Tai Chi for joint pain relief in women on aromatase inhibitors

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This nonrandomized pilot randomized trial compares TaiChi4Joint, a virtual Tai Chi program, with a health education attention control in women with stage I-III hormone receptor-positive breast cancer who are on an aromatase inhibitor and experience joint pain. Participants are randomized 1:1 to 12 weeks of online Tai Chi classes or health education, with assessments at baseline, after the program, and 2 months later. The study aims to assess feasibility and acceptability and to pilot data collection for biome behavioral mechanism measures. Eligible participants are postmenopausal adults on AI therapy within 5 years of initiation, reporting moderate joint pain, and able to complete procedures in English.

Why it matters

Who can join: the full rules

Inclusion Criteria:

-Individuals must meet all the following inclusion criteria in order to be eligible to participate in the study:

* Age ≥18 years
* Diagnosis of stage I-III hormone receptor-positive breast cancer
* Postmenopausal
* Currently receiving an aromatase inhibitor (anastrozole, letrozole, or exemestane) or within 5 years of initiation
* Report joint pain that started or worsened after initiation of AI therapy
* Report worst pain in the past week ≥3 on the BPI (0-10 scale)
* Able to complete study procedures in English
* Willing to be randomized to an intervention or attention control group and adhere to study procedures

Exclusion Criteria:

-An individual who meets any of the following criteria will be excluded from participation in this study:

* Undergoing active cancer treatment (excluding endocrine therapy)
* Uncontrolled cardiac or pulmonary disease that would limit safe participation
* Currently engaged in regular structured moderate- or vigorous-intensity exercise (e.g., brisk walking, jogging/running, cycling, swimming, aerobic classes, or resistance training) totaling ≥150 minutes per week over the past 3 months
* Currently participating in Tai Chi, yoga, Pilates, or other structured mind-body practice ≥2 times per week over the past 3 months
* Joint pain due to inflammatory arthritic conditions
* Recent surgery or joint injection within the past 4-6 weeks
* Initiation or dose change of corticosteroids or opioids within the past 4 weeks
* Planned discontinuation of AI therapy within the next 6 months
* This study is limited to women with breast cancer, as \<1% of cases occur in men and data on AIIA in male patients are limited

Where it's running

• Sidney Kimmel Cancer Center at Thomas Jefferson University
  Philadelphia, Pennsylvania, United States Recruiting

Study contacts

• Principal investigator: Kuang-Yi Wen, PhD — Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
• Study coordinator: Kuang-Yi Wen, PhD
• Email: Kuang-Yi.Wen@Jefferson.edu
• Phone: 215-503-4623

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.