Evaluating uterine fibroids using ultrasound techniques before and after treatment

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to assess the vascular patterns of uterine fibroids before and after uterine artery embolization (UAE) using contrast-enhanced ultrasound (CEUS). The goal is to provide a cost-effective, non-invasive alternative to gadolinium-enhanced MRI, which has more contraindications and side effects. Additionally, the study will analyze uterine fibroid pressures using SHAPE technology to identify differences between fibroid and normal myometrium tissue, potentially leading to new biomarkers for diagnosis and treatment. The study involves female participants diagnosed with endometrial cancer who are scheduled for UAE.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Be a female diagnosed with endometrial cancer and scheduled for UAE.
* Be over the age of 18 years.
* If the subject is of child-bearing potential, must have a negative pregnancy test.
* Be conscious and able to comply with study procedures.
* Have read and signed the IRB approved consent form for participating in the study.

Exclusion Criteria:

* Females who are pregnant or nursing.
* Patients who have received an investigational drug in the 30 days before study drug administration, or will receive one within 72 hours afterwards.
* Patients who are medically unstable, patients who are seriously or terminally ill, and patients whose clinical course is unpredictable. For example:
* Patients on life support or in a critical care unit.
* Patients with clinically unstable cardiac arrhythmias, such as recurrent ventricular tachycardia.
* Patients with recent cerebral hemorrhage.
* Patients who have undergone surgery within 24 hours prior to the study sonographic examination.
* Patients with congenital heart defects.
* Patient with a known allergy to Definity.

Where it's running

• Thomas Jefferson University
  Philadelphia, Pennsylvania, United States Recruiting

Study contacts

• Study coordinator: Priscilla Machado, MD
• Email: priscilla.machado@jefferson.edu
• Phone: 215-955-4279

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Registry for pregnancy outcomes after Exablate treatment for uterine fibroids

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.