Advanced imaging techniques for understanding idiopathic intracranial hypertension
Pathophysiological Evaluation of Idiopathic Intracranial Hypertension Using Glymphatic and Connectomic Imaging
This study is testing advanced imaging techniques on patients with stubborn idiopathic intracranial hypertension to see how stenting affects their brain fluid flow and overall condition.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 30 (estimated) |
| Ages | 18 Years to 55 Years |
| Sex | All |
| Sponsor | Thomas Jefferson University Academic / other |
| Locations | 1 site (Philadelphia, Pennsylvania) |
| Trial ID | NCT06950099 on ClinicalTrials.gov |
What this trial studies
This observational study focuses on patients with refractory idiopathic intracranial hypertension (IIH) who are scheduled to undergo venous sinus stenting. It aims to evaluate advanced neuroimaging metrics, particularly using MRI and diffusion tensor imaging, to gain insights into the pathophysiology of IIH and the effects of stenting on glymphatic function. By assessing cerebrospinal fluid dynamics and venous outflow, the study seeks to identify potential surrogate markers that could enhance understanding and treatment of IIH. The research will be conducted at the Jefferson Headache Center in Philadelphia, Pennsylvania.
Who should consider this trial
Good fit: Ideal candidates for this study are patients with refractory idiopathic intracranial hypertension who are planning to undergo venous sinus stenting.
Not a fit: Patients with a history of head trauma, shunting or leak repair, or those with contraindications for MRIs may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved diagnostic and therapeutic strategies for patients suffering from idiopathic intracranial hypertension.
How similar studies have performed: While the specific approach of using advanced neuroimaging in this context may be novel, similar studies have shown promise in understanding cerebrospinal fluid dynamics and treatment outcomes in related conditions.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: • Refractory IIH patients who require and plan to have a venous sinus stenting Exclusion Criteria: * History of head trauma and shunting or leak repair * Major concurrent, active non-cephalic pain syndrome * Contradictions for MRIs
Where this trial is running
Philadelphia, Pennsylvania
- Jefferson Headache Center — Philadelphia, Pennsylvania, United States (Recruiting)
Study contacts
- Principal investigator: Hsiangkuo Yuan, MD PhD — Thomas Jefferson University
- Study coordinator: Enchao Qiu, MD PhD
- Email: enchao.qiu@jefferson.edu
- Phone: 215-955-1149
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.