Sponsor or institution
Clinical trials and research at London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
As of November 12, 2026, Find a Trial lists 77 clinical trials run by London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's that are recruiting, at sites in 2 countries (most in Canada (77), Switzerland (2)). 1 was first registered in the last 30 days. By phase: Phase 2 (8), Phase 3 (4), Phase 2/3 (2), Early Phase 1 (1). Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 77Clinical trials
- 1New in 30 days
- 2Countries
Newest trials
All recruiting trials (77)
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Renal Nerve Stimulation to Help Blood Pressure in AF and HFpEF
This study tests whether stimulating the kidneys with a catheter can safely lower blood pressure in adults with atrial fibrillation and HFpEF who also have hypertension.
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Intraoperative diuretics during deceased-donor kidney transplants
This trial tests whether using furosemide or mannitol during kidney transplant surgery affects delayed graft function in adults receiving a deceased-donor kidney.
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Faster brain stimulation for PTSD and depression
This pilot study tests a quicker brain stimulation schedule (accelerated iTBS) to see if it’s doable, safe, and tolerable for adults with PTSD and major depression.
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Bladder Management and Quality of Life in Young Adults with Spina Bifida
This study asks teens and young adults with spina bifida how different bladder care methods affect their daily life and happiness.
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What factors predict delayed behavior problems in children after procedural sedation
This study will test which factors make children aged 1–17 more likely to have delayed behavior problems (such as sleep trouble, anxiety, or aggression) after procedural sedation in emergency departments and dental clinics.
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Gentamicin dosing in neonates: checking if extended-interval dosing still works
This study checks whether extended-interval gentamicin dosing in newborns up to 7 days old still achieves safe and effective drug levels.
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Stereotactic post-operative radiation for head and neck skin squamous cell cancer involving the parotid/neck
This trial tests whether a short, five‑session stereotactic radiation course works as well and has fewer side effects than the usual 20–30 session radiation after surgery for head and neck skin squamous cell carcinoma.
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Focal HDR-BT Boost vs Whole-Gland HDR-BT Boost for Localized Prostate Cancer
This trial tests whether giving a focal high-dose HDR brachytherapy boost to a dominant lesion improves outcomes for men with intermediate- to high-risk localized prostate cancer compared with a whole-gland HDR boost.
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AV-001 to Prevent Brain Injury from Hemodialysis
This study will test whether giving AV-001 before dialysis can protect the brains of adults on regular hemodialysis by strengthening blood vessels and reducing inflammation.
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Oral L-Carnitine for people with heart failure
This study will test whether taking oral L-carnitine can help adults with heart failure (including those with stage 1–4 chronic kidney disease) feel less tired, breathe easier, and improve heart function.
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SBRT with intratumoural pembrolizumab before neoadjuvant chemotherapy for high-risk breast cancer
This study will test whether a short course of focused radiation plus two injections of pembrolizumab into the tumor before chemotherapy helps people with high‑risk invasive breast cancer respond better to treatment.
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Desmopressin (DDAVP) and TEG6s in Heart Surgery Coagulation
This study tests whether giving desmopressin after reversal of heparin helps improve clotting in adults undergoing cardiopulmonary bypass during elective heart surgery.
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Suprazygomatic Maxillary Nerve Block for Kids After Tonsil Removal
This study tests whether giving a SZMN nerve block with or without medicine can reduce pain after tonsil surgery in children.
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Fecal microbiome transplant for restricting-type anorexia nervosa
Researchers will try oral fecal microbiome transplant capsules in people with restricting-type anorexia nervosa to see if changing gut bacteria improves metabolism, immune health, and thinking about food and weight.
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Gut bacteria and knee implants: comparing people with well-functioning vs. revision total knee replacements
This study tests whether the gut microbiome differs between people with a knee replacement that works well and those who need a revision surgery.
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Single versus dual implant fixation for fixing distal femur (lower thigh) fractures in older or medically vulnerable adults
We will randomly assign older or medically vulnerable adults with distal femur fractures to receive either a single implant or a dual implant fixation to see if dual fixation helps them heal and recover better.
