Layer-specific brain signals tied to perception and learning
Official title: Understanding layer-specific contributions to perception and learning in human cortex
Funded at Thomas Jefferson University · NIH-11419243 · Data updated 2026-11-12
A study using advanced brain imaging (VASO fMRI) aims to map how information moves across brain layers during perception and learning in adults.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Thomas Jefferson University NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | September 30, 2025 |
| Project end | August 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $249,000 |
| NIH project number | 5R00EY034169-03 |
| Project ID | NIH-11419243 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults 21 years or older without acute neurological or psychiatric conditions that would interfere with MRI.
✕Less likely to help
People with certain MRI-incompatibilities or severe claustrophobia may not benefit from participation.
What this research studies
This project will examine how feedforward signals from early sensory areas and feedback from higher brain regions are organized across cortical layers in people performing cognitive tasks. Using the cutting-edge vascular space occupancy fMRI method, researchers will study layer-specific brain activity in adults beyond primary sensory areas. They plan to validate layer-fMRI findings by linking layer-specific changes to behavior and cognition, and map which layers carry feedforward versus feedback information. The work could deepen our understanding of how complex thoughts and learning emerge from layered brain circuits.
Why it matters
Potential benefit: If successful, this research could improve our understanding of cognitive disorders and guide better treatments that target brain circuitry.
How similar studies have gone: Previous layer-fMRI work has shown promising links between layered activity and cognition, but this study extends validation to higher-order cortex and behavior.
Where this research is happening
-
Thomas Jefferson University
Philadelphia, United States Active
Researchers
- Principal investigator: Persichetti, Andrew S — Thomas Jefferson University
- Study coordinator: Persichetti, Andrew S
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.