Ways to help platelets balance bleeding risk in coagulation disorders
Official title: Integration of platelets and coagulation to maintain hemostasis in vivo
Funded at Thomas Jefferson University · NIH-11403844 · Data updated 2026-11-12
A research grant aims to understand how to boost platelet function to prevent excessive bleeding in people with clotting disorders.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Thomas Jefferson University NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | September 5, 2025 |
| Project end | May 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $448,364 |
| NIH project number | 5R01HL176891-02 |
| Project ID | NIH-11403844 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are patients with inherited or acquired bleeding disorders where platelet activation and thrombin generation are impaired.
✕Less likely to help
Patients whose bleeding is not related to platelet signaling or who have conditions not responsive to this approach may not benefit.
What this research studies
This project looks at how platelets and the body's clotting system work together to stop bleeding, with a focus on patients who have impaired coagulation. Researchers will study the signals inside platelets that limit their activity and test whether tweaking these signals can strengthen the formation of a stable clot. The work will use laboratory experiments and disease models to see if reducing negative regulators can improve hemostasis without raising clot risks. If successful, the approach could lead to new treatments that complement or replace some current therapies for bleeding disorders.
Why it matters
Potential benefit: It could lead to safer, more effective ways to prevent and control bleeding for people with coagulation disorders.
How similar studies have gone: Previous work shows that modifying platelet signaling can influence bleeding in models of coagulation disorders, supporting further exploration.
Where this research is happening
-
Thomas Jefferson University
Philadelphia, United States Active
Researchers
- Principal investigator: Stalker, Timothy J. — Thomas Jefferson University
- Study coordinator: Stalker, Timothy J.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.