Comparing PENG Block and Local Anesthetic Infiltration for Hip Surgery Pain Relief
Official title: Ultrasound-guided Pericapsular Nerve Group (PENG) Block vs. Intraoperative Local Anesthetic Infiltration (ILAI) for Total Hip Arthroplasty (THA): a Single Center, Non-inferiority Randomized Control Trial Pilot Study.
Run by London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's · NCT05898581 · Data updated 2026-11-12
This study is testing if a new pain relief method called the PENG block works as well as the usual local anesthetic for people having hip replacement surgery.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 19 Years and up |
| Sex | All |
| Enrollment | 60 (estimated) |
| Sponsor | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's Academic / other |
| Locations | 1 site (London, Ontario) |
| Status | Recruiting |
| Started | November 1, 2024 |
| Main results expected | June 30, 2026 |
| Study ends | July 1, 2026 |
| Registry record updated | September 18, 2025 |
| Trial ID | NCT05898581 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are adults over 18 years old who are scheduled for total hip arthroplasty using a direct lateral surgical approach.
✕Probably not a fit
Patients who may not benefit from this study include those with contraindications for spinal anesthesia or regional analgesia, as well as those undergoing hip revision surgeries.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study investigates the effectiveness of the ultrasound-guided pericapsular nerve group (PENG) block compared to traditional intraoperative local anesthetic infiltration for managing postoperative pain in patients undergoing total hip arthroplasty (THA). The PENG block aims to provide effective pain relief while minimizing motor weakness, which is a common side effect of other nerve blocks. The study will include adult patients who are undergoing THA with a direct lateral surgical approach and will assess the analgesic outcomes and cost benefits associated with each method. The goal is to determine if the PENG block can offer non-inferior pain management compared to the standard infiltration technique.
Why it matters
Potential benefit: If successful, this approach could lead to improved pain management and faster recovery for patients undergoing total hip arthroplasty.
How similar studies have gone: While traditional nerve blocks have been widely studied, the PENG block is a newer technique with limited data, making this study a novel exploration in this area.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Adult patient (\>18 years old) 2. Undergoing THA with a direct lateral surgical approach (transgluteal approach) 3. Ability to provide verbal/written consent to participate in this trial Exclusion Criteria: 1. Patient with any contraindication for spinal anesthesia 2. Patient with any contraindication for regional analgesia 3. Patient undergoing THA with a direct anterior surgical approach 4. Patients undergoing THA for hip revision 5. Patients undergoing THA under One Day Stay (ODS) admission 6. Patients that received opioids intrathecally 7. Patients having residual motor block six hours after the completion of the spinal anesthesia. 8. Patients with a history of regular opioid intake for more than three months 9. Patients incapable of performing knee extension of the same operative side 10. Pregnant patients
Where it's running
-
London Health Sciences Centre
London, Ontario, Canada Recruiting
Study contacts
- Principal investigator: Shalini Dhir, FRCPC — Western University
- Study coordinator: Shalini Dhir, FRCPC
- Email: shalini.dhir@sjhc.london.on.ca
- Phone: 519-685-8500
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.