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Ultrasound-guided Lead Placement for Left Bundle Branch Area Pacing
We’re testing whether ultrasound guidance can improve placing a pacemaker lead in the left bundle branch area for patients needing a single- or dual-chamber pacemaker.
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Higher-dose, short-course chest radiation that spares the esophagus
This trial will try a five-session, higher-dose, esophagus-sparing radiation schedule for adults with intrathoracic tumors who need palliative chest radiation, compared with standard palliative radiation.
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Exercise before dialysis to protect heart function
This study is testing if doing cycling exercises before dialysis can help protect the heart and improve symptoms for people undergoing hemodialysis.
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Dialysis that removes more middle molecules using super high‑flux filters
This trial will test whether using super high‑flux (expanded) dialysis filters instead of standard high‑flux filters reduces the risk of death and other harms for adults on in‑center hemodialysis who are older or have diabetes.
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Investigating genistein for treating amyloid cardiomyopathy
This study is testing if genistein can safely help people with amyloid cardiomyopathy improve their heart health and exercise ability.
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Improving prognosis for patients with Status Epilepticus
This study is trying to find blood markers that can help predict how well patients with Status Epilepticus will recover in the ICU and how their thinking skills may change after they leave the hospital.
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B2AD-Risk: How atrial fibrillation burden changes after ischemic stroke
This project will try continuous implantable heart-rhythm monitoring to see how atrial fibrillation changes over time in people newly diagnosed with AF after an ischemic stroke.
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Weight-Bearing CT for Healing of Periprosthetic Knee Fractures
This study tests weight-bearing CT scans to better assess healing after distal femur fractures around a knee implant in adults 50–90 years old who recently had revision knee surgery.
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Early chest tube removal after lung surgery
This study tests if taking out chest tubes on the same day after lung surgery can make recovery easier and more comfortable for patients.
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Home monitoring for patients after lung cancer surgery
This study is testing if using digital home monitoring can help lung cancer surgery patients recover better and avoid emergency room visits compared to standard care.
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Mindfulness program for children with Juvenile Idiopathic Arthritis
This study is testing a mindfulness program for kids with Juvenile Idiopathic Arthritis and their caregivers to see if it helps them cope better and feel healthier.
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Biobank of stem cells and biomarkers for cardiovascular disease
This study is creating a bank of stem cells and blood samples from people with heart disease to help researchers learn more about the condition and find better treatments.
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Using genetic testing to personalize treatment for PTSD in veterans
This study is testing if using genetic testing can help personalize mental health treatments for veterans and members of the Canadian Armed Forces and Royal Canadian Mounted Police with PTSD.
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Controlling heart rate in patients with atrial fibrillation using a pacemaker and ablation
This study tests a new way to help people with atrial fibrillation and heart failure by using a pacemaker and a procedure to control their heart rate better.
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Thiosulfate-enhanced kidney preservation for deceased-donor transplants
This trial will test whether adding sodium thiosulfate to the solution used to preserve deceased-donor kidneys helps reduce transplant-related injury and improve early kidney function in adults with end-stage renal disease.
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Comparing standard knee surgery to ROSA-assisted knee surgery
This study is testing if a new robotic-assisted knee surgery can help people recover better and feel more satisfied compared to traditional knee surgery.
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Exploring early radiation treatment for cancer patients before biopsy results
This study is testing if giving radiation treatment to cancer patients before their biopsy results can be done safely and help reduce wait times for urgent care.
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Rehabilitation program to reduce fatigue after COVID-19
This study is testing a new rehabilitation program called COVIDEx to see if it can help people with Long COVID feel less tired compared to standard care.
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Understanding the impact of wait times on hip and knee replacement patients
This study looks at how wait times for hip and knee replacements affect patients' health and recovery to help create better care plans for them.
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Using Adalimumab to treat early inflammatory arthritis caused by immune checkpoint inhibitors
This study is testing if adalimumab can help people with early inflammatory arthritis caused by cancer treatments to feel better and rely less on steroids.
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Sensory Motor Arousal Regulation Treatment (SMART) for PTSD
We will try a movement- and body-based therapy called SMART to help adults with PTSD.
