Advanced imaging techniques for understanding idiopathic intracranial hypertension

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study focuses on patients with refractory idiopathic intracranial hypertension (IIH) who are scheduled to undergo venous sinus stenting. It aims to evaluate advanced neuroimaging metrics, particularly using MRI and diffusion tensor imaging, to gain insights into the pathophysiology of IIH and the effects of stenting on glymphatic function. By assessing cerebrospinal fluid dynamics and venous outflow, the study seeks to identify potential surrogate markers that could enhance understanding and treatment of IIH. The research will be conducted at the Jefferson Headache Center in Philadelphia, Pennsylvania.

Why it matters

Who can join: the full rules

Inclusion Criteria:

• Refractory IIH patients who require and plan to have a venous sinus stenting

Exclusion Criteria:

* History of head trauma and shunting or leak repair
* Major concurrent, active non-cephalic pain syndrome
* Contradictions for MRIs

Where it's running

• Jefferson Headache Center
  Philadelphia, Pennsylvania, United States Recruiting

Study contacts

• Principal investigator: Hsiangkuo Yuan, MD PhD — Thomas Jefferson University
• Study coordinator: Enchao Qiu, MD PhD
• Email: enchao.qiu@jefferson.edu
• Phone: 215-955-1149

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• NAIF 2.0: See if glymphatic flow changes after dAVF treatment

  This study tests whether the brain’s waste-clearance system changes after endovascular treatment for intracranial dural arteriovenous fistulas in adults.

  Recruiting Hospital Universitari Vall d'Hebron Research Institute · Bologna and 2 other locations · NCT07824297

• Sleep and Brain Clearance Test with a Wireless Sleep-Boosting Headband

  This study tests whether a wireless headband that tracks brain activity and delivers gentle stimulation can improve sleep-dependent brain clearance and memory in healthy adults.

  Recruiting University of Washington · Seattle, Washington · NCT07608614

• Bright light therapy to help sleep after brain injury

  This trial tests whether morning bright light therapy can improve sleep and related brain health markers in adults with a traumatic brain injury.

  Recruiting Oregon Health and Science University · Portland, Oregon · NCT07601841

• Tirzepatide for Idiopathic Intracranial Hypertension

  This trial tests whether tirzepatide can help people with idiopathic intracranial hypertension by comparing it to placebo over 12 months.

  Recruiting Phase 4 Duke University · Durham, North Carolina · NCT07191873

• Transverse sinus stenting for people with long-term intracranial hypertension on acetazolamide

  This trial will test whether adding a stent in the narrowed transverse sinus helps adults with idiopathic intracranial hypertension who have been on acetazolamide for over a year but still have symptoms.

  Recruiting University Hospital, Montpellier · Montpellier and 2 other locations · NCT06945848

• Transverse sinus stenting for newly diagnosed idiopathic intracranial hypertension

  This will test whether adding transverse venous sinus stenting to standard medical care helps adults with newly diagnosed idiopathic intracranial hypertension improve vision, headaches, or tinnitus.

  Recruiting University Hospital, Montpellier · Montpellier and 2 other locations · NCT06919744

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.