GPCR-based approaches to better treat asthma
Official title: Exploiting emerging ideas in G protein-coupled receptor biology and pharmacology to treat asthma
Funded at Thomas Jefferson University · NIH-11417182 · Data updated 2026-11-12
A multi-project program explores new GPCR targets and molecules to improve how the airways contract and respond in asthma, with plans to test promising ideas in models and animals.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Thomas Jefferson University NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | September 20, 2025 |
| Project end | July 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $2,325,263 |
| NIH project number | 5P01HL180318-02 |
| Project ID | NIH-11417182 on NIH RePORTER |
Who could benefit from this research
✓Could help
People with asthma who could benefit from new GPCR-targeted therapies, particularly those with severe or poorly controlled symptoms.
✕Less likely to help
Patients whose asthma does not involve pathways targeted by GPCR regulation or who do not respond to the specific mechanisms studied may not benefit.
What this research studies
This program brings together experts in GPCR biology and asthma to find new targets that control airway smooth muscle contraction and growth. It will explore how novel GPCR-targeting molecules affect airway function and the mechanisms behind their effects. The work spans multiple projects, cores, and in vivo asthma models to assess the therapeutic potential of these new targets. The aim is to identify treatments that offer better control of asthma symptoms by modulating airway muscle behavior.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that more effectively relax and regulate airway muscle, potentially reducing asthma symptoms and improving quality of life.
How similar studies have gone: Previous work in GPCR biology has shown promise in regulating airway function, supporting further exploration in asthma.
Where this research is happening
-
Thomas Jefferson University
Philadelphia, United States Active
Researchers
- Principal investigator: Penn, Raymond B. — Thomas Jefferson University
- Study coordinator: Penn, Raymond B.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.