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Assessing the impact of a new dialysis method on patient symptoms
This study is testing a new dialysis method to see if it can help people with end-stage kidney disease feel better by reducing their symptoms during treatment.
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Understanding risk factors in left ventricular non-compaction
This study looks at what factors might increase risks for people with left ventricular non-compaction and how these factors affect their heart health over time.
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Reducing respiratory symptoms in lung cancer patients with interstitial lung disease during radiation therapy
This study is testing if a combination of N-acetylcysteine and corticosteroids can help lung cancer patients with interstitial lung disease breathe easier during radiation therapy.
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Investigating genetic factors in patients with neurodegenerative dementia
This study is trying to find out if certain genetic factors are linked to neurodegenerative dementias like Alzheimer's and Lewy Body dementia by looking at blood samples from patients and their family members.
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Comparing PENG Block and Local Anesthetic Infiltration for Hip Surgery Pain Relief
This study is testing if a new pain relief method called the PENG block works as well as the usual local anesthetic for people having hip replacement surgery.
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Combining brain stimulation with steroid injections for chronic spinal pain relief
This study is testing whether combining brain stimulation with steroid injections can provide better and longer-lasting pain relief for people with chronic spinal pain.
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Personalized medicine for cancer treatment
This study is testing if personalized medicine recommendations can improve how well antidepressants, pain medications, and anti-nausea drugs work for cancer patients by looking at their genetic makeup and medication interactions.
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Examining the impact of synovectomy on pain relief after knee replacement surgery
This study is testing if removing inflamed tissue during knee replacement surgery can help people with osteoarthritis feel less pain and be happier with their results.
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Mobile app for recovery guidance in children with ankle sprains
This study is testing whether a smartphone app can help kids and young adults recover better from ankle sprains compared to just using a paper handout.
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Stereotactic Ablative Radiotherapy for Patients with Oligometastases and a Primary Tumor
This study is testing if adding a special type of targeted radiation therapy to standard treatment can help people with a primary tumor and a few metastases feel better and live longer.
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Investigating heart inflammation after a stroke
This study is trying to see if heart inflammation is linked to strokes by comparing heart health in stroke patients and those with other neurological symptoms.
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Finding early biological signs of severe illness in ICU patients
The study will collect blood, lung, and rectal samples from adults newly admitted to the ICU to see if early biological signs can help diagnose and personalize care for sepsis, ARDS, or other critical illnesses.
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Effects of cannabis on blood vessels
This study looks at how using cannabis affects blood vessels and inflammation in people who regularly use it compared to those who don’t.
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Ablative radiotherapy for metastatic cancer treatment
This study is testing if a new type of targeted radiation therapy can help people with multiple metastatic cancers live longer and feel better compared to standard treatment.
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Digital healthcare application for cardiac patients
This study tests a digital health app called VIRTUES to see if it can help people with heart conditions manage their health better, especially those living in rural areas without easy access to clinics.
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Reducing distress in children during laceration repair
This study is testing which of three medications can help reduce anxiety and distress in children aged 2 to 12 during stitches for cuts.
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Personalized home interventions to improve cognition in older adults with mild cognitive impairment
This study tests whether a personalized home program that includes exercise, brain training, diet tips, and sleep help can improve thinking skills in older adults with mild cognitive impairment.
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Using Gadoxetate MRI to improve detection of liver metastases in colorectal cancer
This study is testing if a special type of MRI can better identify liver tumors in patients with colorectal cancer to help guide their treatment.
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Monitoring brain activity during withdrawal of life support
This study is testing how brain activity changes when life support is stopped to help understand the timing of death and improve trust in organ donation.
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Using computer navigation to improve hip joint replacement surgery
This study is testing if using computer navigation during hip replacement surgery can help people with hip osteoarthritis get better results and fewer problems with their implants.
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Evaluating IM Epinephrine for Pediatric Cardiac Arrest
This study is testing if giving epinephrine through a shot in the muscle can help children who have a cardiac arrest outside of the hospital recover faster and have better outcomes compared to the usual methods.
