Cytoskeleton tricks by Chlamydia in infection
Official title: Regulation of cytoskeletal reorganization by Chlamydia
Funded at Thomas Jefferson University · NIH-11450002 · Data updated 2026-11-12
This grant studies how the sexually transmitted bacterium Chlamydia trachomatis changes the inside of human cells to survive and grow, with potential to inform new ways to prevent disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Thomas Jefferson University NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | September 3, 2026 |
| Project end | August 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $558,367 |
| NIH project number | 1R01AI195642-01A1 |
| Project ID | NIH-11450002 on NIH RePORTER |
Who could benefit from this research
✓Could help
People with or at risk for Chlamydia infections, including those affected by ocular or genital infection.
✕Less likely to help
Results may not directly benefit individuals without Chlamydia infection or risk factors.
What this research studies
Chlamydia trachomatis lives inside human cells and builds a protective scaffold around its hiding spot, the inclusion. The project aims to map how the bacterium reshapes the cell’s skeleton and which steps are needed for its development inside the host. By identifying key proteins and pathways that Chlamydia uses to form these scaffolds, the research may point to new targets for therapies or vaccines. The work combines cell biology, molecular studies, and in vivo analysis to understand how these cytoskeletal changes influence disease progression. The ultimate goal is to better prevent bacterial sexually transmitted infections and the related complications.
Why it matters
Potential benefit: Findings could lead to new strategies to prevent or treat Chlamydia infections and its serious complications.
How similar studies have gone: Previous studies have identified InaC and cytoskeletal changes as important factors in Chlamydia development, suggesting this approach has merit but remains an active area of discovery.
Where this research is happening
-
Thomas Jefferson University
Philadelphia, United States Active
Researchers
- Principal investigator: Paumet, Fabienne Michelle — Thomas Jefferson University
- Study coordinator: Paumet, Fabienne Michelle
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.