Clinical trial Recruiting at 1 site Phase 2 Interventional Ages 18 and up

Using ultrasound to assess liver tumor treatment response

Official title: 2D and 3D Contrast Enhanced Ultrasound of Chemoembolization

Run by Thomas Jefferson University · NCT06261814 · Data updated 2026-11-12

This study is testing if using a special ultrasound during liver cancer treatment can help doctors see how well the treatment is working sooner than traditional imaging methods.

Quick facts

PhasePhase 2
Study typeInterventional
Ages18 Years and up
SexAll
Enrollment266 (estimated)
SponsorThomas Jefferson University
Academic / other
Drugs / interventionschemotherapy
Locations1 site (Philadelphia, Pennsylvania)
StatusRecruiting
StartedAugust 7, 2024
Main results expectedJuly 1, 2027
Study endsJanuary 1, 2028
Registry record updatedFebruary 17, 2026
Trial IDNCT06261814 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are adults scheduled for TACE therapy for liver tumors and who are medically stable.

Probably not a fit

Patients who are medically unstable or have known sensitivities to the components of Lumason may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This phase II trial evaluates the effectiveness of contrast-enhanced ultrasound (CEUS) in determining how well patients with liver tumors respond to transarterial chemoembolization (TACE). The study aims to compare CEUS with traditional imaging methods like MRI and CT, which assess treatment response weeks after TACE. By using CEUS during the TACE procedure, the trial seeks to provide earlier and potentially more accurate evaluations of treatment effectiveness. Patients will receive an imaging agent and undergo CEUS at multiple points: before, during, and after the TACE procedure.

Why it matters

Potential benefit: If successful, this approach could allow for quicker and more accurate assessments of liver tumor treatment responses, leading to timely adjustments in therapy.

How similar studies have gone: While CEUS is a promising technique, its application in this specific context is novel and has not been extensively tested in previous studies.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Scheduled for TACE therapy of a liver tumor
* Be at least 18 years of age
* Be medically stable
* If a female of child-bearing age, must have a negative pregnancy test
* Have signed informed consent to participate in the study

Exclusion Criteria:

* Patients who are medically unstable, patients who are seriously or terminally ill, and patients whose clinical course is unpredictable
* Patients with known sensitivities to the components of lumason

Where it's running

  • Sidney Kimmel Cancer Center at Thomas Jefferson University
    Philadelphia, Pennsylvania, United States
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.