Contrast-enhanced Ultrasound to Better Characterize Indeterminate Ovarian Lesions
Official title: Contrast-enhanced Ultrasound Evaluation of Indeterminate Ovarian Lesions: Prospective Multicenter Study
Funded at Thomas Jefferson University · NIH-11449027 · Data updated 2026-11-12
A multicenter study tests a new ultrasound tool that uses contrast and AI-ready analysis to more accurately tell if ovarian lesions are cancerous in women with uncertain findings.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Thomas Jefferson University NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | July 1, 2026 |
| Project end | June 30, 2031 |
| Funding year | 2026 |
| Award (this year) | $671,674 |
| NIH project number | 1R01CA308347-01A1 |
| Project ID | NIH-11449027 on NIH RePORTER |
Who could benefit from this research
✓Could help
Women with indeterminate ovarian lesions identified on initial imaging.
✕Less likely to help
Patients with clearly benign or clearly malignant lesions may not need this additional testing.
What this research studies
This project will enroll women with indeterminate ovarian lesions to see if contrast-enhanced ultrasound with new quantitative features can reliably distinguish malignant from benign lesions. The study emphasizes consistency across examiners by measuring inter-reader reliability and reproducibility of CEUS biomarkers with repeated injections. It also introduces advanced, AI-informed statistical features to improve lesion categorization. If validated, this approach could lead to earlier, safer, and less costly diagnoses compared with current methods.
Why it matters
Potential benefit: If successful, patients may receive more accurate, faster diagnoses and better-informed treatment decisions.
How similar studies have gone: Prior CEUS work suggests promise, but this study seeks prospective validation and AI-based enhancements.
Where this research is happening
-
Thomas Jefferson University
Philadelphia, United States Active
Researchers
- Principal investigator: Lyshchik, Andrej — Thomas Jefferson University
- Study coordinator: Lyshchik, Andrej
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.