Improving how patients take oral cancer medicines with extra education and support

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized controlled trial at Albert Einstein Healthcare Network compares standard nurse-delivered education to an enhanced intervention combining simplified, tailored education and material supports to improve adherence to oral anticancer agents. Eligible participants are adults with a range of metastatic solid tumors or hematologic malignancies who are prescribed oral chemotherapy or targeted therapies and have ECOG performance status under 3. Adherence will be tracked over time using patient report and clinic-based monitoring, and the study will examine changes in medication-taking behavior and engagement with care. The program is designed specifically for a medically underserved, low-literacy urban population to produce practical, implementable interventions.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* All patients on oral chemotherapeutic agents
* Clinical diagnosis of stage IV breast cancer
* Clinical diagnosis of stage III and IV colorectal cancer (not receiving concurrent radiation therapy)
* Clinical diagnosis of stage IV non-small cell lung cancer
* Clinical diagnosis of stage IV renal cell carcinoma
* Clinical diagnosis of stage IV ovarian carcinoma
* Clinical diagnosis of multiple myeloma
* Clinical diagnosis of chronic myelogenous leukemia on TKI
* Clinical diagnosis of myelodysplastic syndrome on Lenalidomide
* Adjuvant treatment for Gastro Intestinal Stromal Tumor
* Clinical diagnosis of chronic Lymphocytic Leukemia
* Clinical diagnosis of metastatic Prostate cancer
* Clinical diagnosis of hepatocellular Carcinoma
* Clinical diagnosis of stage IV Melanoma
* Clinical diagnosis of myelofibrosis/myeloproliferative neoplasms
* Age \>18 years
* ECOG Performance Status \<3

Exclusion Criteria:

* ECOG Performance Status of 3 and above
* Concurrent chemo radiation
* Non-English speaker
* Clinical diagnosis of dementia, or otherwise unable to give informed consent.
* History of non-compliance (defined as the history of 2 or more missed appointments in the clinic).
* Pregnant patients
* Nursing Home Patients
* Incarcerated

Where it's running

• Albert Einstein Healthcare Network
  Philadelphia, Pennsylvania, United States Recruiting

Study contacts

• Principal investigator: Claudia M Dourado, MD — Thomas Jefferson University
• Study coordinator: Claudia M Dourado, MD
• Email: Douradoc@einstein.edu
• Phone: 215-456-3880

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.