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Comparing two surgical methods for treating ankle fractures in elderly patients
This study is testing which surgical method works better for treating ankle fractures in frail elderly patients: a fusion surgery or a method that uses plates and screws.
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Imaging kidney sodium levels using MRI
This study is testing if a special MRI can show differences in sodium levels in the kidneys of people with various kidney diseases to help improve their treatment.
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Extracorporeal Photopheresis for Early Diffuse Cutaneous Systemic Sclerosis
This study tests whether extracorporeal photopheresis can help people with early diffuse cutaneous systemic sclerosis see if it’s safe and might improve skin symptoms.
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Sampling chest lymph nodes in patients with advanced lung cancer before radiation treatment
This study is testing if checking lymph nodes in the chest with special needles helps doctors better understand lung cancer in patients before they receive targeted radiation treatment.
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Comparing standard and guided radiation therapy for liver cancer
This study is testing if a new way of guiding radiation therapy can help people with liver cancer get better results and less damage to healthy tissue compared to the standard method.
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Monitoring fluid intake and weight gain after hemodialysis
This study looks at how drinking fluids and gaining weight between dialysis sessions affects people who are on chronic hemodialysis.
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Shortened external beam radiotherapy for cervical cancer
This study tests if a shorter course of radiation therapy combined with chemotherapy can effectively treat patients with locally advanced cervical cancer while being easier for them to manage.
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Comparing Heparin and Placebo in Patients Undergoing Cardiac Catheterization
This study is testing whether different doses of heparin can help prevent complications like bruising and artery blockage in patients getting a heart procedure through their wrist.
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Retreating advanced lung cancer patients with osimertinib after chemotherapy
This study is testing if giving osimertinib again can help people with advanced lung cancer who didn't respond to earlier treatments feel better and live longer.
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Therapeutic treatment for PTSD using Deep Brain Reorienting
This study is testing a new treatment called Deep Brain Reorienting to see if it can help people with PTSD manage their symptoms better.
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Comparing radiotherapy and trans-oral surgery for HPV-negative oropharyngeal cancer
This study is testing whether radiotherapy or trans-oral surgery works better as the first treatment for early-stage HPV-negative throat cancer.
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Using intranasal dexmedetomidine and ketamine for sedation in children with fractures
This study is testing a new way to help kids aged 2-17 feel calm and comfortable during treatment for fractures by using a nasal spray instead of an IV.
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Evaluating advanced therapies for Rheumatoid Arthritis
This study is testing whether a new type of oral medication for rheumatoid arthritis works better than a common injection treatment over two years.
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An app to help manage recovery from concussion
This study is testing a new app that helps people recovering from a concussion manage their daily activities based on how they're feeling.
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Comparing TACE alone to TACE with SBRT for liver cancer treatment
This study is testing whether combining a common liver cancer treatment called TACE with a special type of radiation therapy called SBRT works better than TACE alone for patients with liver cancer that can’t be surgically removed.
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Comparing low-dose and high-dose cisplatin for head and neck cancer treatment
This study is testing whether giving lower doses of cisplatin can help people with advanced head and neck cancer avoid serious side effects, like hearing loss, while still getting effective treatment.
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Using gait to predict dementia and falls in older adults
This study is trying to see if changes in how older adults walk can help predict their risk of developing dementia and falling.
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Examining sodium buildup in tissues of kidney disease patients
This study is testing how sodium builds up in the skin, muscles, and bones of people with chronic kidney disease and those on dialysis to see how it relates to their symptoms and health markers.
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Imaging neuroinflammation in frontotemporal dementia
This study is testing a new imaging technique to see how inflammation in the brain affects people with frontotemporal dementia and how it varies among different types of the condition.
Quick answers
How many clinical trials run by London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's are recruiting right now?
77, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.
Where are these trials running?
In 2 countries. The most sites are in Canada (77 trials), Switzerland (2 trials). Each study page lists its sites and which ones are recruiting.
What phases are they in?
Phase 2: 8, Phase 3: 4, Phase 2/3: 2, Early Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.
How do I join one?
Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.
Find the studies that fit you
A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.