ABCC1 and beta2-adrenergic signals in airway smooth muscle
Official title: ABCC1 mediates b2AR effects on excitation-contraction (E-C) coupling of human airway smooth muscle
Funded at Thomas Jefferson University · NIH-11417202 · Data updated 2026-11-12
A study to understand how a transporter protein ABCC1 affects howAirway smooth muscle relaxes in response to beta2-adrenergic medicines for asthma.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Thomas Jefferson University NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | September 20, 2025 |
| Project end | July 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $332,180 |
| NIH project number | 5P01HL180318-02 |
| Project ID | NIH-11417202 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with asthma or airway symptoms who could contribute tissue samples or be considered for future trials.
✕Less likely to help
People without asthma or who cannot provide or consent to tissue samples may not directly benefit from this study.
What this research studies
This project looks at how ABCC1 influences the way airway smooth muscle responds to beta2-adrenergic drugs, which are commonly used to treat asthma. Researchers will test how ABCC1 activity changes intracellular cAMP levels and muscle relaxation, and whether CK2 and MAPK pathways modify ABCC1’s role. The work will involve examining human airway smooth muscle samples and relevant cellular models to map the signaling steps from receptor activation to muscle relaxation. The findings could reveal new ways to improve asthma therapies by targeting ABCC1-related pathways. The study spans lab experiments over several years to test the central hypothesis and aims.
Why it matters
Potential benefit: If successful, the research could lead to enhanced asthma treatments that make beta2-agonists more effective.
How similar studies have gone: Prior work showed ABCC1 involvement in cAMP handling and airway relaxation, supporting potential translational relevance.
Where this research is happening
-
Thomas Jefferson University
Philadelphia, United States Active
Researchers
- Principal investigator: Panettieri, Reynold Alexander — Thomas Jefferson University
- Study coordinator: Panettieri, Reynold Alexander
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.