LRP5/6) control a key cell communication pathway that affects cancer and heart-related conditions, with the goal of finding new ways to influence this pathway in patients.
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Targeted EHR-based Communication of Diagnostic Uncertainty in the ED
A patient-facing project that uses the electronic health record to help doctors talk with ED patients about uncertainty when a diagnosis isn’t final yet.
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DNA-PK inhibitors to reduce HIV gene expression
A patient-focused project to test whether a DNA-PK inhibitor can safely reduce HIV RNA and proteins in people living with HIV who are on ART.
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Layer-specific brain signals tied to perception and learning
A study using advanced brain imaging (VASO fMRI) aims to map how information moves across brain layers during perception and learning in adults.
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Targeting GPRC5A and GPRC5B in airway smooth muscle for asthma therapy
Researchers are testing new targets in airway smooth muscle to help people with asthma breathe more easily and reduce airway remodeling.
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Diacylglycerol kinase and airway muscle function in asthma
Aims to understand how a specific enzyme (DAG kinase) controls how airway muscles behave in asthma, with the goal of better treatments.
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ABCC1 and beta2-adrenergic signals in airway smooth muscle
A study to understand how a transporter protein ABCC1 affects howAirway smooth muscle relaxes in response to beta2-adrenergic medicines for asthma.
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Biased beta-2 receptor boosters to improve airway muscle function
A NIH grant aims to find small molecules that enhance beneficial beta-2 receptor signals in airway smooth muscle to help manage asthma.
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Human airway muscle samples and tissues hub for asthma research
A funded NIH grant will provide standardized human airway smooth muscle cells and lung tissue samples to study what drives airway tightening and relaxation in asthma.
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Role of a cellular pathway in ALS/FTD and Alzheimer’s disease-related dementias
A study from Thomas Jefferson University is exploring how a specific cell-signaling pathway might drive brain cell death in ALS, FTD and Alzheimer’s-related dementias and could point to new ways to help patients.
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Discovery/Signaling Core supports new bronchodilation discoveries
A collaboration at Thomas Jefferson University aims to find new small molecules and molecular insights to help relax narrowed airways in asthma and other airway diseases.
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Administrative core for a translational program improving asthma research collaboration
This grant funds an Administrative Core to coordinate funds, communication, and data quality for a multi-institution asthma-focused program.
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GPCR-based approaches to better treat asthma
A multi-project program explores new GPCR targets and molecules to improve how the airways contract and respond in asthma, with plans to test promising ideas in models and animals.
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Ways to help platelets balance bleeding risk in coagulation disorders
A research grant aims to understand how to boost platelet function to prevent excessive bleeding in people with clotting disorders.
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2D and 3D Ultrasound to Improve Chemoembolization in Liver Cancer
A patient-friendly look at using advanced ultrasound to better guide chemoembolization for liver cancer and ensure fewer repeat procedures.
Quick answers
How many clinical trials run by Thomas Jefferson University are recruiting right now?
54, as of November 12, 2026. 2 of them were first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.
Where are these trials running?
In 2 countries. The most sites are in United States (54 trials), Switzerland (1 trial). Each study page lists its sites and which ones are recruiting.
What phases are they in?
Phase 2: 9, Phase 1: 4, Phase 1/2: 2, Early Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.
How do I join one?
Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.
Find the studies that fit you
A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.