Evaluating IM Epinephrine for Pediatric Cardiac Arrest

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This trial evaluates the use of intramuscular (IM) epinephrine in children experiencing out-of-hospital cardiac arrest (POHCA) through a pragmatic, two-arm, open-label design. It aims to determine if IM administration can provide a quicker and safer initial dose of epinephrine compared to traditional intravenous or intraosseous methods. The study will assess the impact of IM epinephrine on the time to return of spontaneous circulation (ROSC) and overall patient outcomes. This is the first trial to investigate the use of IM epinephrine specifically in the context of pediatric cardiac arrest.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Children aged 1 day to and including 17 years experiencing an out-of-hospital cardiac arrest (OHCA)
* Must be receiving at least 1 minute of CPR by trained first responders (police, fire, or paramedic services)

Exclusion Criteria:

\- Children who experience OHCA due to an obvious traumatic event.

Where it's running

• Children's Hospital - London Health Sciences Centre
  London, Ontario, Canada Recruiting

Study contacts

• Principal investigator: Janice Tijssen, MD MSc — London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
• Study coordinator: Maysaa Assaf
• Email: maysaa.assaf@lhsc.on.ca
• Phone: 519-685-8500

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.